Document Detail


9. Food allergy.
MedLine Citation:
PMID:  16455349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Food allergy, defined as an adverse immune response to food proteins, affects as many as 6% of young children and 3% to 4% of adults. Food-induced allergic reactions are responsible for a variety of symptoms involving the skin, gastrointestinal tract, and respiratory tract and might be caused by IgE-mediated and non-IgE-mediated (cellular) mechanisms. Our understanding of how food allergy represents an abrogation of normal oral tolerance is evolving. Although any food can provoke a reaction, relatively few foods are responsible for the vast majority of significant food-induced allergic reactions: milk, egg, peanuts, tree nuts, fish, and shellfish. A systematic approach to diagnosis includes a careful history, followed by laboratory studies, elimination diets, and often food challenges to confirm a diagnosis. Many food allergens have been characterized at a molecular level, which has increased our understanding of the immunopathogenesis of food allergy and might soon lead to novel diagnostic and therapeutic approaches. Currently, management of food allergies consists of educating the patient to avoid ingesting the responsible allergen and to initiate therapy in case of an unintended ingestion.
Authors:
Scott H Sicherer; Hugh A Sampson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  117     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-03     Completed Date:  2006-03-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S470-5     Citation Subset:  AIM; IM    
Affiliation:
The Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA. scott.sicherer@mssm.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Allergens / adverse effects
Anaphylaxis / etiology,  therapy
Anti-Asthmatic Agents / therapeutic use
Child
Child, Preschool
Diagnosis, Differential
Dietary Proteins / adverse effects
Food Hypersensitivity / diagnosis,  etiology*,  therapy
Gastrointestinal Diseases / diagnosis,  etiology,  therapy
Humans
Infant
Patient Education as Topic
Chemical
Reg. No./Substance:
0/Allergens; 0/Anti-Asthmatic Agents; 0/Dietary Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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