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613 cases of splenic rupture without risk factors or previously diagnosed disease: a systematic review.
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PMID:  22889306     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Rupture of the spleen in the absence of trauma or previously diagnosed disease is largely ignored in the emergency literature and is often not documented as such in journals from other fields. We have conducted a systematic review of the literature to highlight the surprisingly frequent occurrence of this phenomenon and to document the diversity of diseases that can present in this fashion.
METHODS: Systematic review of English and French language publications catalogued in Pubmed, Embase and CINAHL between 1950 and 2011.
RESULTS: We found 613 cases of splenic rupture meeting the criteria above, 327 of which occurred as the presenting complaint of an underlying disease and 112 of which occurred following a medical procedure. Rupture appeared to occur spontaneously in histologically normal (but not necessarily normal size) spleens in 35 cases and after minor trauma in 23 cases. Medications were implicated in 47 cases, a splenic or adjacent anatomical abnormality in 31 cases and pregnancy or its complications in 38 cases. The most common associated diseases were infectious (n = 143), haematologic (n = 84) and non-haematologic neoplasms (n = 48). Amyloidosis (n = 24), internal trauma such as cough or vomiting (n = 17) and rheumatologic diseases (n = 10) are less frequently reported. Colonoscopy (n = 87) was the procedure reported most frequently as a cause of rupture. The anatomic abnormalities associated with rupture include splenic cysts (n = 6), infarction (n = 6) and hamartomata (n = 5). Medications associated with rupture include anticoagulants (n = 21), thrombolytics (n = 13) and recombinant G-CSF (n = 10). Other causes or associations reported very infrequently include other endoscopy, pulmonary, cardiac or abdominal surgery, hysterectomy, peliosis, empyema, remote pancreato-renal transplant, thrombosed splenic vein, hemangiomata, pancreatic pseudocysts, splenic artery aneurysm, cholesterol embolism, splenic granuloma, congenital diaphragmatic hernia, rib exostosis, pancreatitis, Gaucher's disease, Wilson's disease, pheochromocytoma, afibrinogenemia and ruptured ectopic pregnancy.
CONCLUSIONS: Emergency physicians should be attuned to the fact that rupture of the spleen can occur in the absence of major trauma or previously diagnosed splenic disease. The occurrence of such a rupture is likely to be the manifesting complaint of an underlying disease. Furthermore, colonoscopy should be more widely documented as a cause of splenic rupture.
Authors:
F Kris Aubrey-Bassler; Nicholas Sowers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-08-14
Journal Detail:
Title:  BMC emergency medicine     Volume:  12     ISSN:  1471-227X     ISO Abbreviation:  BMC Emerg Med     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-05-31     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  100968543     Medline TA:  BMC Emerg Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  11     Citation Subset:  IM    
Affiliation:
Primary Healthcare Research Unit, Memorial University of Newfoundland, Health Sciences Centre, St, John's, Newfoundland and Labrador, St Johns, Canada. kaubrey@mun.ca
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MeSH Terms
Descriptor/Qualifier:
Databases, Bibliographic
Diagnosis, Differential
Emergency Medical Services / methods,  statistics & numerical data*
Humans
Rupture, Spontaneous / diagnosis*,  etiology
Splenic Rupture / diagnosis*,  etiology*
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal ID (nlm-ta): BMC Emerg Med
Journal ID (iso-abbrev): BMC Emerg Med
ISSN: 1471-227X
Publisher: BioMed Central
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Copyright ©2012 Aubrey-Bassler and Sowers; licensee BioMed Central Ltd.
open-access:
Received Day: 9 Month: 2 Year: 2012
Accepted Day: 28 Month: 7 Year: 2012
collection publication date: Year: 2012
Electronic publication date: Day: 14 Month: 8 Year: 2012
Volume: 12First Page: 11 Last Page: 11
PubMed Id: 22889306
ID: 3532171
Publisher Id: 1471-227X-12-11
DOI: 10.1186/1471-227X-12-11

613 cases of splenic rupture without risk factors or previously diagnosed disease: a systematic review
F Kris Aubrey-Bassler123 Email: kaubrey@mun.ca
Nicholas Sowers4 Email: nbsowers@gmail.com
1Primary Healthcare Research Unit, Memorial University of Newfoundland, Health Sciences Centre, St. John’s, Newfoundland and Labrador, St Johns, Canada
2Discipline of Emergency Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, St Johns, Canada
3Discipline of Family Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, St Johns, Canada
4Department of Emergency Medicine, Dalhousie University, Halifax, NS, Canada

Background

Rupture of the spleen is relatively common both immediately and in a delayed fashion following significant blunt abdominal injury [1], and this phenomenon is well documented in the scientific literature and textbooks (e.g. [2,3]). While less common, cases of atraumatic rupture of diseased spleens are also widely reported in the literature (reviewed in [4,5]). In contrast, the phenomenon of splenic rupture in the absence of these two risk factors is not documented in emergency medicine textbooks [2,3] and we believe that it is not widely appreciated by emergency physicians.

Cases of splenic rupture not fitting the description above are related by their lack of historical cues to suggest the diagnosis at presentation. This distinguishes them from other causes of splenic rupture and highlights the importance to emergency physicians who rely a great deal on the patient history to appropriately triage patients for definitive investigation and referral. A recent systematic review of cases of atraumatic rupture of the spleen has been published [4]; however, a surprising number of the splenic rupture cases reported in this review and elsewhere represent the presenting complaint of the underlying disease process. The authors of the review do not highlight this fact which we believe to be crucial information to the practicing clinician. Therefore, we have reviewed the literature on cases of splenic rupture for which there was not an immediately obvious cause apparent on presentation such as significant trauma (either recent or remote) or previously diagnosed disease known to affect the spleen.


Methods

We conducted a systematic review of English and French language papers indexed in CINAHL, PubMed and Embase using the medical subject heading (MeSH) search terms “rupture, spontaneous,” and “splenic rupture,” (or equivalent for the different databases) combined with the textword search “undiagnosed” or “first manifestation” or “presenting” or “spontaneous.” This search strategy was combined with an additional strategy including the MeSH terms “rupture, spontaneous” and “spleen” and the free text “normal spleen;” both strategies were used together to extract relevant papers. Searches were limited to English and French language papers on human subjects published in the years 1950 to 2011. We also explored multiple other textword modifiers such as “atraumatic,” “non-traumatic” and “trivial,” none of which improved the sensitivity of the search with sufficient specificity to be helpful. Searches were developed by a research librarian and one of the authors who has training in clinical epidemiology (KA).

The reference lists of the papers so identified were also examined for relevant additions. We elected to include papers written in other languages if an English language abstract was available that included the information necessary for our report. Because the information we were trying to extract was fairly straightforward, we elected to include cases from papers for which only the abstract was available to us if the necessary information was reported there.

Case reports and case series’ were examined for relevance. Data was extracted from cases referenced in review papers only if the original paper was not available to us, and these were cross-referenced with case reports to prevent duplicate recording. Papers pertaining to the rupture of diseased spleens were excluded if the disease was correctly diagnosed prior to presentation at the emergency department. Cases of splenic rupture occurring immediately following any trauma (including trivial) were also excluded. Delayed splenic rupture cases were excluded if they occurred greater than 48 hours after major trauma (because this phenomenon is well reported in the literature and textbooks), but were included if the inciting traumatic event was considered by the two authors to be of trivial severity. Although the degree of trauma is debatable, we elected to include cases likely caused by cough or vomiting because we felt that these aetiologic factors were also under-appreciated. Although delayed post-medical procedure rupture of the spleen is documented in the proceduralist (surgical and GI) literature, it is not documented in EM textbooks and we have elected to include these cases here. We limited our report to papers published since 1950. Although the diagnosis and treatment of splenic rupture has changed considerably in recent years, we found no evidence to suggest that the underlying causes of rupture have changed during this time period. Because the primary purpose of our paper was to highlight aetiology and not diagnosis or management, we elected to choose a somewhat broader time period than might have been appropriate for a study with a different purpose. The information extracted onto a spreadsheet included the splenic disease process if any, other evidence of splenic abnormality (anatomical or histological), and the nature of any associated trauma. Causative processes were grouped into clinically relevant categories. We did not attempt to document histological or pathological findings, or review diagnostic or treatment methods as these are recently reviewed in detail elsewhere [4,5].


Results

No Medical Subject Headings or other keywords reliably identified the 396 papers reporting 607 cases of splenic rupture that met our inclusion criteria. Thus, we manually reviewed many abstracts and papers that ended up being excluded from this review (Figure 1). Some case series referenced here report both cases meeting our inclusion criteria and others meeting our exclusion criteria; only those meeting the inclusion criteria are included. We attempted to obtain all of the original papers referenced here so that we could document the cases without relying on secondary sources. However, sixteen of the papers were not accessible to us nor were we able to find the information necessary to fully ascertain whether the cases described within them were appropriate for this review. All cases are categorized in Figure 2 and clinically relevant sub-categories are presented in Tables  1, 2, 3, 4, 5, 6.


Discussion

Although rupture of the spleen in the absence of previously diagnosed disease or trauma is widely described as rare, given the extensive reports in the literature documented here, we believe that this descriptor should no longer be used. Although its existence is debated [1,369,400-402], sufficient reports from multiple authors are available to strongly suggest that rupture can occur spontaneously in otherwise normal spleens, but that this phenomenon is very rare. Given these two facts, the emergency clinician must be attuned to the possibility of splenic rupture in patients presenting with compatible symptoms without a compatible history. ED physicians must also be aware that such a presentation is very likely to be the manifesting episode of an underlying disease or anatomical abnormality. In the only other reference to these surprising findings, Renzulli found that the underlying cause for 51.2 % of the cases of atraumatic splenic rupture was not elicited until after hospital presentation [4].

In 1958, Orloff and Peskin proposed four criteria to define a true spontaneous rupture of a spleen [206], which emphasize that the spleen must appear grossly and histologically normal. In the same paper, they cite 71 reports documenting ruptures of the spleen labelled as spontaneous, only 20 of which fulfilled all of their criteria. Thus, usage of the term spontaneous was inconsistent and continues to be so in the more recent literature, with many authors labeling the rupture of diseased spleens as spontaneous. We highlight this because many of the pathological ruptures that we have documented here (as well as pathological ruptures in patients with previously known disease documented elsewhere [6]) include the word spontaneous in the title and no information on the associated pathology   [8,61,91,98,124,151,154,355-357,365,400,403]. Thus, readers skimming titles may be mistaken in thinking that true spontaneous rupture is more common than thought.

