| 99mTc-labeled field bean protease inhibitor can function as an efficient tumor detecting agent. | |
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MedLine Citation:
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PMID: 12018574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Purified field bean protease inhibitor (FBPI) was labeled with 99mTcO4- to ascertain its ability to locate tumors in tumor-bearing rat models. The labeling was done with Sn2+ as a reducing agent and the yield was 95%. It was stable for 2 hr at ambient temperature. The biodistribution study of the intravenously injected radiolabeled FBPI in normal Wistar rats at various time intervals showed a rapid blood clearance from the systemic circulation (approximately 5hr). The complex was predominantly excreted through the renal and the hepatobiliary systems. In vivo distribution and scintiimaging of 99mTc-FBPI were carried out in rats bearing carcinogen-induced mammary tumor or transplanted C6-gliomas. The results obtained were compared with conventional tumor-seeking radiopharmaceuticals such as 99mTc-(V)dimercaptosuccinic acid (DMSA), 201Thallous chloride (TICI) and 99mTc-Citrate. The tumor to muscle (T/M) ratios obtained with 99mTc-FBPI in rat C6 glioma was nearly 2 to 5-fold higher than obtained with all the three conventional tumor-seeking agents. The T/M ratio obtained with 99mTc-FBPI in rat mammary tumor on the other hand appeared to be 2-3-fold higher than noted with 99mTc(V)-DMSA and 201TlCl. The ratio was however comparable with that obtained with 99mTc-Citrate. The study indicated that 99mTc-FBPI has the specific potentials for imaging gliomas and possibly other tumors as well. |
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Authors:
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S Murugesan; A P Banerji; O P Noronha; A M Samuel; A O Fernandes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of experimental biology Volume: 39 ISSN: 0019-5189 ISO Abbreviation: Indian J. Exp. Biol. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2002-05-20 Completed Date: 2002-06-13 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0233411 Medline TA: Indian J Exp Biol Country: India |
Other Details:
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Languages: eng Pagination: 742-7 Citation Subset: IM |
Affiliation:
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Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Parel, Mumbai, India. smuru1999@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Neoplasms / radionuclide imaging* Fabaceae / chemistry* Female Glioma / radionuclide imaging* Male Mammary Neoplasms, Experimental / radionuclide imaging* Organotechnetium Compounds / diagnostic use*, pharmacokinetics Protease Inhibitors / diagnostic use*, pharmacokinetics Radiopharmaceuticals / diagnostic use*, pharmacokinetics Rats Rats, Wistar Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Organotechnetium Compounds; 0/Protease Inhibitors; 0/Radiopharmaceuticals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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