| Aβ(1-42) disrupts the expression and function of KLF2 in Alzheimer's disease mediated by p53. | |
| | |
MedLine Citation:
|
PMID: 23313511 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Blood brain barrier (BBB) dysfunction and impaired permeability are implicated in the pathological process of AD, but the underlying mechanisms are poorly understood. Kruppel-like factor 2 (KLF2) plays a critical role in regulating vascular functions, including vascular barrier permeability. The expression patterns and functions of KLF2 in AD progress are still unknown. In the current study, we investigated whether alterations in KLF2 contribute to cerebrovascular dysfunction in AD. Our results demonstrated that decreased expression level of KLF2 in the brains of Tg2576 transgenic mice was due to accumulation of Aβ. Importantly, overexpression of KLF2 could completely rescue impaired expression of tight junction protein Occludin induced by Aβ(1-42) in primary human brain endothelial cells (HBMECs). At last, p53 was verified to mediate Aβ(1-42) induced reduction of KLF2. Overall, this is the first time to report that KLF2 is involved in cerebrovascular dysfunction in Alzheimer's disease. |
| | |
Authors:
|
Chunyan Wu; Fengling Li; Guosheng Han; Zhihui Liu |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-10 |
Journal Detail:
|
Title: Biochemical and biophysical research communications Volume: - ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2013. Published by Elsevier Inc. |
Affiliation:
|
Department of Neurology, Affiliated Hospital of Weifang Medical University, No. 465 Yuhe Road Kuiwen, Weifang, Shandong, 261031, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hydrogen sulfide is produced by cystathionine ?-lyase at the steady-state low intracellular Ca(2+) c...
Next Document: Expression analysis of XPhyH-like during development and tail regeneration in Xenopus tadpoles: poss...