| 68Ga-citrate PET/CT for evaluating patients with infections of the bone: preliminary results. | |
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MedLine Citation:
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PMID: 21078801 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: We enrolled 31 patients with suspected osteomyelitis or diskitis who underwent a total of forty (68)Ga-citrate PET/CT scans. The results were compared with different combinations of diagnostic procedures (MRI, radiography, CT, or white blood cell scintigraphy), biopsy (when diagnostic), and follow-up data (at least 1 y) to determine the performance of (68)Ga-citrate PET/CT. RESULTS: We found a sensitivity of 100%, a specificity of 76%, a positive predictive value of 85%, a negative predictive value of 100%, and an overall accuracy of 90%. CONCLUSION: Although preliminary, these data confirm a possible role for (68)Ga-citrate in the diagnosis of bone infections, especially in consideration of its favorable characteristics. |
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Authors:
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Cristina Nanni; Costantino Errani; Luca Boriani; Lorenzo Fantini; Valentina Ambrosini; Stefano Boschi; Domenico Rubello; Cinzia Pettinato; Mario Mercuri; Alessandro Gasbarrini; Stefano Fanti |
Publication Detail:
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Type: Journal Article Date: 2010-11-15 |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 51 ISSN: 1535-5667 ISO Abbreviation: J. Nucl. Med. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1932-6 Citation Subset: IM |
Affiliation:
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Medicina Nucleare, Azienda Ospedaliero-Universitaria di Bologna, Policlinico S Orsola-Malpighi, Bologna, Italy. cristina.nanni@aosp.bo.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anti-Bacterial Agents / therapeutic use Biopsy Bone Diseases, Infectious / drug therapy, radionuclide imaging*, surgery Citric Acid / diagnostic use*, pharmacokinetics Discitis / drug therapy, radionuclide imaging, surgery Female Gallium Radioisotopes / diagnostic use Humans Male Middle Aged Osteomyelitis / drug therapy, radionuclide imaging, surgery Positron-Emission Tomography / methods* Predictive Value of Tests Radiopharmaceuticals / diagnostic use*, pharmacokinetics Reproducibility of Results Tissue Distribution Tomography, Emission-Computed / methods* Whole-Body Counting Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Gallium Radioisotopes; 0/Radiopharmaceuticals; 77-92-9/Citric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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