Document Detail


The MSH/ACTH(4-9) analog Org2766 counteracts isolation-induced enhanced social behavior via the amygdala.
MedLine Citation:
PMID:  1326104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MSH/ACTH-like peptides influence social behavior induced by isolation It has been previously demonstrated that changes in locomotor activity as a result of isolation can be counteracted by Org2766 via the amygdala. The present study investigates whether isolation-induced changes in social behavior can also be affected by this peptide via the amygdala. A fully automated observation system was applied for detailed registration and analysis of movements of group-housed and 7-day isolated rats in a social interaction test. Administration of the MSH/ACTH(4-9) analog into the central nucleus of the amygdala elicited decreased locomotion, approach, and avoidance behaviors after isolation as compared to placebo-treated controls. However, general activity and social interest of group-housed rats were not affected by the MSH/ACTH(4-9) fragment. It is hypothesized that the amygdala is a site of action for neuropeptides in modulating social behavior.
Authors:
T Hol; B M Spruijt
Related Documents :
21175924 - Decision-making deficits linked to real-life social dysfunction in crack cocaine-depend...
24707844 - Attitude-behavior consistency, the principle of compatibility, and organ donation: a cl...
15531644 - Heat in evolution's kitchen: evolutionary perspectives on the functions and origin of t...
23683554 - Attitudes of young adults from the uk towards organ donation and transplantation.
12028864 - A review of studies of sexual behaviour of school students in sub-saharan africa.
15362774 - Serum c3 complement concentrations correlate with liver function in patients with liver...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  13     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1992 May-Jun
Date Detail:
Created Date:  1992-10-14     Completed Date:  1992-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  541-4     Citation Subset:  IM; S    
Affiliation:
Division of Molecular Neurobiology, Rudolf Magnus Institute, University of Utrecht, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / analogs & derivatives*,  pharmacology
Amygdala / physiology*
Animals
Behavior, Animal / drug effects*
Male
Motor Activity / drug effects*
Peptide Fragments / pharmacology*
Social Isolation*
Chemical
Reg. No./Substance:
0/Peptide Fragments; 50913-82-1/Org 2766; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Molecular characterization of angiotensin II type II receptors in rat pheochromocytoma cells.
Next Document:  Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of th...