| A 90-day toxicology study of transgenic lysine-rich maize grain (Y642) in Sprague-Dawley rats. | |
| | |
MedLine Citation:
|
PMID: 19073230 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The gene for a lysine-rich protein (sb401) obtained from potatoes (Solanum berthaultii) was inserted into maize seed to produce Y642 transgenic maize. Compositional analysis of Y642 grain demonstrated that the concentrations of lysine and total protein were higher than those observed in maize grain from a near-isogenic non-genetically modified (non-GM) commercially available control quality protein maize (Nongda 108). The safety of Y642 maize grain was assessed by comparison of toxicology response variables in Sprague-Dawley (SD) rats consuming diets containing Y642 maize grain with those containing Nongda 108 maize grain. Maize grains from Y642 or Nongda 108 were incorporated into rodent diets at low (30%) or high concentrations (76%) and administered to SD rats (n=10/sex/group) for 90 days. An additional group of negative control group of rats (n=10/sex/group) were fed AIN93G diets. No adverse diet-related differences in body weights, feed consumption/utilization, clinical chemistry, hematology, absolute and relative organ weights were observed. Further, no differences in gross or microscopic pathology were observed between rats consuming diets with Y642 maize grain compared with rats consuming diets containing Nongda 108 maize grain. These results demonstrated that Y642 lysine-rich maize is as safe and nutritious as conventional quality protein maize. |
| | |
Authors:
|
Xiao Yun He; Mao Zhi Tang; Yun Bo Luo; Xin Li; Si Shuo Cao; Jing Juan Yu; Bryan Delaney; Kun Lun Huang |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-06 |
Journal Detail:
|
Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 47 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2009 Feb |
Date Detail:
|
Created Date: 2009-01-22 Completed Date: 2009-02-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
|
Languages: eng Pagination: 425-32 Citation Subset: IM |
Affiliation:
|
College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Tsinghua Donglu, Beijing 100083, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Weight / drug effects Clinical Chemistry Tests Eating / drug effects Female Hematologic Tests Longevity / drug effects Lysine / genetics, metabolism, toxicity* Male Organ Size / drug effects Plants, Genetically Modified / genetics, metabolism, toxicity* Rats Rats, Sprague-Dawley Toxicity Tests Vegetable Proteins / genetics, metabolism, toxicity* Zea mays / genetics, metabolism, toxicity* |
| Chemical | |
Reg. No./Substance:
|
0/Vegetable Proteins; 56-87-1/Lysine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Deficient mannose-binding lectin-mediated complement activation despite mannose-binding lectin-suffi...
Next Document: Effects of Urtica dioica L. seed on lipid peroxidation, antioxidants and liver pathology in aflatoxi...