Document Detail


99mTc-Anti-TNF-α Scintigraphy: A New Perspective Within Different Methods in the Diagnostic Approach of Active Graves Ophthalmopathy.
MedLine Citation:
PMID:  23047757     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
ABSTRACT: Different imaging methods applied in the evaluation of a patient with unilateral active Graves ophthalmopathy (GO) are shown in the present paper. Tc-anti-TNF-α scintigraphy is proposed as a promising method, not yet described, for the diagnosis of active ocular disease. It consists of labeling a human monoclonal antibody directed against TNF-α molecule (adalimumab) with technetium (Tc). The method is based on the demonstration of TNF-α as one of the cytokines enrolled in the initial active phase of GO development. The method may give the perspective to link diagnosis and therapy, including new target-based modalities.
Authors:
Flávia Paiva Proença Lobo Lopes; Sergio Augusto Lopes de Souza; Patrícia de Fátima Dos Santos Teixeira; Elisa Dos Santos Rebelo Pinho; Lea Mirian Barbosa da Fonseca; Mario Vaisman; Bianca Gutfilen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  37     ISSN:  1536-0229     ISO Abbreviation:  Clin Nucl Med     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1097-101     Citation Subset:  IM    
Affiliation:
From the *Departamento de Radiologia, Faculdade de Medicina, Universidade Federal do Rio de Janeiro; †Seção de Medicina Nuclear, Instituto Nacional de Câncer; ‡Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro; and §Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
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