Document Detail


99m Tc-albumin nanocolloid joint scintigraphy in rheumatoid arthritis patients who are in clinical remission - is remission real ?
MedLine Citation:
PMID:  20426913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To make a comparison between the clinical data and the imaging results with 99mTc-nanocolloid scintigraphy in rheumatoid arthritis (RA) patients considered to be in remission. METHODS: Forty RA patients found to be in clinical remission according to the ACR and the EULAR (DAS28<2.6) criteria were studied. The group included 29 females and 11 males with a mean age of 60.8+/-13.5 years (range 22-86) and a mean disease duration of 13.4+/-7.7 years (range 2-23). The mean time of remission in the study group was 22.2+/-5.2 months (range 11-36). Each patient was given an intravenous injection of 555MBq of 99mTc-nanocalloid (NC). Spot views of the skeleton were taken and a SPECT-CT was done on the wrists and hands. A scan was considered positive when at least one of the hand joints showed increased tracer uptake. RESULTS: The 99mTc-nanocalloid scintigraphy was negative in 14 (35%) and positive for active joint disease in 26 (65%) patients. Twenty four out of the 26 patients with positive scan (92%) were sero-positive while those who had a negative scintigraphy were all sero-negative except one. No correlation was found between the type of treatment used, the time that elapsed from remission, or laboratory parameters (ESR CRP) and the scintigraphic results. CONCLUSIONS: The clinical criteria used for remission in RA are not consistent with the actual inflammatory activity in the joints. These results are especially emphasised in the subgroup of sero-positive patients.
Authors:
Moshe Tishler; Oleg Lysyy; Ofer Levy; Olga Volkov; Haim Golan
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-06-23
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  28     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-06-25     Completed Date:  2010-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  360-4     Citation Subset:  IM    
Affiliation:
Department of Medicine B, Assaf Harofe Medical Center, Zrifin, Israel. tishlerm@netvision.net.il
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Arthritis, Rheumatoid / radionuclide imaging*,  therapy*
Cohort Studies
Female
Hand / radionuclide imaging
Humans
Male
Middle Aged
Remission Induction
Technetium Tc 99m Aggregated Albumin / diagnostic use*,  pharmacokinetics
Tomography, Emission-Computed, Single-Photon / methods*
Wrist Joint / radionuclide imaging
Young Adult
Chemical
Reg. No./Substance:
0/Technetium Tc 99m Aggregated Albumin; 0/technetium Tc 99m nanocolloid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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