Document Detail

8-Hydroxy-2-(di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors.
MedLine Citation:
PMID:  17609739     Owner:  NLM     Status:  MEDLINE    
The effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) on food intake were investigated in food-deprived rats. 8-OH-DPAT (25-100 microg/kg) administered subcutaneously immediately prior to the presentation of food produced a dose-related decrease in food intake in rats that had been fasted for 22 h. The hypophagic effect of 8-OH-DPAT (50 microg/kg) was abolished by pretreatment with the selective 5-HT1A receptor antagonist n-[2-(4-2-methoxyphenyl)-1-piperazinyl]-n-(2-pyridyl) cyclohexanecarboxamide (WAY 10063; 0.3 mg/kg). The results of this study show that the acute dose-dependent depressant effect of 8-OH-DPAT on food intake in fasted rats is mediated by an action at 5-HT1A receptors.
I S Ebenezer; M J Arkle; R M Tite
Related Documents :
3963799 - Suppression of drinking but not feeding by central eledoisin and physalaemin in the rat.
9164599 - Influenza virus infection of mice induces anorexia: comparison with endotoxin and inter...
19490369 - The anorectic effect of neuropeptide af is associated with satiety-related hypothalamic...
134899 - Hyperactivity induced by tetrahydroisoquinoline derivatives injected into the nucleus a...
22832679 - Chewing time and chewing strokes in different dentofacial deformities.
9246559 - How constant is an individual's route of heroin administration? data from treatment and...
23444709 - Lessons learned from national food fortification projects: experiences from morocco, uz...
16151739 - In vitro antiparasitic activity of extracts of cardiospermum halicacabum against third-...
17257249 - In vitro anti-malassezia activity of xanthorrhizol isolated from curcuma xanthorrhiza r...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  29     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-07-04     Completed Date:  2007-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  269-72     Citation Subset:  IM    
Copyright Information:
(c) 2007 Prous Science. All rights reserved.
Neuropharmacology Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire, England, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
8-Hydroxy-2-(di-n-propylamino)tetralin / administration & dosage,  pharmacology*
Appetite Depressants / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Eating / drug effects*
Fasting / metabolism*
Food Deprivation
Injections, Subcutaneous
Piperazines / pharmacology
Pyridines / pharmacology
Receptor, Serotonin, 5-HT1A / drug effects*,  metabolism
Serotonin Agonists / administration & dosage,  pharmacology*
Serotonin Antagonists / pharmacology
Time Factors
Reg. No./Substance:
0/Appetite Depressants; 0/Piperazines; 0/Pyridines; 0/Serotonin Agonists; 0/Serotonin Antagonists; 112692-38-3/Receptor, Serotonin, 5-HT1A; 146714-97-8/WAY 100635; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Development of granulocyte and monocyte adsorptive apheresis in the rat dextran sodium sulfate-induc...
Next Document:  The effects of opioids, local anesthetics and adjuvants on isolated pregnant rat uterine muscles.