Document Detail

6,7-Difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid, a newly designed fluorescence enhancement-type derivatizing reagent for amino compounds.
MedLine Citation:
PMID:  20108029     Owner:  NLM     Status:  MEDLINE    
A novel fluorescence enhancement-type derivatizing reagent for amino compounds, 6,7-difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid (FMQC), was developed. FMQC reacts with aliphatic primary amino compounds to afford strong fluorescent derivatives having high photo-and thermo-stabilities. The FMQC derivatives of amino compounds showed 12-159 times higher fluorescence quantum efficiencies than those of FMQC in aqueous and polar organic media. Additionally, the absorption and fluorescence emission wavelength of the derivatives are red-shifted from those of FMQC. These differences in the fluorescence properties between FMQC and the fluorescent derivative enabled the simple and highly sensitive determination of amino compounds without removing any excess unreacted FMQC by using a simple spectrofluorometer as well as HPLC.
Junzo Hirano; Kenji Hamase; Hiroyuki Miyata; Kiyoshi Zaitsu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-28
Journal Detail:
Title:  Journal of fluorescence     Volume:  20     ISSN:  1573-4994     ISO Abbreviation:  J Fluoresc     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-06-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9201341     Medline TA:  J Fluoresc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  615-24     Citation Subset:  IM    
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
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MeSH Terms
Amines / chemistry*
Carboxylic Acids / chemical synthesis,  chemistry*
Chromatography, High Pressure Liquid
Diethylamines / chemistry
Propylamines / chemistry
Quinolines / chemical synthesis,  chemistry*
Spectrometry, Fluorescence
Water / chemistry
Reg. No./Substance:
0/6,7-difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid; 0/Amines; 0/Carboxylic Acids; 0/Diethylamines; 0/Morpholines; 0/Propylamines; 0/Quinolines; 109-89-7/diethylamine; 6504-57-0/tiemonium methylsulfate; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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