Document Detail


The 769G>A variant of the inhibin-alpha gene in Korean patients with preeclampsia.
MedLine Citation:
PMID:  18852530     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Increased inhibin A serum and plasma levels in the second trimester are significantly associated with the development of preeclampsia. The measurement of inhibin A during early pregnancies may be helpful to predict those at risk of this disorder. The purpose of this study was to determine whether the 769G>A variant of the inhibin alpha (INHalpha) gene was associated with preeclampsia. PATIENTS AND METHODS: We screened the 769G>A variation in 162 preeclamptic patients and in 202 normal pregnancies. The 769G>A variant of the INHalpha gene was determined by the PCR-based restriction fragment length polymorphism analysis and DNA sequencing. RESULTS: We found no variation between the normal subjects and the preeclamptic patients. CONCLUSION: The 769G>A variant of the INHalpha gene may be rare in Korean patients with preeclampsia.
Authors:
S Y Kim; J-H Lim; J-H Yang; M-Y Kim; M-H Kim; S-Y Park; H-M Ryu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  31     ISSN:  1720-8386     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-10-14     Completed Date:  2009-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  700-3     Citation Subset:  IM    
Affiliation:
The Laboratory of Medical Genetics, Cheil General Hospital and Women's Healthcare Center, Kwandong University School of Medicine, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Base Sequence
DNA Mutational Analysis
Female
Gene Frequency
Humans
Inhibins / genetics*
Korea
Maternal Age
Molecular Sequence Data
Point Mutation
Polymorphism, Restriction Fragment Length*
Pre-Eclampsia / genetics*
Pregnancy
Chemical
Reg. No./Substance:
0/inhibin-alpha subunit; 57285-09-3/Inhibins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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