As we have shown here, documentation of rupture of the spleen following colonoscopy is relatively common with at least 87 cases reported (Table 2). However, we found only 1 such case reported in the emergency medicine literature [9], and no reference to this association in emergency medicine textbooks [2,3] or electronic resources [404]. Although many occurrences of these cases should be evident to the endoscopist at the time of or shortly after the procedure, at least 8 documented cases have presented to the ED greater than 48 hours afterwards [10,11,21-23]. We have therefore elected to include these and other post-procedure cases in this review. Rupture of the spleen after other procedures appears to be very rare.

For the cases presented here with pathology in addition to the splenic rupture, there is a plausible causative relationship between the other pathology and the rupture for the vast majority. However, we have also included cases with a less clear patho-physiological relationship, such as the case reported 3 years after a pancreato-renal transplant [253], and that associated with viral hepatitis but no cirrhosis [113]. We acknowledge that the association in these cases may be coincidental and thus that these cases may better be classified as spontaneous. Although Wilson’s disease does not typically affect the spleen directly, the likely pathologic mechanism of the rupture in the case reported here is splenomegaly caused by portal hypertension [229].

We found only one case of delayed rupture of a normal spleen following trivial trauma reported in the literature in the last 60 years [392]. One other report of such a rupture in an enlarged but otherwise normal spleen [249], and reports of three others do not include information on the presence of splenic disease [393-395]. One additional case has been reported in a man 14 days after a mild fall, but the patient had also just been given heparin for a presumed myocardial infarction [396]. Given the dearth of publication in this area, the possibility remains that the associations observed in these reports are coincidental rather than causational. Regardless of the causative mechanism, these cases still meet the inclusion criteria for this review.

Limitations

The primary goal of this paper is to highlight the occurrence of splenic rupture in patients without risk factors apparent on history. A secondary purpose is to document the diverse nature of illnesses that can present in this manner. However, we have not attempted to obtain papers that were not available to us either electronically, on paper at our library or through inter-library loan. We also have not attempted to have non-English or non-French language abstracts or papers translated. The possibility remains therefore that we have missed some rare causes of splenic rupture. In addition, while a general estimate of the relative frequency of different causes of splenic rupture can be made from the numbers reported here, the numbers for those that are frequently reported such as colonoscopy, malaria and lymphoma are likely underestimated because of publication bias. Conversely, the relative frequencies of rupture for rare or novel causes are likely over-estimated.


Conclusions

Both traumatic and pathological rupture of the spleen are frequently reported in journals and documented in textbooks of emergency medicine. However, other causes of rupture are largely ignored in the emergency literature. We have documented a diverse range of patients for whom the presenting complaint for a disease was rupture of the spleen. We have also documented a number of medical procedures and medications that appear to have contributed to a rupture of the spleen, including some that have presented after the patients had been discharged from the facility conducting the procedure. Finally, we have documented several cases of trivial trauma associated with splenic rupture. Although these categories at first glance seem unrelated, they share the characteristic of having causes of rupture that would either be very subtle or completely unapparent on the presenting history, and are thus directly relevant to the practicing emergency physician. We hope that increased awareness of these phenomena will improve the ability of emergency clinicians to diagnose similar cases of splenic rupture in a timely fashion.


Competing interests

The authors declare that they have no competing interests.


Authors’ contributions

Both authors were involved in the literature search, review of the papers for inclusion, and the drafting of and revisions to the manuscript. KA takes full responsibility for the content. Both authors read and approved the final manuscript.


Pre-publication history

The pre-publication history for this paper can be accessed here:

http://www.biomedcentral.com/1471-227X/12/11/prepub


Acknowledgements

The authors wish to thank Shahil Sood for his assistance with some of the paper reviews and Ms Alison Farrell for her assistance with the literature search. This research was conducted with funding from the Primary Healthcare Research Unit and the Faculty of Medicine both at Memorial University of Newfoundland.

Author details

1Primary Healthcare Research Unit, Memorial University of Newfoundland, Health Sciences Centre, St. John’s, Newfoundland and Labrador, St Johns, Canada. 2Discipline of Emergency Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, St Johns, Canada.3Discipline of Family Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, St Johns, Canada. 4Department of Emergency Medicine, Dalhousie University, Halifax, NS, Canada.


