Document Detail

8-Oxo-7,8-dihydro-2'-deoxyguanosine, reactive oxygen species and ambulatory blood pressure in African and Caucasian men: The SABPA study.
MedLine Citation:
PMID:  25096646     Owner:  NLM     Status:  Publisher    
Abstract Various studies indicate a relationship between increased oxidative stress and hypertension resulting in increased DNA damage and consequent excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG). The aim of this study was to compare urinary 8-oxodG levels in African and Caucasian men and to investigate the association between ambulatory blood pressure (BP) and pulse pressure (PP) with 8-oxodG in these groups. We included 98 African and 92 Caucasian men and determined their ambulatory BP and PP. Biochemical analyses included, urinary 8-oxodG, reactive oxygen species (ROS) (measured as serum peroxides), ferric reducing antioxidant power (FRAP), total glutathione (GSH), glutathione peroxidase (GPx) and glutathione reductase (GR) activity. The African men had significantly higher systolic (SBP) and diastolic blood pressure (DBP) (both p<0.001). Assessment of the oxidative stress markers indicated significantly lower 8-oxodG levels (p<0.001) in the African group. The African men also had significantly higher ROS (p=0.002) with concomitant lower FRAP (p<0.001), while their GSH levels (p=0.013) and GR activity (p<0.001) were significantly higher. Single and partial regression analyses indicated a negative association between urinary 8-oxodG levels with SBP, DBP and PP only in African men. These associations were confirmed in multiple regression analyses (SBP: R(2)=0.41; β=-0.25; p=0.002, DBP: R(2)=0.30; β=-0.21; p=0.022, PP: R(2)=0.30; β=-0.19; p=0.03). Our results revealed significantly lower urinary 8-oxodG in African men which was accompanied by a negative association with BP and PP. We propose that this may indicate a dose-response relationship in which increased oxidative stress may play a central role in the up-regulation of antioxidant defence and DNA repair mechanisms.
Catharina M C Mels; Aletta E Schutte; Rudolph Schutte; Pieter J Pretorius; Wayne Smith; Hugo W Huisman; Francois H van der Westhuizen; Carla M T Fourie; Johannes M van Rooyen; Ruan Kruger; Roan Louw; Nicolaas T Malan; Leoné Malan
Related Documents :
8509996 - The oral antihypertensive activity of the methylated derivatives of phenyl-2-aminoethyl...
8428406 - The use of transdermal clonidine in the hypertensive patient with chronic renal failure.
15448876 - Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneo...
3748886 - Investigations of central interaction of ethanol and clonidine.
18840806 - Arterial stiffness and cognition in elderly persons with impaired glucose tolerance and...
6331226 - High-pressure stopped-flow spectrometry at low temperatures.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-6
Journal Detail:
Title:  Free radical research     Volume:  -     ISSN:  1029-2470     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-23     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse...
Next Document:  miR?222 regulates sorafenib resistance and enhance tumorigenicity in hepatocellular carcinoma.