| 99mTc-DPD scintigraphy in transthyretin-related familial amyloidotic polyneuropathy. | |
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MedLine Citation:
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PMID: 12002714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Familial amyloidotic polyneuropathy (FAP) caused by amyloidogenic transthyretin (ATTR) mutations is the most common form of hereditary amyloidosis. We investigated the diagnostic value of the bone scanning agent technetium-99m 3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD) in this disease. Eight patients (four males, four females; age 54.4+/-8.3 years, range 43-67 years) with ATTR-FAP proven by immunohistochemistry and molecular analysis and a control group comprising ten oncological out-patients (five males, five females; age 53.4+/-8.5 years, range 34-66 years) without evidence of bony metastases were studied using 99mTc-DPD. Whole body tracer retention was 80.1%+/-10.3% (range 65.1%-94.8%) in FAP patients and 55.7%+/-8.1% (range 40.2%-66.7%) in controls at 3 h p.i. (P<0.001), and cardiac uptake was 7.3%+/-2.2% (range 4.2%-10.1%) in FAP patients and 3.1%+/-0.5% (range 2.3%-4.0%) in controls (P<0.001). The heart/whole body uptake ratio was 8.9%+/-1.7% (range 6.5%-11.0%) in FAP patients and 5.6%+/-0.5% (range 5.1%-6.8%) in controls (P<0.001). The three FAP patients with the highest cardiac tracer uptake had cardiomyopathy or arrhythmia. 99mTc-DPD scintigraphy is proposed as a simple and valuable diagnostic aid to evaluate the severity of the disease and the risk of concomitant heart problems. |
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Authors:
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Max Puille; Klaus Altland; Reinhold P Linke; Mary K Steen-Müller; Rigobert Kiett; Dagmar Steiner; Richard Bauer |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 29 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-05-10 Completed Date: 2002-11-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 376-9 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Justus-Liebig-University, Giessen, Germany. Max.F.Puille@radiol.med.uni-giessen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amyloid Neuropathies, Familial / metabolism, pathology, radionuclide imaging* Biopsy Diphosphonates / diagnostic use*, pharmacokinetics Female Heart / radionuclide imaging* Humans Male Middle Aged Organotechnetium Compounds / diagnostic use*, pharmacokinetics Radiopharmaceuticals / diagnostic use, pharmacokinetics Whole-Body Counting |
| Chemical | |
Reg. No./Substance:
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0/Diphosphonates; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acid |
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