| 7.2% NaCl/10% dextran 60 versus 20% mannitol for treatment of intracranial hypertension. | |
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MedLine Citation:
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PMID: 7526628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Severe head injury is frequently associated with extracranial injuries causing hemorrhagic hypotension. Volume replacement with isotonic fluids not only is therapeutically of limited efficacy but may aggravate posttraumatic brain edema. On the other side, hypertonic/hyperoncotic saline/dextran solution (HHS) shown to restore cardiovascular function in hemorrhagic shock instantaneously, was found to decrease intracranial pressure in experimental head injury. Currently the therapeutic efficacy of HHS and mannitol on ICP was compared at 24 hrs after a focal cerebral lesion and inflation of an epidural balloon in rabbits. Both solutions given at an equimolar dose rapidly lowered the ICP. After the first injection, ICP reduction was longer maintained with mannitol (189 +/- 27 min) as compared to HHS (98 +/- 14 min), while no difference in duration of lowering ICP was found after the second injection. Due to its blood pressure effects, HHS afforded a higher cerebral perfusion pressure than mannitol. In animals with HHS, the water content of the traumatized hemisphere was increased while the contralateral hemisphere was dehydrated. With mannitol, no differences in water content were found between the injured and uninjured hemisphere. The efficiency of HHS in hemorrhagic shock and intracranial hypertension render the fluid mixture particularly promising in patients with polytrauma in combination with head injury. |
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Authors:
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S Berger; L Schürer; R Härtl; T Deisböck; C Dautermann; R Murr; K Messmer; A Baethmann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta neurochirurgica. Supplementum Volume: 60 ISSN: 0065-1419 ISO Abbreviation: Acta Neurochir Suppl (Wien) Publication Date: 1994 |
Date Detail:
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Created Date: 1994-12-01 Completed Date: 1994-12-01 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0140560 Medline TA: Acta Neurochir Suppl (Wien) Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 494-8 Citation Subset: IM |
Affiliation:
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Institute for Surgical Research, Ludwig-Maximilians-University, München, Federal Republic of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects, physiology Blood-Brain Barrier / drug effects, physiology Brain Edema / physiopathology, therapy* Brain Injuries / physiopathology, therapy* Cerebral Cortex / injuries, physiopathology Dextrans / administration & dosage* Intracranial Pressure / drug effects, physiology Mannitol / administration & dosage* Pseudotumor Cerebri / physiopathology, therapy* Rabbits Saline Solution, Hypertonic / administration & dosage* Shock, Hemorrhagic / physiopathology, therapy Water-Electrolyte Balance / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Saline Solution, Hypertonic; 69-65-8/Mannitol; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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