References
Olsen WR,Polley TZ Jr,A Second Look at Delayed Splenic RuptureArch SurgYear: 1977112442242510.1001/archsurg.1977.01370040074012849149
Tintinalli JE,Kelen GD,Stapczynski JS,Emergency Medicine: A Comprehensive Study GuideYear: 20046McGraw Hill, New York
Stone CK,Humphries RL,CURRENT Diagnosis & Treatment: Emergency Medicine6 available at: http://www.accessmedicine.com/content.aspx?aID=3099123.: Access Medicine; 2011.
Renzulli P,Hostettler A,Schoepfer AM,Gloor B,Candinas D,Systematic review of atraumatic splenic ruptureBr J SurgYear: 200996101114112110.1002/bjs.673719787754
Debnath D,Valerio D,Atraumatic rupture of the spleen in adultsJ R Coll Surg EdinbYear: 20024743744511874265
Renzulli P,Schoepfer A,Mueller E,Candinas D,Atraumatic splenic rupture in amyloidosisAmyloidYear: 2009161475310.1080/1350612080267692219291515
Moher D,Liberati A,Tetzlaff J,Altman D,Antes G,Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statementPLoS MedYear: 200967e100009710.1371/journal.pmed.100009719621072
Randriamarolahy A,Cucchi JM,Brunner P,Garnier G,Demarquay J,Bruneton JN,Two rare cases of spontaneous splenic ruptureClin ImagingYear: 201034430630810.1016/j.clinimag.2009.09.00420630345
Meier RPH,Toso C,Volonte F,Mentha G,Splenic rupture after colonoscopyAm J Emerg MedYear: 201129242 e1-242.e2.
Saad A,Rex DK,Colonoscopy-induced splenic injury: Report of 3 cases and literature reviewDig Dis SciYear: 20085389289810.1007/s10620-007-9963-517934832
Petersen CR,Adamsen S,Gocht-Jensen P,Arnesen RB,Hart-Hansen O,Splenic injury after colonoscopyEndoscopyYear: 200840767910.1055/s-2007-96694018058621
DeVries J,Ronnen HR,Oomen APA,Linskens RK,Splenic rupture following colonoscopy, a rare complicationNeth J MedYear: 200967623023319749393
Arnaud JP,Bergamaschi R,Casa C,Boyer J,Splenic rupture: unusual complication of colonoscopyColo-proctologyYear: 19936356357
Guerra JF,San Francisco I,Pimentel F,Ibanez L,Splenic rupture following colonoscopyWorld J GastroenterolYear: 200814416410641210.3748/wjg.14.641019009661
Janes SEJ,Cowan IA,Dijkstra B,A life threatening complication after colonoscopyBMJYear: 2005330749688910.1136/bmj.330.7496.88915831876
Lalor PF,Mann BD,Splenic rupture after colonoscopyJ Soc Laparoendocsopic SurgeonsYear: 200711151156
Rao KV,Beri GD,Sterling MJ,Salen G,Splenic injury as a complication of colonoscopy: a case seriesAm J GastroenterolYear: 200910461604160519491881
Sarhan M,Ramcharan A,Ponnapalli S,Splenic injury after elective colonoscopyJ Soc Laparoendocsopic SurgeonsYear: 200913616619
Tse CCW,Chung KM,Hwang JST,Prevention of splenic injury during colonoscopy by positioning the patientEndoscopyYear: 1998307475
Wiedmann MW,Kater F,Bohm B,Splenic rupture following endoscopic polypectomyZ GastroenterolYear: 201048447647810.1055/s-0028-110960520352593
Ahmed A,Eller PM,Schiffman FJ,Splenic rupture: an unusual complication of colonoscopyAm J GastroenterolYear: 199792120112049219800
Merchant AA,Cheng EH,Delayed splenic rupture after colonoscopyAm J GastroenterolYear: 19908579069072371998
Taylor FC,Frankl HD,Riemer KD,Late presentation of splenic trauma after routine colonoscopyAm J GastroenterolYear: 19898444424432486056
Zyromski NJ,Camp CM,Splenic Injury: A Rare Complication of Endoscopic Retrograde CholangiopancreatographyAm SurgYear: 200470873773915328812
Lewis FW,Moloo N,Stiegmann GV,Goff JS,Splenic injury complicating therapeutic upper gastrointestinal endoscopy and ERCPGastrointest EndoscYear: 19913763263310.1016/S0016-5107(91)70872-91756925
Furman G,Morgenstern L,Splenic injury and abscess complicating endoscopic retrograde cholangiopancreatographySurg EndoscYear: 1993734334410.1007/BF007259548351610
Kingsley D,Schermer C,Jamal M,Rare complications of endoscopic retrograde cholangiopancreatography: wo case reportsJSLSYear: 2001517117311394431
Tronsden E,Roseland AR,Moer A,Solheim K,Rupture of the spleen following endoscopic retrograde cholangiopancreotography (ERCP)Acta Chir ScandYear: 198915575762929211
Ong E,Bohmler U,Wurgs D,Splenic injury as a complication of endoscopy: two case reports and a literature reviewEndoscopyYear: 19912330230410.1055/s-2007-10106951743138
Lo AY,Washington M,Fischer MG,Splenic trauma following endoscopic retrograde cholangiopancreatography (ERCP)Surg EndoscYear: 1994869269310.1007/BF006785698059310
Wu WC,Katon RM,Injury to the liver and spleen after diagnostic ERCPGastrointest EndoscYear: 19933982482710.1016/S0016-5107(93)70278-38293913
Baradaran S,Mischinger HJ,Bacher J,Werkgartner G,Karpf E,Linck FG,Spontaneous splenic rupture during portal triad clampingLangenbecks Arch ChirYear: 19953802662687500797
Ben-Haim M,Emre S,Fishbein T,Sheiner PA,Miller CM,Schwartz ME,Spontaneous splenic rupture during hepatic inflow occlusion (Pringle maneuver) or total vascular isolationLiver TransplYear: 20006C19 Abstract 77.
Douzdjian V,Broughan TA,Spontaneous splenic rupture during total vascular occlusion of the liverBr J SurgYear: 19958240640710.1002/bjs.18008203437796027
Baniel J,Bihrle R,Wahle GR,Foster RS,Splenic rupture during occlusion of the porta hepatis in resection of tumors with vena caval extensionJ UrolYear: 19941519929948126847
Kling N,Bechstein WO,Steinmüller T,Raakow R,Jonas S,Spontaneous splenic rupture during Pringle maneuvre in liver resection for hepatic abscessActa Chir AustrYear: 19993126126310.1007/BF02620180
Klotz S,Semik M,Senninger N,Berendes E,Scheld HH,Spontaneous splenic rupture after a left-side thoracotomy: Report of a caseSurg TodayYear: 200333863663810.1007/s00595-003-2535-112884106
Stupnik T,Vidmar S,Hari P,Spontaneous rupture of a normal spleen following bronchoplastic left lung lower lobectomyInteract Cardiovasc Thorac SurgYear: 2008729029118202025
Hunter RCJ,Gastroscopy and delayed rupture of the spleen; a review and report of a possible caseGastroenterologyYear: 19552989890613270819
delos Santos CA,von Eye O,Vila D,Mottin CC,Rupture of the spleen: A complication of continuous ambulatory peritoneal dialysisPerit Dial IntYear: 198664203204
Marcuzzi D,Gray R,Wesley-James T,Symptomatic splenic rupture following extracorporeal shock wave lithotripsyJ UrolYear: 19911455475481997706
Ernst D,Ruptured spleen after electric convulsion therapyBMJYear: 19802807637370645
Johnson N,Traumatic rupture of the spleen: a review of eighty-five casesANZ J SurgYear: 195424211212410.1111/j.1445-2197.1954.tb05079.x
Chang MY,Shiau CS,Chang CL,Hou HC,Chiang CH,Hsieh TT,Soong YK,Spleen laceration, a rare complication of laparoscopyJ Am Assoc Gyecol LaparoscYear: 200072267272
Bahli ZM,Kennedy K,Post hysterectomy spontaneous rupture of spleenJ Ayub Med Coll AbbottabadYear: 200921318118320929044
Hoffman RL,Rupture of the spleen: a review and report of a case following abdominal hysterectomyAm J Obstet GynecolYear: 19721135245304636630
Habek D,Cerkez Habek J,Spontaneous splenic rupture of the spleen following abdominal hysterectomyZentralbl GynakolYear: 200112358858910.1055/s-2001-1908611753814
Heidenreich W,Mlasowsky B,Spontaneous splenic rupture as a cause of postoperative hemorrhageGeburtshilfe FrauenheilkdYear: 19864691091110.1055/s-2008-10363453817412
Hamel CT,Blum J,Harder F,Kocher T,Nonoperative treatment of splenic rupture in malaria tropica: review of literature and case reportActa TropYear: 20028211510.1016/S0001-706X(02)00025-611904097
Imbert P,Rapp C,Buffet PA,Pathological rupture of the spleen in malaria: Analysis of 55 cases (1958–2008)Travel Med Infect DisYear: 20097314715910.1016/j.tmaid.2009.01.00219411041
Patel MI,Spontaneous rupture of a malarial spleen 16Med J AustYear: 199315911–128368378264491
Ozsoy MF,Oncul O,Pekkafali Z,Pahsa A,Yenen OS,Splenic complications in malaria: Report of two cases from TurkeyJ Med MicrobiolYear: 200453121255125810.1099/jmm.0.05428-015585506
Zingman BS,Viner BL,Splenic complications in malaria: Case report and reviewClin Infect DisYear: 199316222323210.1093/clind/16.2.2238443301
Yagmur Y,Hamdi Kara I,Aldemir M,Buyukbayram H,Tacyildiz IH,Keles C,Spontaneous rupture of malarial spleen: two case reports and review of literatureCrit CareYear: 2000430931310.1186/cc71311056757
Gupta N,Lal P,Vindal A,Hadke NS,Khurana N,Spontaneous rupture of malarial spleen presenting as hemoperitoneum: a case reportJ Vector Borne DisYear: 20104711912020539052
Mokashi AJ,Shirahatti RG,Prabhu SK,Vagholkar KR,Pathological rupture of malarial spleenJ Postrad MedYear: 1992383141142
John BV,Ganesh A,Aggarwal S,Clement E,Persistent hypotension and splenic rupture in a patient with Plasmodium vivax and faciparum co-infectionJ Postgrad MedYear: 2004501808115048011
Rubio PA,Berkman NL,Rupture of the spleen in a Central American immigrantHosp PractYear: 19963118990
Clezy JK,Richens JE,Non-operative management of a spontaneously rupture malarial spleenBr J SurgYear: 19857299010.1002/bjs.18007212193910163
Adam I,Adam ES,Spontaneous splenic rupture in a pregnant Sudanese woman with Falciparum malaria: a case reportEast Mediter Health JYear: 200713735736
Tu AS,Tran MT,Larsen CR,Spontaneous splenic rupture: Report of five cases and a review of the literatureEmerg RadiolYear: 19974641541810.1007/BF01451078
Ali J,Spontaneous rupture of the spleen in patients with infectious mononucleosisCan J SurgYear: 199336149528443718
Coltheart G,Little JM,Splenectomy: A review of morbidityANZ J SurgYear: 1976461323610.1111/j.1445-2197.1976.tb03189.x
Hyun BH,Varga CF,Rubin RJ,Spontaneous and Pathologic Rupture of the SpleenAMA Arch SurgYear: 1972104565265710.1001/archsurg.1972.041800500280074503094
McMahon MJ,Lintott JD,Mair WSJ,Lee PWR,Duthie JS,Occult rupture of the spleenBr J SurgYear: 197764964164310.1002/bjs.1800640910588998
Alberty R,Surgical implications of infectious mononucleosisAm J SurgYear: 1981141555956110.1016/0002-9610(81)90048-97223948
