| 99mTc-Anti-TNF-α Scintigraphy: A New Perspective Within Different Methods in the Diagnostic Approach of Active Graves Ophthalmopathy. | |
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MedLine Citation:
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PMID: 23047757 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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ABSTRACT: Different imaging methods applied in the evaluation of a patient with unilateral active Graves ophthalmopathy (GO) are shown in the present paper. Tc-anti-TNF-α scintigraphy is proposed as a promising method, not yet described, for the diagnosis of active ocular disease. It consists of labeling a human monoclonal antibody directed against TNF-α molecule (adalimumab) with technetium (Tc). The method is based on the demonstration of TNF-α as one of the cytokines enrolled in the initial active phase of GO development. The method may give the perspective to link diagnosis and therapy, including new target-based modalities. |
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Authors:
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Flávia Paiva Proença Lobo Lopes; Sergio Augusto Lopes de Souza; Patrícia de Fátima Dos Santos Teixeira; Elisa Dos Santos Rebelo Pinho; Lea Mirian Barbosa da Fonseca; Mario Vaisman; Bianca Gutfilen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 37 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1097-101 Citation Subset: IM |
Affiliation:
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From the *Departamento de Radiologia, Faculdade de Medicina, Universidade Federal do Rio de Janeiro; †Seção de Medicina Nuclear, Instituto Nacional de Câncer; ‡Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro; and §Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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