Document Detail


A 90-day safety study of genetically modified rice expressing rhIGF-1 protein in C57BL/6J rats.
MedLine Citation:
PMID:  21910016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genetically modified plants expressing disease resistance traits offer new treatment strategies for human diseases, but at the same time present a challenge in terms of food safety assessment. The present 90-day feeding study was designed to assess the safety of transgenic rice expressing the recombinant human insulin-like growth factor-1 (rhIGF-1) compared to its parental wild rice. Male and female C57BL/6J rats were given a nutritionally balanced purified diet with 20% transgenic rhIGF-1 rice or 20% parental rice for 90 days. This corresponds to a mean daily rhIGF-1 protein intake of approximately 217.6 mg/kg body weight based on the average feed consumption. In the animal study a range of biological, biochemical, clinical, microbiological and pathological parameters were examined and several significant differences were observed between groups, but none of the effects were considered to be adverse. In conclusion, no adverse or toxic effects on C57BL/6J rats were observed in the design used in this 90-day study. These results will provide valuable information for the safety assessment of genetically modified food crops.
Authors:
Maoxue Tang; Tingting Xie; Wenke Cheng; Lili Qian; Shulin Yang; Daichang Yang; Wentao Cui; Kui Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-11
Journal Detail:
Title:  Transgenic research     Volume:  21     ISSN:  1573-9368     ISO Abbreviation:  Transgenic Res.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-09     Completed Date:  2012-09-06     Revised Date:  2012-09-10    
Medline Journal Info:
Nlm Unique ID:  9209120     Medline TA:  Transgenic Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  499-510     Citation Subset:  IM    
Affiliation:
State Key Laboratory for Animal Nutrition and Beijing Inspection Test Center for Biosafety of Genetically Modified Animal and Feed of the Ministry of Agriculture of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Load
Blood Chemical Analysis
Blood Glucose / metabolism
Body Weight
Feces / microbiology
Female
Food Safety / methods*
Food, Genetically Modified / toxicity*
Humans
Insulin-Like Growth Factor I / genetics,  metabolism*
Male
Mice
Mice, Inbred C57BL
Oryza sativa / genetics,  toxicity*
Plants, Genetically Modified / genetics,  metabolism*,  toxicity*
Quality Control
Recombinant Proteins / genetics,  metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Recombinant Proteins; 67763-96-6/Insulin-Like Growth Factor I
Comments/Corrections
Erratum In:
Transgenic Res. 2012 Aug;21(4):927

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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