Document Detail


8-Hydroxy-2-(di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors.
MedLine Citation:
PMID:  17609739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) on food intake were investigated in food-deprived rats. 8-OH-DPAT (25-100 microg/kg) administered subcutaneously immediately prior to the presentation of food produced a dose-related decrease in food intake in rats that had been fasted for 22 h. The hypophagic effect of 8-OH-DPAT (50 microg/kg) was abolished by pretreatment with the selective 5-HT1A receptor antagonist n-[2-(4-2-methoxyphenyl)-1-piperazinyl]-n-(2-pyridyl) cyclohexanecarboxamide (WAY 10063; 0.3 mg/kg). The results of this study show that the acute dose-dependent depressant effect of 8-OH-DPAT on food intake in fasted rats is mediated by an action at 5-HT1A receptors.
Authors:
I S Ebenezer; M J Arkle; R M Tite
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  29     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-07-04     Completed Date:  2007-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  269-72     Citation Subset:  IM    
Copyright Information:
(c) 2007 Prous Science. All rights reserved.
Affiliation:
Neuropharmacology Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire, England, UK. ivor.ebenezer@port.ac.uk
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MeSH Terms
Descriptor/Qualifier:
8-Hydroxy-2-(di-n-propylamino)tetralin / administration & dosage,  pharmacology*
Animals
Appetite Depressants / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Eating / drug effects*
Fasting / metabolism*
Food Deprivation
Injections, Subcutaneous
Male
Piperazines / pharmacology
Pyridines / pharmacology
Rats
Receptor, Serotonin, 5-HT1A / drug effects*,  metabolism
Serotonin Agonists / administration & dosage,  pharmacology*
Serotonin Antagonists / pharmacology
Time Factors
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Piperazines; 0/Pyridines; 0/Serotonin Agonists; 0/Serotonin Antagonists; 112692-38-3/Receptor, Serotonin, 5-HT1A; 146714-97-8/WAY 100635; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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