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A 7-nitrobenz-2-oxa-1,3-diazole based highly sensitive and selective turn-on chemosensor for copper(ii) ion with intracellular application without cytotoxicity.
MedLine Citation:
PMID:  23354441     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A 7-nitrobenz-2-oxa-1,3-diazole (NBD) derived turn-on fluorescent probe () exhibits a reversible binding to Cu(2+) ion in presence of other metal ions, giving ∼20 fold increase in fluorescence intensity. The apparent association constant (K(a)) for Cu(2+) was found to be 2.62 × 10(4) M(-1). The intracellular Cu(2+) imaging behaviour of chemosensor on HeLa cells studied by fluorescence microscopy revealed that after incubation with cells exhibited intensive fluorescence when exogenous Cu(2+) was introduced into the cell. Thus this probe features the ready availability, high sensitivity and selectivity towards Cu(2+) in MeCN-H(2)O (1 : 1, v/v) with cell imaging possibilities with no or negligible cytotoxicity.
Authors:
Tarun Mistri; Rabiul Alam; Malay Dolai; Sushil Kumar Mandal; Anisur Rahman Khuda-Bukhsh; Mahammad Ali
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  -     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry, Jadavpur University, Kolkata 700 032, India.
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