| Is 9-cis-retinoic acid the endogenous ligand for the retinoic acid-X receptor? | |
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MedLine Citation:
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PMID: 17274495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Specific proteins in the nucleus act as transcription factors upon activation through binding of small molecules (all-trans-retinoic acid, thyroid hormone, vitamin D, and others). The activated (liganded) receptors bind to specific DNA elements as heterodimers, each in combination with the retinoic acid-X receptor (RXR). 9-Cis-retinoic acid binds to RXR with high affinity and activates it. Though 9-cis-retinoic acid was initially found in animal tissues, in later work 9-cis-retinoic acid could not be detected. A search for a ligand for RXR in tissues showed that unsaturated fatty acids, particularly linoleic, linolenic, and docosahexaenoic acids, bound to and activated RXR as specific ligands, although with low affinity. A critical experiment demonstrated that, at least in developing mouse skin, 9-cis-retinoic acid is not the ligand for RXR. |
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Authors:
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George Wolf |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Nutrition reviews Volume: 64 ISSN: 0029-6643 ISO Abbreviation: Nutr. Rev. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2007-02-05 Completed Date: 2007-02-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376405 Medline TA: Nutr Rev Country: United States |
Other Details:
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Languages: eng Pagination: 532-8 Citation Subset: IM |
Affiliation:
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Department of Nutritional Sciences and Toxicology, University of California, Berkeley, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fatty Acids, Unsaturated / metabolism* Humans Isomerism Ligands Receptors, Retinoic Acid / metabolism* Retinoid X Receptors / metabolism* Transcription Factors Tretinoin / chemistry, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated; 0/Ligands; 0/Receptors, Retinoic Acid; 0/Retinoid X Receptors; 0/Transcription Factors; 302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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