| 7-Nitroindazole potentiates c-fos expression induced by muscle tendon vibration in the spinal cord. | |
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MedLine Citation:
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PMID: 22431094 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction: Expression of c-fos initiated by muscle proprioceptive signaling was studied in rats after inhibition of neuronal nitric oxide synthase (nNOS) with administration of 7-nitroindazole (7-NI). Methods: Fos-immunoreactive (Fos-ir) neurons were visualized immunohistochemically in the lumbar cord after vibration of the Achilles tendon and/or 7-NI systemic injections. Results: The total number of Fos-ir interneurons and motoneurons (per slice) was significantly greater in the 7-NI-pretreated and tendon-vibrated (7-NI + Tv) group than in the isolated tendon vibration group (Tv group). The greatest increases in the number of Fos-ir neurons were found in the L4 (+100%) and L5 (+105%) segments (P < 0.05). Conclusions: Suppression of NO release after introduction of 7-NI was associated with potentiation of Fos immunoreactivity induced by muscle proprioceptive signaling within distinctive regions of the spinal cord. Muscle Nerve, 2012. |
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Authors:
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Alexander I Pilyavskii; Vladimir A Maisky; Andrey V Maznychenko; Alexander I Kostyukov |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Muscle & nerve Volume: 45 ISSN: 1097-4598 ISO Abbreviation: Muscle Nerve Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 597-602 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Department of Movement Physiology, Bogomoletz Institute of Physiology, National Academy of Sciences, Bogomoletz Str. 4, Kiev 01024, Ukraine. pil@biph.kiev.ua. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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