Document Detail

99mTc-white cell scanning to detect gut inflammation in children with inflammatory bowel diseases or spondyloarthropathies.
MedLine Citation:
PMID:  9631759     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Gut inflammation is a common feature shared by inflammatory bowel diseases (IBD) and the spondyloarthropathies (SpA). The aim of the present study was to compare the reliability of a number of non-invasive investigations for the detection of an inflammatory process of the intestine. METHODS: Forty-two children were studied: (i) patients with a previous diagnosis of IBD (group A); (ii) patients with suspected IBD (group B); and (iii) patients with predominantly rheumatological manifestations associated with gastrointestinal symptoms (group C). All the patients were studied using 99mTechnetium-HMPAO labelled white cell scanning (99mTc-WCS), and abdominal ultrasound (US). In addition the ESR, serum class A immunoglobulins, faecal occult blood (OB) and faecal alpha 1-antitripsin level (F alpha 1-AT) were determined. Colonoscopy plus multiple biopsies and radiological study of the intestine were used as gold standards. RESULTS: 99mTc-WCS showed the highest sensitivity (85%) and specificity (100%) in detecting the presence of gut inflammation. This was followed by ESR and faecal occult blood (63% sensitivity, 44% specificity), F alpha 1-AT (43% sensitivity, 44% specificity) and IgA (42% sensitivity, 88% specificity). Ultrasound was informative in 28% of the active/affected patients, with a specificity of 75%. CONCLUSION: Although ileo-pancolonscopy remains the gold standard for the histological characterisation of gut inflammation, 99mTc-WCS represents the most reliable non-invasive test for its detection.
A Barabino; M Gattorno; M Cabria; M P Sormani; M Occhi; G Villavecchia; P Gandullia; A Buoncompagni; E Castellano; P Picco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  16     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    1998 May-Jun
Date Detail:
Created Date:  1998-08-24     Completed Date:  1998-08-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  327-34     Citation Subset:  IM    
Pediatric Gastroenterology Unit, G. Gaslini Scientific Institute for Children, Genoa, Italy.
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MeSH Terms
Child, Preschool
Colitis, Ulcerative / complications,  immunology,  radionuclide imaging*
Crohn Disease / complications,  immunology,  radionuclide imaging*
Joint Diseases / complications,  immunology*
Predictive Value of Tests
Radionuclide Imaging / standards
Reproducibility of Results
Sensitivity and Specificity
Spinal Diseases / complications,  immunology*
Technetium Tc 99m Exametazime / diagnostic use
Reg. No./Substance:
100504-35-6/Technetium Tc 99m Exametazime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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