| The 769G>A variant of the inhibin-alpha gene in Korean patients with preeclampsia. | |
| | |
MedLine Citation:
|
PMID: 18852530 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Increased inhibin A serum and plasma levels in the second trimester are significantly associated with the development of preeclampsia. The measurement of inhibin A during early pregnancies may be helpful to predict those at risk of this disorder. The purpose of this study was to determine whether the 769G>A variant of the inhibin alpha (INHalpha) gene was associated with preeclampsia. PATIENTS AND METHODS: We screened the 769G>A variation in 162 preeclamptic patients and in 202 normal pregnancies. The 769G>A variant of the INHalpha gene was determined by the PCR-based restriction fragment length polymorphism analysis and DNA sequencing. RESULTS: We found no variation between the normal subjects and the preeclamptic patients. CONCLUSION: The 769G>A variant of the INHalpha gene may be rare in Korean patients with preeclampsia. |
| | |
Authors:
|
S Y Kim; J-H Lim; J-H Yang; M-Y Kim; M-H Kim; S-Y Park; H-M Ryu |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of endocrinological investigation Volume: 31 ISSN: 1720-8386 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2008 Aug |
Date Detail:
|
Created Date: 2008-10-14 Completed Date: 2009-02-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
|
Languages: eng Pagination: 700-3 Citation Subset: IM |
Affiliation:
|
The Laboratory of Medical Genetics, Cheil General Hospital and Women's Healthcare Center, Kwandong University School of Medicine, Seoul, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Base Sequence DNA Mutational Analysis Female Gene Frequency Humans Inhibins / genetics* Korea Maternal Age Molecular Sequence Data Point Mutation Polymorphism, Restriction Fragment Length* Pre-Eclampsia / genetics* Pregnancy |
| Chemical | |
Reg. No./Substance:
|
0/inhibin-alpha subunit; 57285-09-3/Inhibins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients wit...
Next Document: Somatostatin analogs and gallstones: a retrospective survey on a large series of acromegalic patient...