| 72-h kinetics of high-sensitive troponin T and inflammatory markers after marathon. | |
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MedLine Citation:
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PMID: 21448080 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: Strenuous exercise induces significant increases in cardiac biomarkers. However, it is still unclear whether this is caused by cardiomyocyte necrosis or secondary mechanisms such as ischemia, cardiac energy deficiency, increased inflammation, or renal dysfunction. METHODS: Therefore, we investigated cardiac biomarkers (hs-cTnT, NT-proBNP, h-FABP), inflammation markers (hs-CRP, IL-6, IL-10, TNF-α) and renal function (cystatin C) in 102 healthy men aged 42 (±9) years before and 0h, 24h and 72h after a marathon. RESULTS: Kinetics of hs-cTnT revealed a peak immediately after the race (V3) that decreased rapidlyto pre-test values within 72h (V5) (median (interquartile range IQR): 31.07 (19.25-46.86) ng/L at V3 and 3.61 (3.20-6.70) ng/L at V5; p<0.001). NT-proBNP and h-FABP kinetics showed a similar pattern (NT-proBNP = 92.6 (56.9-149.7) ng/L at V3 and 34.9 (21.7-54.5) ng/L at V5; h-FABP = 44.99 (32.19-64.42) μg/L at V3 and 7.66 (5.64-10.60) μg/L at V5; p always <0.001). Pro-inflammatory markers such as IL-6 and hs-CRP, and renal dysfunction were significantly augmented immediately post-race race (pre-race compared to maximum post-race: IL-6: 15.5-fold, hs-CRP: 28-fold, cystatin C: 1.22-fold, all p<0.001). These increases were not related to the increase of hs-cTnT. Similarly, training history, finishing time and exercise intensity were not associated with changes of hs-cTnT. CONCLUSION: Cardiac biomarkers were increased immediately after a marathon race. Interestingly, values returned to normal levels within 72h. These kinetics with a sharp peak indicate that cardiac necrosis during marathon running seems very unlikely, but may be explained by altered myocyte metabolism. |
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Authors:
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Johannes Scherr; Siegmund Braun; Tibor Schuster; Charlotte Hartmann; Stefan Moehlenkamp; Bernd Wolfarth; Axel Pressler; Martin Halle |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-25 |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: - ISSN: 1530-0315 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Department of Prevention and Sports Medicine, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany 2Institute for Laboratory Medicine, Deutsches Herzzentrum Muenchen der Technischen Universitaet Muenchen, Munich, Germany 3Department for Medical Statistics and Epidemiology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany 4Department of Cardiology, University Hospital, Essen, Germany. |
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