| [79-year-old patient with pulmorenal syndrome]. | |
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MedLine Citation:
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PMID: 20922641 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HISTORY AND ADMISSION FINDINGS: A 79-year-old female patient was referred with acute renal failure requiring haemodialysis and haemoptysis. INVESTIGATIONS: Kidney biopsy showed extracapillary proliferative glomerulonephritis with crescents in 7 from 15 glomeruli and sclerosis in the remaining. A computed tomography scan of the chest showed evidence of alveolar haemorrhage. Serologic testing revealed autoantibodies against the glomerular basement membrane (anti-GBM antibodies) and myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA). DIAGNOSIS, TREATMENT AND COURSE: The patient was diagnosed with goodpasture's disease and underwent immunosuppressive therapy including prednisolone, cyclophosphamide pulses and plasmapheresis, resulting in clearance of anti-GBM antibodies and discontinuation of haemoptysis. Renal function, however, did not recover and the patient remained on dialysis. CONCLUSIONS: Aggressive treatment including cyclophosphamide and plasma separation often ensures patient survival in goodpasture's disease, in most cases, however, renal function does not recover. |
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Authors:
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Ferruh Artunc; Christiane Dorn; Frank Gehlen; Maike Büttner; Kerstin Amann; Peter Weyrich; Nils Heyne; Sabine Wolf |
Publication Detail:
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Type: Case Reports; English Abstract; Journal Article Date: 2010-10-04 |
Journal Detail:
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Title: Deutsche medizinische Wochenschrift (1946) Volume: 135 ISSN: 1439-4413 ISO Abbreviation: Dtsch. Med. Wochenschr. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2010-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0006723 Medline TA: Dtsch Med Wochenschr Country: Germany |
Other Details:
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Languages: ger Pagination: 1982 Citation Subset: IM |
Affiliation:
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Medizinische Klinik, Universitätsklinikum Tübingen, Tübingen, Germany. ferruh.artunc@med.uni-tuebingen.de |
Vernacular Title:
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Pulmorenales Syndrom bei einer 79-jährigen Patientin. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anti-Glomerular Basement Membrane Disease / diagnosis*, immunology, pathology, therapy Antibodies, Antineutrophil Cytoplasmic / blood Autoantibodies / blood Biopsy Combined Modality Therapy Cyclophosphamide / therapeutic use Female Hemoptysis / etiology*, pathology Humans Immunoglobulin G / analysis Immunosuppressive Agents / therapeutic use Kidney / pathology Kidney Failure, Acute / etiology*, pathology Microscopy, Fluorescence Peroxidase / immunology Plasmapheresis Prednisolone / therapeutic use Prognosis Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antineutrophil Cytoplasmic; 0/Autoantibodies; 0/Immunoglobulin G; 0/Immunosuppressive Agents; 0/antiglomerular basement membrane antibody; 50-18-0/Cyclophosphamide; 50-24-8/Prednisolone; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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