Document Detail

99mTc-HMPAO labelled white blood cell scintigraphy in the diagnosis and monitoring of response of the therapy in patients with active bronchiectasis.
MedLine Citation:
PMID:  21550146     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of this study was to assess the role of labelled leukocyte scintigraphy in the diagnosis and monitorization of response to therapy of patients with active bronchiectasis.
MATERIAL AND METHODS: Twenty patients underwent (99m)Technetium hexamethylpropyleneamine oxime ((99m)Tc-HMPAO) labelled white blood cell (WBC) scintigraphy. A second scintigraphy was performed in 13 patients at 10 day of the treatment. Regional (99m)Tc-HMPAO WBC uptake and radiologic imaging findings (high resolution computed tomography or Chest X-Ray) in the lungs were classified into 3 categories in 6 lung areas. scintigraphic, radiological and clinical disease scores were calculated for all patients.
RESULTS: An abnormal accumulation was visually observed in 19 of 20 patients on the pre-treatment scans, the scintigraphy showing 95% sensitivity. A significant difference was found between early and late ratios (P=0.001) in the pre-treatment scans. The infected areas revealed a significant decrease in uptake ratios on the post-treatment scans compared to the pre-treatment scans (P=0.001). However, no significant correlation was determined between clinical and radiological scores, clinical and scintigraphic scores and also between scintigraphic and radiological scores (P ≥ 0.05).
CONCLUSIONS: (99m)Tc-HMPAO WBC scintigraphy may be a useful tool to evaluate response to therapy in patients with active bronchiectasis.
G Altiay; T F Cermik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-06
Journal Detail:
Title:  Revista española de medicina nuclear e imagen molecular     Volume:  31     ISSN:  2253-8070     ISO Abbreviation:  Rev Esp Med Nucl Imagen Mol     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2012-01-30     Completed Date:  2012-09-25     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  101585329     Medline TA:  Rev Esp Med Nucl Imagen Mol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  9-14     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier España, S.L. and SEMNIM. All rights reserved.
Department of Chest Disease, Trakya University Hospital, Edirne, Turkey.
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MeSH Terms
Bronchiectasis / drug therapy,  radionuclide imaging*
Leukocytes / radionuclide imaging*
Middle Aged
Predictive Value of Tests
Prospective Studies
Radiopharmaceuticals / diagnostic use*
Technetium Tc 99m Exametazime / diagnostic use*
Reg. No./Substance:
0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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