Badura RA,Oliveira O,Palhano MJ,Borregana J,Quaresma J,Spontaneous rupture of the spleen as presenting even in infectious mononucleosisScan J Infec DisYear: 20013387287410.1080/003655401753186268
Bonsignore A,Grillone G,Soliera M,Fiumara F,Pettinato M,Calarco G,Angio LG,Licursi M,[Occult rupture of the spleen in a patient with infectious mononucleosis] ItalianG ChirYear: 2010313869020426918
Gauderer MWL,Stellato TA,Hutton MC,Splenic injury: Nonperative management in three patients with infectious mononucleosisJ Pediatr SurgYear: 198924111812010.1016/S0022-3468(89)80314-82723983
Gayer G,Zandman-Boddard G,Kosych E,Spontaneous rupture of the spleen detected on CT as the initial manifestation of infectious mononucleosisEmerg RadiolYear: 2003105115290533
Mavinamane S,Yadava R,Abood E,Spontaneous splenic rupture secondary to infectious mononucleosis [abstract]Eur J Intern MedYear: 200920S219S219
Patel JM,Rizzolo E,Hinshaw JR,Spontaneous subcapsular splenic hematoma as the only clinical manifestation of infectious mononucleosisJAMAYear: 19822473243324410.1001/jama.1982.033204800590277087065
Rotolo JE,Spontaneous splenic rupture in infectious mononucleosisAm J Emerg MedYear: 19875538338510.1016/0735-6757(87)90386-X3620036
Stephenson JT,DuBois JJ,Nonoperative management of spontaneous splenic rupture in infectious mononucleosis: A case report and review of the literaturePediatricsYear: 20071202e432e43510.1542/peds.2006-307117671047
Stockinger ZT,Infectious mononucleosis presenting as spontaneous splenic rupture without other symptomsMil MedYear: 2003168972272414529246
Szoko M,Matolcsy A,Kovacs G,Simon G,Spontaneous splenic rupture as a complication of symptom-free infections mononucleosisOrv HetilYear: 2007148291381138410.1556/OH.2007.2809417631473
Blaivas M,Quinn J,Diagnosis of spontaneous splenic rupture with emergency ultrasonogrophyAnn Emerg MedYear: 19983262763010.1016/S0196-0644(98)70046-09795331
Semrau F,Kühl R,Ritter K,Ruptured spleen and autoantibodies to superoxide dismutase in infectious mononucleosisLancetYear: 19963479008112411258602102
Johnson M,Cooperberg P,Boisvert J,Stoller J,Winrob H,Spontaneous splenic rupture in infectious mononucleosis: sonographic diagnosis and follow-upAm J RoentgenolYear: 198113611111146779555
Klinkert P,Kluit AB,Vries AC,Puylaert JBCM,Spontaneous Rupture of the Spleen: Role of Ultrasound in Diagnosis, Treatment, and MonitoringEur J SurgYear: 1999165771271310.1080/1102415995018980710452269
MacGowan JR,Mahendra P,Ager S,Marcus RE,Thrombocytopenia and spontaneous rupture of the spleen associated with infectious mononucleosisClin Lab HaematolYear: 19951793947621637
Miranti JP,Rendleman DF,Spontaneous rupture of the spleen as the presenting event in infectious mononucleosisJ Am Coll Health AssocYear: 1981309610.1080/07448481.1981.99388877320369
Gordon MK,Rietveld JA,Frizelle FA,The management of splenic rupture in infetious mononucleosisAust N Z J SurgYear: 19956524725010.1111/j.1445-2197.1995.tb00621.x7717942
Fleming WR,Spontaneous splenic rupture in infectious mononucleosisAust N Z J SurgYear: 19916138939010.1111/j.1445-2197.1991.tb00241.x2025194
Peters RM,Gordon LA,Nonsurgical treatment of splenic hemorrhage in an adult with infectious mononucleosis: Case report and reviewAm J MedYear: 198680112312510.1016/0002-9343(86)90061-63510538
Schuler JG,Filtzer H,Spontaneous Splenic Rupture: The Role of Nonoperative ManagementArch SurgYear: 1995130666266510.1001/archsurg.1995.014300601000207763176
Purkiss SF,Splenic rupture and infectious mononucleosis-splenectomy, splenorrhaphy or non operative managementJ R Soc MedYear: 19928584584591404193
Aswani V,Visekruna M,Atraumatic splenic rupture (abstract)Wisconsin Med JYear: 20081007247
Lum D,Infectious mononucleosisProc UCLA HealthcareYear: 2005913
Al-Mashat FM,Sibiany AM,Al Amri AM: Spontaneous splenic rupture in infectious mononucleosisSaudi J GastroenterolYear: 20039848619861813
Lieberman ME,Levitt MA,Spontaneous rupture of the spleen: A case report and literature reviewAm J Emerg MedYear: 198971283110.1016/0735-6757(89)90079-X2643958
Maillard N,Koenig M,Pillet S,Cuilleron M,Cathebras P,Spontaneous splenci rupture in primary cytomegalovirus infectionsLa Presse MedicaleYear: 20073687487710.1016/j.lpm.2007.02.01417363209
Rogues AM,Dupon M,Cales V,Malou M,Paty MC,Le Bail B,Lacut JY,Spontaneous splenic rupture: an uncommon complication of cytomegalovirus infectionJ InfectYear: 1994291838510.1016/S0163-4453(94)95195-07963640
Alliot C,Beets C,Besson M,Derolland P,Spontaneous splenic rupture associated with CMV infection: a report of a case and reviewScand J Infect DisYear: 20013387587710.1080/0036554011002711411760178
Ragnaud J,Morlat P,Gin H,Dupon M,Delafaye C,du Pasquier P,Aubertin J,Aspects cliniques, biologiques et évolutifs de l'infection à cytomégalovirus chez le sujet immunocompétent: à propos de 34 patients hospitalisésLa Revue de Médecine InterneYear: 19941511318
Ali G,Kamili MA,Rashid S,Mansoor A,Lone BA,Allaqaband GQ,Spontaneous splenic rupture in typhoid feverPostgrad Med JYear: 19947082551351410.1136/pgmj.70.825.5137937433
Julià J,Canet JJ,Martínez Lacasa X,González G,Garau J,Spontaneous spleen rupture during typhoid feverInt J Infect DisYear: 20004210810910.1016/S1201-9712(00)90104-810737849
Shivashankar GH,Kelly JF,Spontaneous splenic ruptureSurgery On-lineYear: 2007
Winearls JR,McGloughlin S,Fraser JF,Splenic rupture as a presenting feature of endocarditisEur J Cardiothorac SurgYear: 200935473773910.1016/j.ejcts.2008.12.04519217796
Llanwarne N,Badic B,Delugeau V,Landen S,Spontaneous splenic rupture associated with Listeria endocarditisAm J Emerg MedYear: 20072591086 e3-1086.e5. 18022517
Casanova-Roman M,Casas J,Sanchez-Porto A,Nacie B,Spontaneous rupture of the spleen associated with Legionella pneumoniaCan J Infect Dis Med MicrobiolYear: 2010213e107e10821886641
Saura P,Valles J,Jubert P,Ormaza J,Sequra F,Spontaneous rupture of the spleen in a patient with legionellosisClin Infect DisYear: 199317229810.1093/clinids/17.2.2988399896
Athey RJ,Barton LL,Horgan LF,Wood BH,Spontaneous splenic rupture in a patient with pneumonia and sepsisAcute MedicineYear: 20065212321655503
Barrier JH,Bani-Sadr F,Gaillard F,Raffi F,Spontaneous rupture of the spleen revealing primary human immunodeficiency virus infectionClin Infect DisYear: 199725233633710.1086/5169159332543
Mirchandani HG,Mirchandani IH,Pak MSY,Spontaneous rupture of the spleen due to AIDS in an IV drug abuserArch Pathol Lab MedYear: 1985109111411163840986
Vallabhaneni S,Scott H,Carter J,Treseler P,Machtinger EL,Atraumatic splenic rupture: an unusual manifestation of acute HIV infectionAIDS Patient Care STDSYear: 201125846146410.1089/apc.2011.013221711142
Henderson SA,Templeton JL,Wilkinson AJ,Spontaneous splenic rupture: a unique presentation of Q feverUlster Med JYear: 19885722182193232257
Baumbach A,Brehm B,Sauer W,Doller G,Hoffmeister HM,Spontaneous splenic rupture complicating acute Q feverAm J GastroenterolYear: 19928711165116531442694
Rest JG,Seid AS,Rogers D,Goldstein EJ,Pathologic rupture of the spleen due to Salmonella dublin infectionJ TraumaYear: 19852536636810.1097/00005373-198504000-000183989896
Benanti C,Arena L,Albertacci A,Rosso L,From spontaneous rupture of the spleen to septic shock in a case of salmonellosisActa Anaesth ItalicaYear: 200758182194
Lam KY,Ng WF,Chan ACL,Miliary tuberculosis with splenic rupture: A fatal case with hemophagocytic syndrome and possible association with long standing sarcoidosisPathologyYear: 199426449349310.1080/003130294001692627892057
Pramesh C,Tamhankar A,Rege S,Shah S,Splenic tuberculosis and HIV-1 infectionLancetYear: 2002359930335311830228
Lazaro EJ,Ong F,Parmer LP,Splenic rupture masquerading as acute appendicitisAm SurgYear: 1970367057085475690
Guleria S,Dorairajan LN,Sinha S,Khazanchi R,Bal S,Guleria R,Spontaneous rupture of spleen in viral hepatitis AIndian J GastroenterolYear: 199615308840627
Fonseca AG,Amaro M,Travancinha D,Barata J,A surprising virus spontaneous spleen rupture presenting EBV infection. Abstract 67.006Year: 200612th International Congress on Infectious Diseases (ICID), Lisbon Portugal
Tweed J,Tick trauma: tiny insect nearly did in veteran deputyBrainerd Daily DispatchYear: 2005 http://lymespot.blogspot.ca/2005_05_01_archive.html.
Dulger AC,Yilmaz M,Aytemiz E,Bartin K,Bulut MD,Kemik O,Sumer A,Spontaneous splenic rupture and hemoperitoneum due to brucellosis infection: A case reportVan Tip DergisiYear: 20111814144
Daybell D,Paddock CD,Zaki SR,Comer JA,Woodruff D,Hansen KJ,Peacock JE,Disseminated Infection with Bartonella henselae as a Cause of Spontaneous Splenic RuptureClin Infect DisYear: 2004393e21e2410.1086/42200115307019
Redondo MC,Rios A,Cohen R,Ayala J,Martinex J,Arellano G,et al. Hemmorhagic dengue with spontaneous splenic rupture: case report and reviewClin Infect DisYear: 1997251262126310.1086/5169719402405
Peiper M,Broering DC,Schroter M,Rogiers X,Rupture of the spleen associated with Enterobacter cloacaeActa Chir BelgYear: 199999858610352739
McKelvey SD,Braidley PC,Stansby GP,Weir WRC,Spontaneous splenic rupture associated with murine typhusJ InfectYear: 199122329629710.1016/S0163-4453(05)80017-92071915
Schmulewitz L,Moumile K,Patey-MariousdeSerre N,Poiree S,Gouin E,Mechai F,et al. Splenic rupture and malignant Mediterranean spotted feverEmerg Infect DisYear: 20081499599610.3201/eid1406.07129518507929
Vial I,Hamidou M,Coste-Burel M,Baron D,Abdominal pain in varicella: an unusual cause of spontaneous splenic ruptureEur J Emerg MedYear: 20041117617710.1097/01.mej.0000104026.33339.d515167182
Torricelli P,Coriani C,Marchetti M,Rossi A,Manenti A,Spontaneous rupture of the spleen: Report of two casesAbdom ImagingYear: 200126329029310.1007/s00261000015811429955
