Document Detail

Seventy-two-hour preservation, resuscitation, and transplantation of an isolated rat heart with high partial pressure carbon monoxide gas (PCO = 400 hPa) and high partial pressure carbon dioxide (PCO(2) = 100 hPa).
MedLine Citation:
PMID:  20525434     Owner:  NLM     Status:  MEDLINE    
The cardiac cavity of an isolated rat heart was filled with a Krebs-Henseleit (KH) solution, and the heart was hung in a high-pressure chamber. After the high-pressure chamber had been filled with a mixed gas (PCO = 400 hPa, PCO(2) = 100 hPa, PO(2) = 900 hPa, PHe = 5600 hPa) and preserved for 72 h, we performed a cervical ectopic heart transplantation on a recipient rat and resuscitated the preserved heart. This is the first incidence in the world of a mammalian organ having been successfully preserved and resuscitated after 72 h via a desiccation method.
Naoyuki Hatayama; Yu Yoshida; Kunihiro Seki
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Publication Detail:
Type:  Journal Article     Date:  2010-06-03
Journal Detail:
Title:  Cell transplantation     Volume:  19     ISSN:  1555-3892     ISO Abbreviation:  Cell Transplant     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-19     Completed Date:  2011-01-31     Revised Date:  2012-09-14    
Medline Journal Info:
Nlm Unique ID:  9208854     Medline TA:  Cell Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  707-12     Citation Subset:  IM    
Resonance Club Co, Ltd, Tokyo, Japan.
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MeSH Terms
Carbon Dioxide / pharmacology*
Carbon Monoxide / pharmacology*
Heart / drug effects*
Heart Transplantation / methods*
Organ Preservation / methods*
Partial Pressure
Resuscitation / methods*
Time Factors
Reg. No./Substance:
124-38-9/Carbon Dioxide; 630-08-0/Carbon Monoxide
Erratum In:
Cell Transplant. 2012;21(2-3):623

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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