Document Detail

The MSH/ACTH(4-9) analog Org2766 counteracts isolation-induced enhanced social behavior via the amygdala.
MedLine Citation:
PMID:  1326104     Owner:  NLM     Status:  MEDLINE    
MSH/ACTH-like peptides influence social behavior induced by isolation It has been previously demonstrated that changes in locomotor activity as a result of isolation can be counteracted by Org2766 via the amygdala. The present study investigates whether isolation-induced changes in social behavior can also be affected by this peptide via the amygdala. A fully automated observation system was applied for detailed registration and analysis of movements of group-housed and 7-day isolated rats in a social interaction test. Administration of the MSH/ACTH(4-9) analog into the central nucleus of the amygdala elicited decreased locomotion, approach, and avoidance behaviors after isolation as compared to placebo-treated controls. However, general activity and social interest of group-housed rats were not affected by the MSH/ACTH(4-9) fragment. It is hypothesized that the amygdala is a site of action for neuropeptides in modulating social behavior.
T Hol; B M Spruijt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  13     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1992 May-Jun
Date Detail:
Created Date:  1992-10-14     Completed Date:  1992-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  541-4     Citation Subset:  IM; S    
Division of Molecular Neurobiology, Rudolf Magnus Institute, University of Utrecht, The Netherlands.
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MeSH Terms
Adrenocorticotropic Hormone / analogs & derivatives*,  pharmacology
Amygdala / physiology*
Behavior, Animal / drug effects*
Motor Activity / drug effects*
Peptide Fragments / pharmacology*
Social Isolation*
Reg. No./Substance:
0/Peptide Fragments; 50913-82-1/Org 2766; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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