| 99mTc-labeling studies of a modified metronidazole and its biodistribution in tumor bearing animal models. | |
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MedLine Citation:
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PMID: 12623111 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A cysteine-based bifunctional chelating agent viz. N-(2'-hydroxybenzyl)-cysteine with a free carboxylic acid group (CAA) was synthesized. Bearing in mind the affinity of localization of nitroimidazoles in hypoxic tissues, this bifunctional chelating agent was coupled to metronidazole (MNZ). The (99m)Tc labeling studies of the novel agent (MNZCAA) thus obtained, was carried out and the radiolabeled product was subsequently purified. The complexation yield under optimized condition was approximately 85%. Biodistribution studies carried out in Swiss mice bearing 'barcl-95' tumors showed selective accumulation of the injected activity in the tumor (1.70%/g at 30 min p.i.) with renal as well as hepatobiliary clearance. High tumor/muscle ratio (14.7 at 3 h post-injection) of the novel agent indicates considerable promise towards further evaluation. |
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Authors:
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Tapas Das; Sharmila Banerjee; Grace Samuel; H D Sarma; Aruna Korde; Meera Venkatesh; M R A Pillai |
Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Nuclear medicine and biology Volume: 30 ISSN: 0969-8051 ISO Abbreviation: Nucl. Med. Biol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-03-07 Completed Date: 2003-10-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9304420 Medline TA: Nucl Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 127-34 Citation Subset: IM |
Affiliation:
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Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Isotope Labeling / methods Lymphoma / metabolism*, radionuclide imaging* Metabolic Clearance Rate Metronidazole / analogs & derivatives, diagnostic use*, pharmacokinetics* Mice Neoplasm Transplantation Organ Specificity Radiopharmaceuticals / chemical synthesis, diagnostic use, pharmacokinetics Technetium Compounds / diagnostic use*, pharmacokinetics* Thymus Neoplasms / metabolism, radionuclide imaging Tissue Distribution Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 0/Technetium Compounds; 443-48-1/Metronidazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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