Document Detail

(99m)Tc-TRODAT-1 and (123)I-IBZM SPECT studies in a patient with extrapontine myelinolysis with parkinsonian features.
MedLine Citation:
PMID:  19381760     Owner:  NLM     Status:  MEDLINE    
Osmotic demyelination syndrome can result from the rapid correction of hyponatremia, and is categorized by central pontine myelinolysis and extrapontine myelinolysis (EPM). Magnetic resonance imaging (MRI) is currently the most useful modality for visualizing EPM lesions. However, MRI is unable to delineate the severity of involvement in the nigrostriatal dopaminergic pathway. The authors describe the case of a 48-year-old woman who developed isolated EPM with predominantly right-sided parkinsonian symptoms after rapid correction of hyponatremia. MRI revealed symmetrical demyelinating lesions in the bilateral striatum without central pontine involvement. (99m)Tc-TRODAT-1 and (123)I-iodobenzamide ((123)I-IBZM) single-photon emission computed tomography (SPECT) images showed unequally decreased uptake in the bilateral striatum. Treatment with carbidopa/levodopa improved the clinical parkinsonian symptoms. (99m)T(C)-TRODAT-1 and (123)I-IBZM SPECT images provide presynaptic and postsynaptic molecular information of the nigrostriatal dopaminergic pathway. The lesions demonstrated in the (99m)T(C)-TRODAT-1 and (123)I-IBZM SPECT images show higher correlation with the severity of clinical features in EPM than MRI, and the modalities may be useful in the evaluation of patients with parkinsonian symptoms.
Yi-Chung Wu; Giia-Sheun Peng; Chun-An Cheng; Chun-Chieh Lin; Wen-Sheng Huang; Chun-Jen Hsueh; Jiunn-Tay Lee
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-04-21
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  23     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-12     Completed Date:  2009-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  409-12     Citation Subset:  IM    
Department of Internal Medicine, Hualien Armed Forces General Hospital, Hualien, Taiwan, ROC.
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MeSH Terms
Benzamides / diagnostic use*,  metabolism
Dopamine / metabolism
Hyponatremia / complications,  metabolism
Middle Aged
Myelinolysis, Central Pontine / complications*,  metabolism,  pathology,  radionuclide imaging*
Organotechnetium Compounds / diagnostic use*,  metabolism
Parkinsonian Disorders / complications*,  metabolism,  pathology,  radionuclide imaging*
Pyrrolidines / diagnostic use*,  metabolism
Substantia Nigra / metabolism
Tomography, Emission-Computed, Single-Photon
Tropanes / diagnostic use*,  metabolism
Reg. No./Substance:
0/Benzamides; 0/Organotechnetium Compounds; 0/Pyrrolidines; 0/Tropanes; 0/technetium Tc 99m TRODAT-1; 84226-06-2/3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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