Andrews DF,Hernandez R,Grafton W,Williams DM,Pathologic rupture of the spleen in non-Hodgkin's lymphomaArch Intern MedYear: 1980140111912010.1001/archinte.1980.003301301210296986123
Dobashi N,Kuraishi Y,Kobayashi T,Hirano A,Isogai Y,Takagi K,Spontaneous splenic rupture in a case of non-Hodgkin's lymphomaRinsho KetsuekiYear: 19933421901938492417
Haj M,Zaina A,Wiess M,Cohen I,Joseph M,Horn I,Eitan A,Pathologic-spontaneous-rupture of the spleen as a presenting sign of splenic T-cell lymphoma - Case report with reviewHepatogastroenterologyYear: 1999462519319510228790
Lunning MA,Stetler-Stevenson M,Silberstein PT,Zenger V,Marti GE,Spontaneous (pathological) splenic rupture in a blastic variant of mantle cell lymphoma: A case report and literature reviewClin LymphomaYear: 20023211712010.3816/CLM.2002.n.01812435285
Mason KD,Juneja SK,Spontaneous rupture of the spleen as the presenting feature of the blastoid variant of mantle cell lymphomaClin Lab HaematolYear: 200325426326510.1046/j.1365-2257.2003.00522.x12890168
Opeskin K,Ellis D,Burke M,Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma presenting with spontaneous splenic rupturePathologyYear: 2004361949610.1080/0031302031000164359814757568
Salmi R,Guadenzi P,DiTodaro F,Morandi P,Nielsen I,Manfredini R,When a car accident can change the life: Splenic lymphoma and not post-traumatic haematomaIntern Emerg MedYear: 20083310071008
Strickland AH,Marsden KA,McArdle J,Lowenthal RM,Pathologic Splenic Rupture as the Presentation of Mantle Cell LymphomaLeuk LymphomaYear: 200141119710.3109/1042819010905797111342374
Zieren J,Paul M,Scharfenberg M,Müller JM,The spontaneous splenic rupture as first manifestation of mantle cell lymphoma, a dangerous rarityAm J Emerg MedYear: 200422762963110.1016/j.ajem.2004.09.01815666284
Biswas S,Keddington J,McClanathan J,Large B- cell lymphoma presenting as acute abdominal pain and spontaneous splenic rupture; a case report and review of relevant literatureWorld J Emerg SurgYear: 2006113510.1186/1749-7922-1-3517129392
Chen JH,Chan DC,Lee HS,Liu HD,Hsieh CB,Yu JC,Liu YC,Chen CJ,Spontaneous splenic rupture associated with hepatosplenic gammadelta T-cell lymphomaJ Formos Med AssocYear: 2005104859359616193182
Narasimhan P,Hitti IF,Gheewala P,Pulakhandam U,Kanzer B,Unusual presentations of lymphoma: Case 3. Splenic hematoma associated with non-Hodgkin's lymphomaJ Clin OncolYear: 2002201946194711919257
Thomson WHF,Diffuse lymphocytic lymphoma with splenic rupturePostgrad Med JYear: 196945505110.1136/pgmj.45.519.505819374
Chappuis J,Simoens C,Smets D,Duttmann R,Mendes da Costa P,Spontaneous rupture of the spleen in relation to a non-Hodgkin lymphonaActa Chir BelgYear: 200710744644817966545
Hebeda KM,MacKenzie MA,van Krieken JH,A case of anaplastic lymphoma kinase-positive anaplastic large cell lymphoma presenting with spontaneous splenic rupture: an extremely unusual presentationVirchows ArchYear: 200043745946410.1007/s00428000025111097375
Soria-Aledo V,Aguilar-Domingo M,Garcia-Cuadrado J,Carrasco-Prats M,Gonzalez-Martinez P,Spontaneous rupture of the spleen: a rare form of onset of non-Hodgkin's lymphomaRev Clin EspYear: 199919955255310522446
Roncella S,Cutrona G,Truini M,Airoldi I,Pezzolo A,Valetto A,Di Martino D,Dadati P,De Rossi A,Ulivi M,Fontana I,Nocera A,Valente U,Ferrarini M,Pistoia V,Late Epstein-Barr virus infection of a hepatosplenic gamma delta T-cell lymphoma arising in a kidney transplant recipientHaematologicaYear: 200085325626210702813
Tanaka M,Minato T,Yamamura Y,Katayama K,Ishikura H,Ichimori T,et al. A case of non-Hodgkin Lymphoma presenting with spontaneous splenic ruptureTokushima Red Cross Hospital Medical JournalYear: 2008139195
Matsui H,Andou S,Sakakibara K,Tsuji H,Uragami T,Karamatsu S,et al. A case of spontaneous splenic rupture due to malignant lymphomaJpn J Gastroenterol SurgYear: 1994272166217010.5833/jjgs.27.2166
Fausel R,Sun NCJ,Klein S,Splenic rupture in a human immunodeficiency virus-infected patient with primary splenic lymphomaCancerYear: 19906644241424162245398
Hoar FJ,Chan S,Stonelake PS,Wolverson RW,Bareford D,Splenic rupture as a consequence of dual malignant pathology: a case reportJ Clin PatholYear: 200356970971010.1136/jcp.56.9.70912944558
Brissette M,Dhru RD,Hodgkin's disease presenting as spontaneous splenic ruptureArch Pathol Lab MedYear: 199211610107710791417448
Dobrow RB,Spontaneous (pathologic) rupture of the spleen in previously undiagnosed Hodgkin's disease. Report of a case with survivalCancerYear: 197739135435810.1002/1097-0142(197701)39:1<354::AID-CNCR2820390154>3.0.CO;2-U832249
Saba HI,Garcia W,Hartmann RC,Spontaneous ruptur eof the spleen: an unusual presenting feature in Hodgkin's lymphomaSouth Med JYear: 19837624724910.1097/00007611-198302000-000276823604
Bloom RA,Freund V,Perkes EH,et al. Acute Hodgkin's disease masquerading as splenic abscessJ Surg OncolYear: 19811727928210.1002/jso.29301703107253662
Beshara FM,Spontaneous rupture of the spleen in Hodgkin's lymphomaClin OncolYear: 1982869717075047
Amonkar SJ,Kumar EN,Spontaneous rupture of the spleen: three case reports and causative processes for the radiologist to considerBr J RadiolYear: 200982e111e11310.1259/bjr/8144020619451309
Berrebi A,Bustan A,Mashiah A,Hurwitz N,Splenic rupture as a presenting sign of lymphoma of the spleenIsr J Med SciYear: 198420166676698774
Chow MS,Taylor MA,William Hanson C III,Splenic laceration associated with transesophageal echocardiographyJ Cardiothorac Vasc AnesthYear: 199812331431610.1016/S1053-0770(98)90013-19636915
Rhee SJ,Sheena Y,Imber C,Spontaneous rupture of the spleen: a rare but important differential of an acute abdomenAm J Emerg MedYear: 2008266733 e5-733.e6. 18606341
Altes A,Brunet S,Martinez C,Soler J,Ayats R,Sureda A,Lopez R,Domingo A,Spontaneous splenic rupture as the initial manifestation of acute lymphoblastic leukaemia: Immunophenotype and cytogeneticsAnn HematolYear: 199468314314410.1007/BF017274198167180
Banerjee PK,Bhansali A,Dash S,Dash RJ,Acute lymphoblastic leukaemia manifesting with splenic ruptureJ Assoc Physicians IndiaYear: 19903864344352384462
Bernat S,Garcia-Boyero R,Guinot M,Lopez F,Gozalbo T,Canigral G,Pathologic rupture of the spleen as the initial manifestation in acute lymphoblastic leukemiaHaematalogicaYear: 199883760761
Gibbs TJ,Sells RA,Bellingham AJ,A rare presentation of splenic rupturePostgrad Med JYear: 19775362140340510.1136/pgmj.53.621.403267912
Johnson CS,Rosen PJ,Sheehan WW,Acute lymphocytic leukemia manifesting as splenic ruptureAm J Clin PatholYear: 1979721118121287370
McEntee GP,Duignan JP,Otridge BW,Heffeman SJ,Acute lymphocytic leukaemia presenting as spontaneous splenic ruptureI J M SYear: 19841538284285
Donfrid M,Trisic B,Kraguljac N,Cemerikic V,Suvajdzic N,Colovic M,Subcapsular splenic hematoma as the initial manifestation of gammadelta + T-cell acute lymphoblastic leukaemiaHaemaYear: 200144951
Narang M,Sunita SS,Bhasin S,Sharma M,Gupta DK,Spontaneous splenic rupture - A rare initial manifestation of acute lymphoblastic leukemiaInd J Med Paediatr OncolYear: 2005266870
Gorosquieta A,Pérez-Equiza E,Gastearena J,[Asymptomatic pathological rupture of the spleen as the presenting form of acute lymphoblastic leukemiaSangre (Barc)Year: 1996412612628755218
Rodriguez-Luaces M,Jimenez HC,Lafuente GA,Mateos RP,Hernandez-Bajo JM,Pathological ruptue of the spleen as the initial manifestation of acute lymphoblastic leukemiaHaematologicaYear: 1998833833849592995
Carrasco CD,Yin JL,Spontaneous rupture of the spleen in a patient with B-cell acute lymphoblastic leukaemiaAnn HematolYear: 20058455555610.1007/s00277-005-1012-x15815909
Leuridan B,Sigam M,Callens J,Langeron P,Spontaneous rupture of the spleen revealing a chronic myeloid leukemiaJ Sci Med LilleYear: 197088105375415273931
Loza J,Egurbide I,Ramirez G,Spontaneous spleen rupture as presenting feature and cause of death in chronic myelogenous leukaemiaSangreYear: 19792417379284594
Pelosi AJ,Sinclair DJM,Spontaneous rupture of the spleen as the presenting feature of chronic myeloid leukemiaScott Med JYear: 19812643523536947433
Nestok BR,Goldstein JD,Lipkovic P,Splenic rupture as a cause of sudden death in undiagnosed chronic myelogenous leukemiaAm J Forensic Med PatholYear: 19889324124510.1097/00000433-198809000-000143177355
Wang JY,Lin YF,Lin SH,Tsao TY,Hemoperitoneum due to splenic rupture in a CAPD patient with chronic myelogenous leukemiaPerit Dial IntYear: 1998183343379663901
Marcos-Sánchez F,Juárez-Ucelay F,Aparicio-Martínez JC,Durán-Pérez NA,Stress angina, spontaneous rupture of the spleen and almost normal leukocyte values, a rare form of presentation of chronic myeloid leukosisAn Med InternaYear: 199185755761790293
Diebold J,Audoin J,Peliosis of the spleen. Report of a case associated with chronic myelomonocytic leukemia, presenting with spontaneous splenic ruptureAm J Surg PatholYear: 198371972046344667
Han J,Oh SY,Kim S,Kwon H,Hong SH,Han JY,Park K,Kim H,A case of pathologic splenic rupture as the initial manifestation of acute myeloid leukemia M2Yonsei Med JYear: 201051113814010.3349/ymj.2010.51.1.13820046528
Rajagopal A,Rmasamy R,Martin J,Acute myeloid leukemia presenting as splenic ruptureJ Assoc Physicians IndiaYear: 2002501435143712583479
Serur D,Terjanian T,Spontaneous rupture of the spleen as the initial manifestation of acute myeloid leukemiaN Y State J MedYear: 1992921601611594150
Tan A,Ziari M,Salman H,Ortega W,Cortese C,Spontaneous rupture of the spleen in the presentation of Acute Myeloid LeukemiaJ Clin OncolYear: 200725345519552010.1200/JCO.2007.13.175518048829
Sonobe H,Uchida H,Doi K,Shinozaki Y,Kunitomo T,Ogawa K,Spontaneous rupture of the spleen in acute myeloid leukemiaActa Pathol JpnYear: 19813123093186942631
