| "7, 10 and 14-days rabeprazole-based standard triple therapies for H. pylori eradication: are they still effective? A randomized trial". | |
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MedLine Citation:
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PMID: 22103045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PATIENTS AND METHODS: 307 patients, from 2 endoscopic centers in Greece, were randomized to receive Rabeprazole 20 mg bid, Clarithromycin 500 mg bid, and Amoxycillin 1gr bid for 7-days, for 10-days or for 14-days. Cure rates were assessed by CLO-test and histology. Clarithromycin sensitivity tests were carried out in the cultured pre-treatment H.pylori strains. The success rates were calculated by both intention-to-treat (ITT) and per protocol (PP) analyses. RESULTS: The eradication rates according to ITT analyses were 74.5% (95% CI: 66.5-82.9%) for 7-days, 80.6% (95% CI: 73.2-88.2%) for 10-days and 90.2% (95% CI: 84.5-95.9%) for 14-days treatment. PP cure rates were 76% (95% CI: 68.4-85.0%) for 7-days, 83% (95% CI: 76.6-91.0%) for 10-days and 93.9% (95% CI: 86.7-973%) for 14-days treatment. Side effects were generally minor and comparable in all treatment groups. CONCLUSIONS: Both 10- and 14-days rabeprazole-based triple regimens reached eradication rates above the threshold of 80% on an intention to treat basis. In our setting, the current regimen using rabeprazole, amoxicillin and clarithromycin was well tolerated, is still effective and should continue to be recommended as first-line therapy for H. pylori eradication. |
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Authors:
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S Karatapanis; S D Georgopoulos; V Papastergiou; L Skorda; N Papantoniou; Ph Lisgos; C Kouvidou; P Fragkou; A Mentis |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Acta gastro-enterologica Belgica Volume: 74 ISSN: 0001-5644 ISO Abbreviation: Acta Gastroenterol. Belg. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-11-22 Completed Date: 2011-12-20 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0414075 Medline TA: Acta Gastroenterol Belg Country: Belgium |
Other Details:
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Languages: eng Pagination: 407-12 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, General Hospital of Rhodes, Greece. stylkar@otenet.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles
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administration & dosage* Adult Aged Amoxicillin / administration & dosage Anti-Bacterial Agents / administration & dosage* Anti-Ulcer Agents / administration & dosage* Clarithromycin / administration & dosage Drug Therapy, Combination Female Helicobacter Infections / drug therapy* Helicobacter pylori / drug effects* Humans Male Middle Aged Young Adult |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 26787-78-0/Amoxicillin; 32828355LL/rabeprazole; 81103-11-9/Clarithromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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