Document Detail

Is 9-cis-retinoic acid the endogenous ligand for the retinoic acid-X receptor?
MedLine Citation:
PMID:  17274495     Owner:  NLM     Status:  MEDLINE    
Specific proteins in the nucleus act as transcription factors upon activation through binding of small molecules (all-trans-retinoic acid, thyroid hormone, vitamin D, and others). The activated (liganded) receptors bind to specific DNA elements as heterodimers, each in combination with the retinoic acid-X receptor (RXR). 9-Cis-retinoic acid binds to RXR with high affinity and activates it. Though 9-cis-retinoic acid was initially found in animal tissues, in later work 9-cis-retinoic acid could not be detected. A search for a ligand for RXR in tissues showed that unsaturated fatty acids, particularly linoleic, linolenic, and docosahexaenoic acids, bound to and activated RXR as specific ligands, although with low affinity. A critical experiment demonstrated that, at least in developing mouse skin, 9-cis-retinoic acid is not the ligand for RXR.
George Wolf
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  64     ISSN:  0029-6643     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-02-05     Completed Date:  2007-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  532-8     Citation Subset:  IM    
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, USA.
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MeSH Terms
Fatty Acids, Unsaturated / metabolism*
Receptors, Retinoic Acid / metabolism*
Retinoid X Receptors / metabolism*
Transcription Factors
Tretinoin / chemistry,  metabolism*
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Ligands; 0/Receptors, Retinoic Acid; 0/Retinoid X Receptors; 0/Transcription Factors; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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