Nagarsheth KH,Tucker B,Taylor D,Non-traumatic splenic rupture disguised as fall injuryInternet J SurgYear: 20102415p5p
Joubaud F,Gardais J,D'Aubigny N,Saint-Andre JP,Spontaneous rupture of the spleen in a patient with hairy cell leukemiaSemaine des HopitauxYear: 1985612014491451
Von Der Walde J,Mashiah A,Berrebi A,Tumores rari et inusitati. Spontaneous rupture of the spleen in hairy cell leukemiaClin OncolYear: 1981732412447343169
Ustün C,Sungur C,Akbas O,Sungur A,Gürgen Y,Ruacan S,et al. Spontaneous splenic rupture as the initial presentation of plasma cell leukemia: a case reportAm J HematolYear: 199857266267
Morla J,Masa L,Antela C,Barrio E,[Spontaneous rupture of the spleen as the form of presentation of hairy cell leukemia]Med Clin (Barc)Year: 1991961982033997
Minato E,Fujino I,Sugihira N,Matsumoto K,Shima K,Miki C,Spontaneous Splenic Rupture in a Case of Adult T Cell LeukemiaJpn J Gastroenterol SurgYear: 200336111571157410.5833/jjgs.36.1571
Saiers JH,Acute leukemia presenting as a ruptured spleen. Report of a caseRocky Mt Med JYear: 197774319320273297
Low SE,Stafford JS,Malignant histiocytosis: a case report of a rare tumour presenting with spontaneous splenic ruptureJ Clin PatholYear: 20065977077210.1136/jcp.2005.02787016803951
de Lajarte-Thirouard AS,Molina T,Audoin J,Le Tourneau A,Leduc F,Rose C,et al. Spleen localization of light chain deposition disease associated with sea blue histiocytosis, revealed by spontaneous ruptureVirchows ArchYear: 199943446346510.1007/s00428005036810389632
Gonday G,Delluc G,Demoures A,[Sea blue histiocyte syndrome. Disclosure by spontaneous splenic ruptureNouv Presse MedYear: 19821119497110949
Dawson PJ,Dawson G,Adult niemann-pick disease with sea-blue histiocytes in the spleenHum PatholYear: 198213121115112010.1016/S0046-8177(82)80249-96184303
Wilson CI,Cabello-Inchausti B,Sendzischew H,Robinson MJ,Ceroid histiocytosis: an unusual cause of traumatic splenic ruptureSouth Med JYear: 20019423723911235042
Rodon P,Ramain JP,Bruandet P,Piedon A,Akli J,Penot J,La maladie de Niemann-Pick type B avec syndrome des histiocytes bleu de merLa Revue de Médecine InterneYear: 1991124299302
Sherwood P,Sommers A,Shirfield M,Majumdar G,Spontaneous splenic rupture in uncomplicated multiple myelomaLeuk LymphomaYear: 1996205–65175198833414
Levy J,Spontaneous rupture of the spleen in association with idiopathic thrombocytopaenic purpuraPostgrad Med JYear: 1994702398183765
Sawlani KK,Gaiha M,Jain S,Shome DK,Aggarwal SB,Rani S,et al. Rare presentations of idiopathic myelofibrosis: spontaneous rupture of the spleen; pyoderma gangrenosum; and urologic obstructionJ Assoc Physicians IndiaYear: 19984623023211273121
Friedrich EB,Kindermann M,Link A,Böhm M,Splenic rupture complicating periinterventional glycoprotein IIb/IIIa antagonist therapy for myocardial infarction in polycythemia veraZ KardiolYear: 200594320020410.1007/s00392-005-0197-215747043
Sharma D,Sub-capsular splenectomy for delayed spontaneous splenic rupture in a case of sickle cell anemiaWorld J Emergency SurgeryYear: 2009411710.1186/1749-7922-4-17
Chim CS,Kwong YL,Shek TW,Ma SK,Ooi GC,Splenic rupture as the presenting symptom of blastic crisis in a patient with Philadelphia-negative, bcr-abl-positive ETAm J HematolYear: 2001661707110.1002/1096-8652(200101)66:1<70::AID-AJH1018>3.0.CO;2-H11426503
Franssen CFM,Ter Maaten JC,Hoorntje SJ,Spontaneous splenic rupture in Wegener's vasculitisAnnals of Rheumatic DiseaseYear: 19935231410.1136/ard.52.4.314
Hawley PH,Copland G,Zetler P,Spontaneous splenic rupture in c-ANCA positive vasculitisAust N Z J MedicineYear: 199626431432
McCain M,Quinet R,Davis W,Serebro L,Zakem J,Nair P,Ishaq S,Splenic rupture as the presenting manifestation of vasculitisSemin Arthritis RheumYear: 200231531131610.1053/sarh.2002.3063611965595
Fallingborg J,Lausten J,Winther P,Svanholm H,Atraumatic rupture of the spleen in periarteritis nodosaActa Chir ScandYear: 1985151185872858952
Ford GA,Bradley JR,Appleton DS,Spontaneous splenic rupture in polyarteritis nodosaPostgrad Med JYear: 19866273296596610.1136/pgmj.62.732.9652877455
Tolaymat A,Al-Mousily F,Haafiz AB,Lammert N,Afshari S,Spontaneous rupture of the spleen in a patient with systemic lupus erythematosusJ RheumatolYear: 199522234423458835573
Zimmerman-Gorska I,Bielaka K,Splenic rupture in the course of SLEPol Tyr LekYear: 19712619911992
Van de Voorde K,De Raeve H,De Block CE,Van Regenmortel N,Van Offel JF,De Clerck LS,Stevens WJ,Atypical systemic lupus erythematosus or Castleman's DiseaseAct Clin BelgYear: 200459161164
Pena JM,Garcia-Alegria J,Crespo M,Gijon J,Vazquez JJ,Spontaneous rupture of the spleen in rheumatoid arthritisAnn Rheum DisYear: 19844353910.1136/ard.43.3.5396742923
Orloff MJ,Peskin GW,Spontaneous rupture of the normal spleen; a surgical enigmaInt Abstr SurgYear: 1958106111113495867
Cubo T,Ramia JM,Pardo R,Martin J,Padilla D,Hernandez-Calvo J,Spontaneous rupture of the spleen in amyloidosisAm J Emerg MedYear: 199715444344410.1016/S0735-6757(97)90150-99217550
Gupta R,Singh G,Bose SM,Vaiphei K,Radotra B,Spontaneous rupture of the amyloid spleen: a report of two casesJ Clin GastroenterolYear: 19982616110.1097/00004836-199803000-000209563936
Oran B,Wright DG,Seldin DC,McAneny D,Skinner M,Sanchorawala V,Spontaneous rupture of the spleen in AL amyloidosisAm J HematolYear: 20037413113510.1002/ajh.1038914508801
Hurd WW,Katholi RE,Acquired Functional Asplenia: Association With Spontaneous Rupture of the Spleen and Fatal Spontaneous Rupture of the Liver in AmyloidosisArch Intern MedYear: 1980140684484510.1001/archinte.1980.003301801180357387282
Nowak G,Westermark P,Wernerson A,Herlenius G,Sletten K,Ericzon BG,Liver transplantation as rescue treatment in a patient with primary AL kappa amyloidosisTranspl IntYear: 200013929710.1111/j.1432-2277.2000.tb01047.x10836644
Okazaki K,Moriyasu F,Shiomura T,Yamamoto T,Suzaki T,Kanematsu Y,Akasaka S,Kobashi Y,Spontaneous rupture of the spleen and liver in amyloidosis - a case report and review of the literatureGastroenterol JpnYear: 19862155185243781175
Mumford AD,O'Donnell J,Gillmore JD,Manning RA,Hawkins PN,Laffan M,Bleeding symptoms and coagulation abnormalities in 337 patients with AL-amylodosisBr J HaematolYear: 200011045446010.1046/j.1365-2141.2000.02183.x10971408
Choufani EB,Sanchorawala V,Ernst T,Quillen K,Skinner M,Wright DG,Seldin DC,Acquired factor X deficiency in patients with amyloid light-chain amyloidosis: incidence, bleeding manifestations, and response to high-dose chemotherapyBloodYear: 20019761885188710.1182/blood.V97.6.188511238135
Tamarit Garcia JJ,Boluda Garcia F,Calvo Catala J,Campos Fernandez C,Parra Rodenas JV,Gonzalez Cruz ME,et al. [Spontaneous splenic rupture as an unusual presentation of primary amylodiosisRev Esp Enferm DigYear: 19999165365410502715
Roll GR,Lee AY,Royaie K,Visser B,Hanks DK,Knudson MM,Roll FJ,Acquired A amyloidosis from injection drug use presenting with atraumatic splenic rupture in a hospitalized patient: a case reportJ Med Case ReportsYear: 2011512910.1186/1752-1947-5-29
Rege JD,Kavishwar VS,Mopkar PS,Peliosis of spleen presenting as splenic rupture with haemoperitoneum-a case reportIndian J Pathol MicrobiolYear: 19984144654679866910
Etzion Y,Benharroch D,Saidel M,Riesenberg K,Gilad J,Schlaeffer F,Atraumatic rupture of the spleen associated with hemophagocytic syndrome and isolated splenic peliosis. Case reportAPMISYear: 200511355555710.1111/j.1600-0463.2005.apm_165.x16086827
Celebrezze JPJ,Cottrell DJ,William GB,Spontaneous splenic rupture due to isolated splenic peliosisSout Med JYear: 19989176376410.1097/00007611-199808000-00014
Parsons MA,Platts M,Slater D,Fox M,Splenic peliosis associated with rupture in a renal transplant patientPostgrad Med JYear: 19805666179679710.1136/pgmj.56.661.7967022418
Tsokos M,Puschel J,Isolated peliosis of the spleen: report of 2 autopsy casesAm J Forensic Med PatholYear: 20042525125410.1097/01.paf.0000127401.89952.6515322469
Lashbrook D,James R,Phillips A,Holbrook A,Agombar A,Splenic peliosis with spontaneous splenic rupture: report of two casesBMC SurgYear: 200661910.1186/1471-2482-6-916800889
Kohr RM,Haendiges M,Taube RR,Peliosis of the spleen: a rare cause of spontaneous splenic rupture with surgical implicationsAm SurgYear: 1993591971998476160
Hakoda S,Shinya H,Kiuchi S,Spontaneous splenic rupture caused by splenic peliosis of a hemodialysis patient with chronic renal failure receiving erythropoietinAm J Emerg MedYear: 2008261109 e1-109.e2. 18082796
Dennehy T,Lamphier TA,Wickman W,Goldberg R,Traumatic rupture of the normal spleen: Analysis of eighty-three casesAm J SurgYear: 19611021586510.1016/0002-9610(61)90686-913721887
Moore PG,Gillies JG,James OF,Saltos N,Occult ruptured spleen–two unusual clinical presentationsPostgrad Med JYear: 19846070017117310.1136/pgmj.60.700.1716709557
Lloyd TV,Johnson JC,Intramural gastric hematoma secondary to splenic ruptureSouth Med JYear: 1980731675167610.1097/00007611-198012000-000486969444
Mujtaba G,Josmi J,Arya M,Anand S,Spontaneous splenic rupture: A rare complication of acute pancreatitis in a patient with Crohn's diseaseCase Rep GastroenterolYear: 2011517918210.1159/00032721521552441
Ahmed A,Feller ER,Rupture of the spleen as the initial manifestation of Wilson's diseaseAm J GastroenterolYear: 199691145414558678016
Holt S,Spontaneous rupture of a normal spleen diagnosed as ruptured ectopic pregnancy. Two case reportsBr J Obstet GynaecolYear: 198289121062106310.1111/j.1471-0528.1982.tb04667.x7171518
Lam CM,Yuen ST,Yuen WK,Hemoperitoneum caused by spontaneous rupture of a true splenic cystHepatogastroenterologyYear: 199845188418869840169
Bhagrath R,Bearn P,Sanusi FA,Najjar S,Qureshi R,Simanovitz A,Postpartum rupture of the spleenBr J Obstet GynaecolYear: 199310095495510.1111/j.1471-0528.1993.tb15117.x8217982
