| 7-Tesla MR imaging of non-melanoma skin cancer samples: correlation with histopathology. | |
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MedLine Citation:
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PMID: 22118136 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: The aims of this study were to compare in vitro magnetic resonance imaging (MRI) characteristics of keratinocytic skin cancer assessed by a 7-tesla (T) MRI with histopathology, and to describe MRI features of skin tumors. METHODS: This prospective study included 30 skin tumors treated by surgery. MR images of skin samples were acquired on a 7-T MR scanner using a fast spin-echo T(2) -weighted and an isotropic 3D gradient-echo T(1) -weighted sequence. Length, width, Breslow index and margins of the lesions were measured. The presence or absence of the following was noted: healthy margins, ulceration of the dermis, in situ lesions, superficial and deep dermis involvement, subcutaneous involvement, superficial and intratumoral keratin. MR results were compared to histopathology. RESULTS: Interclass correlation coefficient (ICC) was very good for the evaluation of the width (ICC = 0.86) and Breslow index (ICC = 0.87). The ICC was good for the evaluation of the margins (ICC = 0.70) but for length, ICC was lower (ICC = 0.67). Mean bias between MRI and histopathology was inferior to 1 mm for width, Breslow index and margin. CONCLUSION: In vitro 7-T MRI of keratinocytic skin cancer allows delineation of lesions with good correlation with histopathology. After in vivo confirmation it could have a diagnostic role regarding the delineation of surgical margins but its actual limitations prevent its practical adoption at this time. |
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Authors:
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Sébastien Aubry; Olga Leclerc; Luc Tremblay; Edmond Rizcallah; Frédéric Croteau; Charles Orfali; Martin Lepage |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-24 |
Journal Detail:
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Title: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) Volume: - ISSN: 1600-0846 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504453 Medline TA: Skin Res Technol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Department of Radiology, University Hospital of Besançon, Besançon, France; Department of Radiology, University Hospital of Sherbrooke, Sherbrooke, QC, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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