| 8-Methoxypsoralen cream plus targeted narrowband ultraviolet B for psoriasis. | |
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MedLine Citation:
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PMID: 17100735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Targeted ultraviolet (UV) phototherapy is a recent addition to the therapeutic armamentarium for the treatment of localized psoriasis. Topical psoralens enhance the therapeutic effects of UV-based treatment for various dermatoses, but have never been used in conjunction with targeted UVB. PURPOSE: To compare the efficacy of targeted narrowband UVB phototherapy (NB-UVB) alone with that of the combination of 0.1% 8-methoxypsoralen cream and targeted NB-UVB phototherapy (8-MOP/NB-UVB) for the treatment of plaque-type psoriasis. METHODS: Two areas within the same lesion of stable psoriasis were randomized to receive either targeted NB-UVB alone or 8-MOP/NB-UVB. Fluences of UVB delivered were held constant at four minimal erythema doses. The treatments were continued until lesions cleared or 12 treatments. Follow-ups were done until lesional scores returned to 50% of the baseline values. RESULTS: Ten patients completed this study. Four lesions were cleared by 8-MOP/NB-UVB while three were cleared by NB-UVB alone. The improvement in disease activity as reflected by psoriasis severity index score during treatment was statistically significantly better in the combination group (P=0.005). Mean remission time of lesions which were cleared by 8-MOP/NB-UVB was 8 weeks while that for lesions that were cleared by NB-UVB alone was 4.67 weeks. CONCLUSION: We concluded that addition of 0.1% 8-MOP cream to targeted narrowband UVB significantly enhances the therapeutic effects of the light treatment without increasing the incidence of adverse effects. |
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Authors:
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Noppadol Amornpinyokeit; Pravit Asawanonda |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Photodermatology, photoimmunology & photomedicine Volume: 22 ISSN: 0905-4383 ISO Abbreviation: Photodermatol Photoimmunol Photomed Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-14 Completed Date: 2007-02-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013641 Medline TA: Photodermatol Photoimmunol Photomed Country: Denmark |
Other Details:
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Languages: eng Pagination: 285-9 Citation Subset: IM |
Affiliation:
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Division of Dermatology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Adolescent Adult Combined Modality Therapy Dermatologic Agents / administration & dosage, therapeutic use* Female Humans Male Methoxsalen / administration & dosage, therapeutic use* Middle Aged Psoriasis / drug therapy*, pathology, radiotherapy* Severity of Illness Index Treatment Outcome Ultraviolet Rays* |
| Chemical | |
Reg. No./Substance:
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0/Dermatologic Agents; 298-81-7/Methoxsalen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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