Document Detail

99mTc-sestamibi: its clinical role as a viability agent.
MedLine Citation:
PMID:  1486119     Owner:  NLM     Status:  MEDLINE    
The correlation between the presence of viable myocardium and 99mTc-sestamibi uptake is still to be defined. Preliminary studies indicate that: 1) reduced 99mTc-sestamibi uptake at rest is not necessarily evidence of scar tissue, and 2) its uptake is correlated to the severity of coronary stenosis. To define the relationship between rest thallium-201 and 99mTc-sestamibi uptake in dyssynergic segments, we studied 10 patients with ventricular dysfunction. 99mTc-sestamibi uptake was higher than thallium-201 uptake in normal segments but was similarly reduced in segments perfused by stenotic coronary arteries with or without wall motion abnormalities. Post-revascularization studies of regional wall motion showed that 99mTc-sestamibi had a positive and a negative predictive accuracy in identifying viable segments of 88 and 69%, respectively; these values were significantly lower than that provided by Thallium-201. 99mTc-sestamibi appears to be a primary perfusion agent with a high sensitivity to blood flow reduction at rest; it can be cautiously used as a viability agent in segments with wall motion abnormalities at rest.
P Marzullo; G Sambuceti
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear biology and medicine (Turin, Italy : 1991)     Volume:  36     ISSN:  0368-3249     ISO Abbreviation:  J Nucl Biol Med     Publication Date:    1992 Jul-Sep
Date Detail:
Created Date:  1993-02-24     Completed Date:  1993-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9110209     Medline TA:  J Nucl Biol Med     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  259-66     Citation Subset:  IM    
CNR Institute of Clinical Physiology, Pisa, Italy.
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MeSH Terms
Cell Survival
Coronary Disease / metabolism,  radionuclide imaging*
Exercise Test
Middle Aged
Myocardial Revascularization
Technetium Tc 99m Sestamibi / diagnostic use*,  pharmacokinetics
Thallium Radioisotopes / diagnostic use*,  pharmacokinetics
Tissue Distribution
Reg. No./Substance:
0/Thallium Radioisotopes; 109581-73-9/Technetium Tc 99m Sestamibi

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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