Document Detail


99mTc-HMPAO brain perfusion single-photon emission computed tomography in children with Down syndrome: relationship to epilepsy, thyroid functions, and congenital heart disease.
MedLine Citation:
PMID:  16970855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In recent years, it has been possible for patients with Down syndrome to live longer with advanced medical treatment and social support. As a result, the problems of these patients, such as thyroid diseases, leukemia, and Alzheimer disease, would be encountered more frequently. In this study, we aimed to perform the brain perfusion of children with Down syndrome by technetium 99m hexamethylpropylene amine oxime (99mTc-HMPAO) single-photon emission computed tomography (SPECT) and to determine the relationship between brain perfusion and epilepsy, thyroid function tests, congenital heart disease, and level of mental and motor development. Thirty patients with Down syndrome, aged between 1 and 15 years, were included in our study. Demographic data, the existence of epilepsy and congenital heart defects, the level of mental and motor development, serum levels of thyroid hormones, and autoantibodies were determined. All patients underwent computed tomography (CT) and/or magnetic resonance imaging (MRI). Cerebral SPECT was performed in all cases to evaluate the brain perfusion pattern. According to the visual evaluation of cerebral SPECT results, hypoperfusion was detected in 11 cases (37%). Patients with cerebral hypoperfusion (group 1) and patients with normal cerebral perfusion (group 2) were compared. There was no difference between group 1 and group 2 in terms of demographic data, congenital heart defects, IQ levels, thyroid hormones, and autoantibodies, but the incidence of epilepsy was significantly higher in group 1 (P<.001). When motor and mental development levels were compared, it was found that cases in group 1 were significantly more retarded in personal-social and fine motor skills (P<.05). The present study showed that cerebral hypoperfusion in children with Down syndrome is mostly related to epilepsy and the other coexisting conditions, congenital heart disease and hypothyroidism. Patients with cerebral hypoperfusion also have more retarded developmental levels, especially in personal-social and fine motor skills.
Authors:
Suriye Altiay; Meryem Kaya; Serap Karasalihoglu; Aziz Gultekin; Naci Oner; Betul Biner
Related Documents :
8390935 - Determination of the autonomously functioning volume of the thyroid.
19139595 - Preoperative administration of excess iodide increases thyroid volume of patients with ...
3404495 - Thyroid disease and mental illness: a study of thyroid disease in psychiatric admissions.
8071455 - Diagnostic usefulness of thyroid ultrasonography in atrophic thyroiditis.
3160685 - Use of ipratropium aerosol in the long-term management of asthma.
21606455 - Diabetes mellitus and ischemic stroke in the young: clinical features and long-term pro...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of child neurology     Volume:  21     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-09-14     Completed Date:  2006-11-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  610-4     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Trakya University Medical Faculty, Edirne Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Cerebrovascular Circulation / physiology*
Child
Child Development*
Child, Preschool
Down Syndrome / complications,  physiopathology*,  radionuclide imaging
Epilepsy / complications,  physiopathology*
Female
Heart Defects, Congenital / complications,  physiopathology*
Humans
Hypothyroidism / complications,  physiopathology*
Infant
Intelligence
Male
Motor Skills
Radiopharmaceuticals / diagnostic use
Technetium Tc 99m Exametazime / diagnostic use
Tomography, Emission-Computed, Single-Photon
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  False-positive metaiodobenzylguanidine scan for neuroblastoma in a child with opsoclonus-myoclonus s...
Next Document:  Neuroradiologic findings in Sotos syndrome.