Document Detail

[99mTc]diphosphonate uptake and hemodynamics in arthritis of the immature dog knee.
MedLine Citation:
PMID:  1992069     Owner:  NLM     Status:  MEDLINE    
The relationship between [99mTc]diphosphonate uptake and bone hemodynamics was studied in canine carrageenan-induced juvenile chronic arthritis. Blood flow was determined with microspheres, plasma and red cell volumes were measured by labeled fibrinogen and red cells, and the microvascular volume and mean transit time of blood were calculated. Normal femoral epiphyses had lower central and higher subchondral blood flow and diphosphonate uptake values. Epiphyseal vascular volume was uniform, resulting in a greater transit time of blood centrally. In arthritis, blood flow and diphosphonate uptake were increased subchondrally and unaffected centrally, while epiphyseal vascular volume was increased throughout, leading to prolonged transit time centrally. The normal metaphyses had low blood flow and diphosphonate uptake values in cancellous bone and very high values in growth plates, but a large vascular volume throughout. The mean transit time therefore was low in growth plates and high in adjacent cancellous bone. Arthritis caused decreased blood flow and diphosphonate uptake in growth plates but increased vascular volume and transit time of blood. Diphosphonate uptake correlated positively with blood flow and plasma volume and negatively with red cell volume in a nonlinear fashion. Thus, changes in diphosphonate uptake and microvascular hemodynamics occur in both epiphyseal and metaphyseal bone in chronic synovitis of the immature knee. The [99mTc]diphosphonate bone scan seems to reflect blood flow, plasma volume, and red cell volume of bone.
E S Hansen; K Søballe; T B Henriksen; V E Hjortdal; C Bünger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of orthopaedic research : official publication of the Orthopaedic Research Society     Volume:  9     ISSN:  0736-0266     ISO Abbreviation:  J. Orthop. Res.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-03-14     Completed Date:  1991-03-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8404726     Medline TA:  J Orthop Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  191-202     Citation Subset:  IM    
Department of Orthopaedic Surgery, University of Aarhus, Denmark.
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MeSH Terms
Arthritis / physiopathology*
Diphosphonates / diagnostic use
Epiphyses / metabolism
Femur / blood supply,  metabolism,  physiopathology
Growth Plate / metabolism
Knee Joint / metabolism,  physiopathology*
Regional Blood Flow
Technetium / diagnostic use
Technetium Compounds*
Reg. No./Substance:
0/Diphosphonates; 0/Technetium Compounds; 52997-55-4/technetium Tc 99m diphosphonate; 7440-26-8/Technetium; 9000-07-1/Carrageenan

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