Document Detail

766 cases of oral cleft in Italy. Data from Emilia Romagna (IMER) and northeast Italy (NEI) registers.
MedLine Citation:
PMID:  7859843     Owner:  NLM     Status:  MEDLINE    
Epidemiological and genetic variables for oral clefts were analysed for the years 1981-1989 in a case-control study of congenital malformations in the Emilia Romagna, Veneto, and Friuli regions, and in the Trento and Bolzano hospitals. Birth prevalence for all cases of cleft lip with or without cleft palate (CL(P)) was 8.2 per 10,000 births, and that for cleft palate only (CP) was 6.1 per 10,000. Coexisting abnormalities were found in 23% of CL(P) cases and in 43% of CP. No clusters in time or space were detected. For isolated clefts, a predominance of males among CL(P) and of females among CP was found; epilepsy was the only maternal risk factor correlated with clefts, and an association between clefting and consanguinity was found. Empirical recurrence risks were calculated in both isolated CL(P) and CP.
M Milan; G Astolfi; S Volpato; G P Garani; M Clementi; R Tenconi; S Boni; E Calzolari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of epidemiology     Volume:  10     ISSN:  0393-2990     ISO Abbreviation:  Eur. J. Epidemiol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1995-03-23     Completed Date:  1995-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8508062     Medline TA:  Eur J Epidemiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  317-24     Citation Subset:  IM    
Instituto di Genetica Medica-Universita' di Ferrara.
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MeSH Terms
Abnormalities, Multiple / epidemiology
Case-Control Studies
Chi-Square Distribution
Cleft Palate / epidemiology*,  genetics*
Confidence Intervals
Infant, Newborn
Italy / epidemiology
Risk Factors
Sex Distribution

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