Paravastu SC,Burdge A,da Silva A,Spontaneous splenic rupture in the postpartum periodBr J Hosp MedYear: 2008692106107
Kianmanesh R,Aguirre HI,Enjaume F,Valverde A,Brugière O,Vacher B,Bleichner G,Ruptures non traumatiques de la rate: trois nouveaux cas et revue de la littérature. Spontaneous splenic rupture: report of three new cases and review of the literatureAnn ChirYear: 2003128530330910.1016/S0003-3944(03)00092-012878066
Foley WJ,Thompson NW,Herlocher JE,Campbell DA,Occult rupture of the spleenSurg Gynecol ObstetYear: 19691286121512205781846
Mahesh B,Muwanga CL,Splenic infarct: a rare cause of spontaneous rupture leading to massive haemoperitoneumANZ J SurgYear: 2004741030103210.1111/j.1445-1433.2004.03227.x15550109
Gascón A,Iglesias E,Bélvis JJ,Berisa F,The elderly haemodialysis patient with abdominal symptoms and hypovolemic shock splenic rupture secondary to splenic infarction in a patient with severe atherosclerosisNephrol Dial TransplantYear: 1999141044104510.1093/ndt/14.4.104410328514
Kanagasundaram NS,Macdougall IC,Turney JH,Massive haemoperitoneum due to rupture of splenic infarct during CAPDNephrol Dial TransplantYear: 19981392380238110.1093/ndt/13.9.23809761530
Morgenstern L,McCafferty I,Rosenberg J,Michel SL,Hamartomas of the spleenArch SurgYear: 19841191291129310.1001/archsurg.1984.013902300570136497634
Yoshizawa J,Mizuno R,Yoshida T,Kanai M,Kurobe M,Yamazaki Y,Spontaneous rupture of splenic hamartoma: A case reportJ Pediatr SurgYear: 199934349849910.1016/S0022-3468(99)90512-210211667
Seyama Y,Tanaka N,Suzuki Y,Nagai M,Furuya T,Nomura Y,et al. Spontaneous rupture of splenic hamartoma in a patient with hepatitis C virus-related cirrhosis and portal hypertension: A case report and review of the literatureWorld J GastroenterolYear: 200612132133213516610071
Ballardini P,Incasa E,Del Noce A,Cavazzini L,Martoni A,Piana E,Spontaneous splenic rupture after the start of lung cancer chemotherapy. A case reportTumoriYear: 20049014414615143989
Foiada M,Muller W,Conti Rossini B,Pedrinis E,[Case report of spontaneous splenic rupture in splenoma]Helv Chir ActaYear: 1993601871908226053
Kesava-Rao RC G,Sawhney S,Berry M,Hemangioma of spleen with spontaneous, extra-peritoneal rupture, with associated splenic tuberculosis — an unusual presentationAustralas RadiolYear: 199337110010110.1111/j.1440-1673.1993.tb00025.x8323494
Norris PM,Hughes SCA,Strachan CJL,Spontaneous Rupture of a Benign Cavernous Haemangioma of the Spleen Following ThrombolysisEur J Vasc Endovasc SurgYear: 200325547647710.1053/ejvs.2002.183912713790
Neumann J,Ambrosius C,Zirngibl H,Spontaneous splenic rupture with diffused angiomatosis of the spleenChirurgYear: 199970780080210448589
Patel VG,Eltayeb OM,Zakaria M,Fortson JK,Weaver WL,Spontaneous Subcapsular Splenic Hematoma: A Rare Complication of PancreatitisAm SurgYear: 200571121066106916447482
McMahon NG,Norwood SH,Silva JS,Pancreatic pseudocyst with splenic involvement: an uncommon complication of pancreatitisSouth Med JYear: 19888191091210.1097/00007611-198807000-000253393950
Drapanas T,Yates AJ,Brickman R,Wholey M,The Syndrome of Occult Rupture of the SpleenAMA Arch SurgYear: 196999329830610.1001/archsurg.1969.013401500060024240456
Williams N,Gerrand C,London NJ,Chapman C,Bell PR,Splenic rupture following splenic vein thrombosis in a man with protein S deficiencyPostgrad Med JYear: 19926880592892910.1136/pgmj.68.805.9281494517
Windham TC,Risin SA,Tamm EP,Spontaneous Rupture of a Nontraumatic Intrasplenic AneurysmN Engl J MedYear: 2000342261999200010.1056/NEJM20000629342261610877657
Mayo P,Spontaneous rupture of the spleen presenting as acute thoracic empyemaSouth Med JYear: 1984771061106210.1097/00007611-198408000-000406463686
Paulvannan S,Pye JK,Spontaneous rupture of a normal spleenInt J Clin PractYear: 200357324524612723734
Wisniewski B,Vadrot J,D’Hubert E,Drouhin F,Fischer D,Denis J,Labayle D,Rupture spontanée de rate secondaire à une maladie des embolies de cristaux de cholestérol: à propos d’un casGastroenterol Clin BiolYear: 20042810, Part 192292410.1016/S0399-8320(04)95162-715523235
Spearman J,Alwan MH,Atraumatic rupture of the spleen: a cautionary noteANZ J SurgYear: 200676541942116768708
Robb BW,Reed MF,Congenital diaghragmatic hernia presenting as splenic rupture in an adultAnn Thorac SurgYear: 200681e9e1010.1016/j.athoracsur.2005.11.02716488674
Lamerton AJ,Spontaneous rupture of the spleen in early pregnancyPostgrad Med JYear: 19835969559659710.1136/pgmj.59.695.5966634563
Weekes LR,Ruptured spleen as a differential diagnosis in ruptured tubal pregnancyJ Natl Med AssocYear: 1984763453496737489
Buchsbaum HJ,Splenic rupture in pregnancy: report of a case and review of the literatureObstet Gynecol SurvYear: 19672238139510.1097/00006254-196706000-000014859770
Barnett T,Rupture of the spleen in pregnancy: a review of recorded cases with a further case reportJ Obstet Gynaecol Br EmpYear: 19525979580210.1111/j.1471-0528.1952.tb14762.x13000538
Gilbert CRA,Goldzieher JW,Cook TA,Insidious rupture of the spleen or splenic vessels associated with pregnancyJ Abdom SurgYear: 19646485714159862
Hunter RM,Shoemaker WC,Rupture of the spleen in pregnancy: a review of the subject and a case reportAm J Obstet GynecolYear: 1957731326133213424599
Nanda S,Gulati N,Sangwan K,Spontaneous splenic rupture in early pregnancyInt J Gynaecol ObstetYear: 1990311711731968866
O'Brien SE,Spontaneous rupture of the spleen in pregnancyCan Med Assoc JYear: 1963891366766814077814
Cobellis L,Stradella L,Pecori E,Cobellis G,Spontaneous rupture of the spleen in pregnancyMinerva GinecolYear: 20035528929014581877
Brocas E,Tenaillon A,Spontaneous splenic rupture in the second quarter of pregnancyAnn Fr Anesth ReanimYear: 20022123123410.1016/S0750-7658(02)00601-911963389
Landa Aranzabal MA,Tubia Landaberea JI,Esteban Aldezabal L,Carbajal Cervino C,Berdejo Lambarri L,Rotura espontanea de bazo. Presentacion de un caso registrado en una gestanteCir EspYear: 199149459460
Fletcher H,Frederick J,Barned H,Lizarraga V,Spontaneous rupture of the spleen in pregnancy with splenic conservationWest Indian Med JYear: 1989381141152763532
de Graaff J,Pijpers PM,Spontaneous rupture of the spleen in third trimester of pregnancyEur J Obstet Gynecol Reprod BiolYear: 19872524324710.1016/0028-2243(87)90105-53301450
Kiran G,Himsweta S,Spontaneous splenic rupture in pregnancy - a rare entityJ Obstet Gynecol IndiaYear: 200757545546
Thakkar U,Spontaneous rupture of spleenMed J ZambiaYear: 198115232347052886
Bljajić D,Ivanisević M,Djelmis J,Majerović M,Starcević V,Splenic rupture in pregnancy - traumatic or spontaneous event?Eur J Obstet Gynecol Reprod BiolYear: 200411511311410.1016/j.ejogrb.2003.10.02815223180
Popli K,Chitra R,Puri M,Spontaneous rupture of spleen in term pregnancyTrop DoctYear: 200434545514959986
Epstein M,King R,Kenney D,Splenic rupture at term. Case reportMo MedYear: 19838083846835196
Londero F,Cociancich G,Spontaneous rupture of the spleen in laborAm J Obstet GynecolYear: 200018378278310.1067/mob.2000.10655710992224
Touré B,Ouattara T,Ouédraogo A,Ouédraogo CMR,Koné B,[Splenic rupture during delivery. A case reportJournal Européen des UrgencesYear: 2004178789
Denehy T,McGrath EW,Breen JL,Splenic torsion and rupture in pregnancyObstet Gynecol SurvYear: 19884331231313285257
Sparkman RS,Rupture of the spleen in pregnancyAm J Obst and GynecolYear: 19587658759813571320
Huber DE,Martin SD,Orlay G,A case report of splenic pregnancyAust N Z J SurgeryYear: 198454818210.1111/j.1445-2197.1984.tb06692.x
Michaud P,Robillot P,Tescher M,Spontaneous rupture of the spleen in relation to a splenic pregnancy. Apropos of a caseRev Fr Gynecol ObstetYear: 1988832812823393799
Kalof AN,Fuller B,Harmon M,Splenic pregnancy. A case report and review of the literatureArch Pathol Lab MedYear: 2004128e146e14815504077
Caruso V,Hall WH,Primary abdominal pregnancy in the spleen: a case reportPathologyYear: 198416939410.3109/003130284090679186538959
Reddy KSP,Modgill VK,Intraperitoneal bleeding due to primary splenic pregnancyBr J SurgYear: 19837056410.1002/bjs.18007009206616165
Larkin JK,Garcia DM,Paulson EL,Powers DW,Primary splenic pregnancy with intraperitoneal bleeding and shock: a case reportIowa MedYear: 1988785295303229947
Yackel DB,Panton ON,Martin DJ,Lee D,Splenic pregnancy - a case reportObstet GynecolYear: 1988714714733347437
Kahn JA,Skjeldestad FE,Düring V,Sunde A,Molne K,Jørgensen OG,A spleen pregnancyActa Obstet Gynecol ScandYear: 198968838410.3109/000163489090876962801033
Cormio G,Santamato S,Vimercati A,Selvaggi L,Primary splenic pregnancy. A case reportJ Reprod MedYear: 20034847948112856525
Sakhel K,Aswad N,Usta I,Nassar A,Postpartum splenic ruptureObstet GynecolYear: 20031021207121010.1016/S0029-7844(03)00676-814607059
McCormick GM,Young DB,Spontaneous rupture of the spleen. A fatal complication of pregnancyAm J Forensic Med PatholYear: 19951613213410.1097/00000433-199506000-000107572867
Kaluarachchi A,Krishnamurthy S,Post-cesarean section splenic ruptureAm J Obstet GynecolYear: 199517323023210.1016/0002-9378(95)90199-X7631690
Huang YH,Hsu CY,Chang YF,Chen CP,Postcesarean splenic torsionTaiwan J Obstet GynecolYear: 20064525725910.1016/S1028-4559(09)60237-017175476
Barrilleaux PS,Adair D,Johnson G,Lewis DF,Splenic rupture associated with severe preeclampsiaA case report. J Reprod MedicineYear: 199944899901
Manda P,Dorman E,Olagbaiye F,Akinfenwa O,A case report of spontaneous splenic capsular rupture associated with atypical presentation of haemolysis, elevated liver enzymes, low platelet count (HELLP) syndromeJ Obstet GynaecolYear: 200424331731810.1080/0144361041000166100215203642
Maier A,Bataille F,Krenz D,Anthuber M,Angiosarcoma as a rare differential diagnosis in spontaneous rupture of the spleenDer ChirurgYear: 200475707410.1007/s00104-003-0733-4
