Document Detail

99mTc-hydroxymethane diphosphonate: a new bone imaging agent with a low tin content.
MedLine Citation:
PMID:  6446106     Owner:  NLM     Status:  MEDLINE    
A prospective double-blind comparison of 99mTc-hydroxymethane diphosphonate (HMDP) and 99mTc-methylene diphosphonate (MDP) as bone-seeking agents was performed with 102 patients. Densitometry showed that both cancellous/compact bone and cancellous bone/soft-tissue ratios were greater with HMDP (p less than 0.05); compact bone/soft-tissue and bone lesion/normal bone ratios were the same with both agents. Bone delineation, soft-tissue uptake, and overall image quality were the same with both agents. The HMDP formulation contained 78% fewer stannous ions and had a longer useful life after technetium labeling than MDP.
P A Domstad; J J Coupal; E E Kim; J S Blake; F H DeLand
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Radiology     Volume:  136     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-08-15     Completed Date:  1980-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  209-11     Citation Subset:  AIM; IM    
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MeSH Terms
Bone Neoplasms / radionuclide imaging
Bone and Bones / radionuclide imaging*
Child, Preschool
Diphosphonates / analysis,  diagnostic use*
Double-Blind Method
Middle Aged
Technetium / analysis,  diagnostic use*
Technetium Tc 99m Medronate
Tin / analysis*
Reg. No./Substance:
0/Diphosphonates; 63347-66-0/Technetium Tc 99m Medronate; 72945-61-0/technetium Tc 99m hydroxymethylene diphosphonate; 7440-26-8/Technetium; 7440-31-5/Tin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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