Document Detail


The 7th workshop on the assessment of adequate intake of dietary amino acids: summary of general discussion.
MedLine Citation:
PMID:  18806123     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Extensive discussion sessions were held at the end of each of the 2 d of the workshop. Through the course of the workshop, it became clear that there were different opinions on how to use uncertainty factors to obtain upper levels of intake from no observed adverse effect levels of a particular nutrient and that the selection of an appropriate uncertainty factor would be rather arbitrary. Much of the discussion centered around the potential for using metabolic limits, expressed as the level of intake at which the major pathway of metabolism may approach saturation and at which the amino acid is metabolized by alternative pathways, as a measurable early or surrogate marker for amino acid excess and possible toxicity. After extensive discussion on various conditions that would need to be satisfied for metabolic limits to be used as markers of excessive intake of amino acids, there was a general consensus that methods such as measuring oxidation limits are an attractive approach that merit future investigation. It was noted that there are many data on the clinical use of glutamine, whereas data for proline are very scarce. There was recognition that regardless of the available data, there is regulatory pressure for setting upper levels of intake for amino acids and that much more data are required.
Authors:
Takeshi Kimura; Andrew G Renwick; Motoni Kadowaki; Luc A Cynober
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  138     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-22     Completed Date:  2008-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2050S-2205S     Citation Subset:  IM    
Affiliation:
Ajinomoto Co., Inc., Quality Assurance and External Scientific Affairs Department, 104-8315 Tokyo, Japan. takeshi_kimura@ajinomoto.com
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism*
Animals
Diet*
Health Status
Humans
Models, Animal
Nutrition Assessment*
Chemical
Reg. No./Substance:
0/Amino Acids

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