Document Detail


99mTc-human immunoglobulin (HIG) in AIDS patients: first results.
MedLine Citation:
PMID:  1932171     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Scintigraphy with 99mTc labelled human polyclonal immunoglobulin was performed in 16 patients with ascertained or suspected AIDS-related infections. 99mTc-HIG lung scanning was compared, in 11 patients, with 67Ga scintigraphy, chest X-ray and high resolution lung CT. 67Ga and 99mTc-HIG were concordantly positive in five cases of BAL-ascertained Pneumocystis carinii pneumonia (PCP), while one of them was Rx and CT negative. X-ray, 67Ga and 99mTc were concordantly negative in 5 cases. 99mTc-HIG yielded negative results in two cases of Mycobacterium infection, both of which were 67Ga and Rx positive: Mycobacterium avium in diffuse lung involvement and Mycobacterium TBC in excavated infiltrate. 99mTc-HIG was also positive in other 3 AIDS patients: 1 case of intestinal cryptosporidiosis, 1 pulmonary abscess (Staphylococcus and Candida), and 1 sacral abscess; it was negative in 1 case of Kaposi sarcoma (also 201Tl negative). In conclusion, 99mTc-HIG scintigraphy in AIDS patients is feasible, and offers some practical advantages (continuous availability, fast response time, etc.). The initial results seem similar to those of 67Ga in lung scanning (and perhaps more specific for PCP).
Authors:
G Galli; M Salvatori; M Antoni; L Ortona; G Ventura; G Maiuro; T Pirronti; P Marano
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear biology and medicine (Turin, Italy : 1991)     Volume:  35     ISSN:  0368-3249     ISO Abbreviation:  J Nucl Biol Med     Publication Date:    1991 Jan-Mar
Date Detail:
Created Date:  1991-12-12     Completed Date:  1991-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9110209     Medline TA:  J Nucl Biol Med     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  14-20     Citation Subset:  IM; X    
Affiliation:
Institute of Nuclear Medicine, Catholic University of the Sacred Heart, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / complications,  microbiology
Adult
Citrates / diagnostic use
Citric Acid
Female
Humans
Immunoglobulins / diagnostic use*
Male
Mycobacterium avium-intracellulare Infection / radionuclide imaging*
Pneumonia, Pneumocystis / radionuclide imaging*
Technetium / diagnostic use*
Chemical
Reg. No./Substance:
0/Citrates; 0/Immunoglobulins; 0/technetium Tc 99m immunoglobulin; 7440-26-8/Technetium; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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