Miyata T,Fujimoto Y,Fukushima M,Torisu M,Tanaka M,Spontaneous rupture of splenic angiosarcoma: A case report of chemotherapeutic approach and review of the literatureSurg TodayYear: 19932337037410.1007/BF003090588318793
Aranha GV,Gold J,Grage TB,Hemangiosarcoma of the spleen: report of a case and review of previously reported casesJ Surg OncolYear: 1976848148710.1002/jso.29300806071033439
Reale A,Petrogalli F,Hemangiosarcome of the spleenReport of a case. PathologicaYear: 19968814951
Simanski DA,Schiby G,Dreznik Z,Jacob ET,Rapid progressive dissemination of hemangiosarcoma of the spleen following spontaneous ruptureWorld J SurgYear: 198610114214510.1007/BF016561093962326
Sivelli R,Piccolo D,Soliani P,Franzini C,Ziegler S,Sianesi M,Rupture of the spleen in angiosarcoma: a case report and review of the literatureChir ItalYear: 20055737738016231829
Wick MR,Scheithauer BW,Smith SL,Beart RWJ,Primary nonlymphoreticular malignant neoplasms of the spleenAm J Surg PatholYear: 1982622924210.1097/00000478-198204000-000056285748
Winde G,Sprakel B,Bosse A,Reers B,Wendt M,Rupture of the spleen caused by primary angiosarcomaCase report. Acta Chir Eur J SurgYear: 19911573215217
Villedieu Poignant S,Mermet L,Bousquet A,Dupont P,Une cause rare d'hémopéritoine spontanéLa Revue de Médecine InterneYear: 2000219809811
Safarpor D,Safapor F,Aghajanzade M,Kohsari M,Hoda S,Spontaneous rupture of the spleen: A case report and review of the literatureSaudi J GastroenterolYear: 200713313613710.4103/1319-3767.3346619858631
Falk S,Krishnan J,Meis JM,Primary angiosarcoma of the spleen. A clinicopathologic study of 40 casesAm J Surg PatholYear: 19931795997010.1097/00000478-199310000-000018372948
Hsu JT,Chen HM,Lin CY,Yeh CN,Hwang TL,Jan YY,et al. Primary angiosarcoma of the spleenJ Surg OncolYear: 20059231231610.1002/jso.2041916299797
Neuhauser TS,Derringer GA,Thompson LD,Fanburg-Smith JC,Miettinen M,Saaristo A,et al. Splenic angiosarcoma: a clinicopathologic and immunophenotypic study of 28 casesMod PatholYear: 20001397898710.1038/modpathol.388017811007038
Mahony B,Jeffrey RB,Federle MP,Spontaneous rupture of the hepatic and splenic angiosarcoma demonstrated by CTAm J RoentgenolYear: 19831389659666979189
Thompson WM,Levy AD,Aguilera NS,Gorospe L,Abbott RM,Angiosarcoma of the Spleen: Imaging Characteristics in 12 PatientsRadiologyYear: 2005235110611510.1148/radiol.235104030815749977
Catalano O,Sandomenico F,Raso MM,Siani A,Real-time, contrast-enhanced sonography: A new tool for detecting active bleedingJ TraumaYear: 20055993393910.1097/01.ta.0000188129.91271.ab16374284
Kristoffersson A,Emdin S,Jarhult J,Acute intestinal obstruction and splenic hemmorrhage due to metastatic choriocarcinomaA case report. Acta ChirYear: 1985454381384
Ghinescu C,Sallami Z,Jackson D,Choriocarcinoma of the spleen - a rare cause of atraumatic ruptureAnn R Coll Surg EnglYear: 200890W12W1418430329
Hou HC,Chen CJ,Chang TC,Hsieh TT,Metastatic choriocarcinoma with spontaneous splenic rupture following term pregnancy: a case reportChanggeng Yi Xue Za ZhiYear: 1996191661708828260
Lam KY,Tang V,Metastatic Tumors to the SpleenArch Pathol Lab MedYear: 2000124452653010747308
Challis DE,Rew KJ,Steigrad SJ,Choriocarcinoma complicated by splenic rupture: an unusual presentationJ Obstet Gynaecol ResYear: 1996223954008870426
Giannakopoulos G,Nair S,Snider PS,Amenta C,Implications for the pathogenesis of aneurysm formation: Metastatic choriocarcinoma with spontaneous splenic rupture. Case report and a reviewSurg NeurolYear: 199238323624010.1016/0090-3019(92)90175-M1440209
Smith WM,Lucas JG,Frankel WL,Splenic rupture: A rare presentation of pancreatic carcinomaArch Pathol Lab MedYear: 2004128101146115015387707
Chung S,Park K,Li AK,A pancreatic tumour presenting as a ruptured spleenHPB SurgYear: 1989116116310.1155/1989/827832487063
Patrinou V,Skroubis G,Zolota V,Vagianos C,Unusual presentation of pancreatic mucinous cystadenocarcinoma by spontaneous splenic ruptureDig SurgYear: 20001764564710.1159/00005197911155016
Yettimis E,Trompetas V,Varsamidakis N,Courcoutsakis N,Polymeropoulos V,Kalokairinos E,Pathologic splenic ruptureAn unusual presentation of pancreatic cancer. PancreasYear: 200327273274
Otero-Palleiro MM,Barbagelata-Lopez C,Spontaneous rupture of the spleen: a rare form of onset gastric carcinoma]Med Clin (Barc)Year: 200612731816949025
Gupta PB,Harvey L,Spontaneous rupture of the spleen secondary to metastatic carcinomaBr J SurgYear: 19938061310.1002/bjs.18008005228518902
Lachachi F,Abita T,Durand Fontanier S,Maisonnette F,Descottes B,Spontaneous splenic rupture due to splenic metastasis of lung cancerAnn ChirYear: 200412952152210.1016/j.anchir.2004.09.00115556583
Kyriacou A,Arulraj N,Varia H,Acute abdomen due to spontaneous splenic rupture as the first presentation of lung malignancy: a case reportJ Med Case ReportsYear: 2011544410.1186/1752-1947-5-444
Tresallet C,Thibault F,Cardot V,Baleston F,Nguyen-Thanh Q,Chigot JP,et al. Spontaneous splenci rupture during intrasplenic Kaposi's sarcoma in an HIV-positive patientsGastroenterol Clin BiolYear: 2005291296129710.1016/S0399-8320(05)82227-416518293
Charters JW,Prince G,McGarry JM,Granulosa cell tumour presenting with haemoperitoneum and splenic ruptureCase report. Br J Obstet GynaecolYear: 198996735736
Hassan KS,Cohen HI,Hassan FK,Hassan SK,Unusual case of pancreatic inflammatory myofibroblastic tumor associated with spontaneous splenic ruptureWorld J Emerg SurgYear: 2010512810.1186/1749-7922-5-2821092210
Burg MD,Dallara JJ,Rupture of a previously normal spleen in association with enoxaparin: An unusual cause of shockJ Emerg MedYear: 200120434935210.1016/S0736-4679(01)00310-911348813
Weiss SJ,Smith T,Laurin E,Wisner DH,Spontaneous splenic rupture due to subcutaneous heparin therapyJ Emerg MedYear: 200018442142610.1016/S0736-4679(00)00157-810802418
Blankenship JC,Indeck M,Spontaneous splenic rupture complicating anticoagulant or thrombolytic therapyAm J MedYear: 199394443343710.1016/0002-9343(93)90156-J8475938
Kapan M,Kapan S,Karabicak I,Bavunoglu I,Simultaneous rupture of the liver and spleen in a patient on warfarin therapy: report of a caseSurg TodayYear: 20053525225510.1007/s00595-004-2898-y15772800
Ghobrial MW,Karim M,Mannam S,Spontaneous splenic rupture following the administration of intravenous heparin: case report and retrospective case reviewAm J HematolYear: 20027131431710.1002/ajh.1021412447963
Abad C,Fernández-Bethencourt M,Ortiz E,Rodríguez San Román JL,Facal P,Avila R,Spontaneous rupture of the spleen in a patient hypercoagulated with dicumarolRev Esp Enferm DigYear: 1992813663671377481
Badaoui R,Chebboubi K,Delmas J,Jakobina S,Mahjoub Y,Riboulot M,Rupture de la rate et anticoagulantAnn Fr Anesth ReanimYear: 200423774875010.1016/j.annfar.2004.04.01815324967
Gernigon Y,Beaumont E,Griffe J,Rupture spontanée de la rate chez un malade traité par les anticoagulantsArch Med OuestYear: 198012163167
Jabbour M,Tohmé C,Ingea H,Farah P,Spontaneous splenic rupture due to heparin. Report of a case and review of the literatureJ Med LibanYear: 1995431071098965304
Reches A,Almog R,Pauzner D,Almog B,Levin I,Spontaneous splenic rupture in pregnancy after heparin treatmentBJOGYear: 200511283783810.1111/j.1471-0528.2005.00531.x15924548
Kim H,Lee G,Park DJ,Lee JD,Chang S,Spontaneous splenic rupture in a hemodialysis patientYonsei Med JYear: 200546343543810.3349/ymj.2005.46.3.43515988818
Jayamaha AS,Patel JK,Orlikowski C,Splenic rupture following streptokinase therapyIntensive Care MedYear: 19942024410.1007/BF017047138014298
Gardner-Medwin J,Sayer J,Mahida YR,Spiller RC,SPONTANEOUS RUPTURE OF SPLEEN FOLLOWING STREPTOKINASE THERAPYLancetYear: 1989334867613982574340
Wiener RS,Ong LS,Streptokinase and splenic ruptureAm J MedYear: 1989832492913791
Lambert GW,Cook PS,Gardiner GA Jr,Regan JR,Spontaneous splenic rupture associated with thrombolytic therapy and/or concomitant heparin anticoagulationCardiovasc Intervent RadiolYear: 19921517717910.1007/BF027355831628284
Cheung PK,Arnold JM,McLarty TD,Splenic hemorrhage: a complication of tissue plasminogen activator treatmentCan J CardiolYear: 199061831852116935
Watring NJ,Wagner TW,Stark JJ,Spontaneous splenic rupture secondary to pegfilgrastim to prevent neutropenia in a patient with non–small-cell lung carcinomaAm J Emerg MedYear: 200725224724810.1016/j.ajem.2006.10.00517276841
Arshad M,Seiter K,Bilaniuk J,Qureshi A,Patil A,Ramaswamy G,et al. Side effects related to cancer treatment: Case 2Splenic rupture following pefgilgrastim. J Clin OncolYear: 20052385338534
Falzetti F,Aversa F,Minelli O,Tabilio A,Spontaneous rupture of spleen during peripheral blood stem-cell mobilisation in a healthy donorLancetYear: 1999353915255510028986
Dincer AP,Gottschall J,Margolis DA,Splenic rupture in a parental donor undergoing peripheral blood progenitor cell mobilizationJ Pediatr Hematol OncolYear: 20042676176310.1097/00043426-200411000-0001515543014
Pitini V,Ciccolo A,Arrigo C,Aloi G,Micali C,La Torre F,Spontaneous rupture of spleen during periferal blood stem cell mobilization in a patient with breast cancerHaematologicaYear: 200085555956010800183
Rossitto M,Versaci A,Barbera A,Broccio M,Lepore V,Ciccolo A,Spontaneous rupture of the spleen in a patient treated with chemotherapy and growth factors for stem cell mobilization]G ChirYear: 1998192042069677770
de Lezo Suarez j,Torres A,Herrera I,Pan M,Romero M,Pavlovic D,et al. Effects of stem-cell mobilization with recombinant human granulocyte colony stimulating factor in patients with percutaneously revascularized acute anterior myocardial infarctionRev Esp CardiolYear: 20055825326110.1157/1307247215766447
Balaguer H,Galmes A,Ventayol G,Bargay J,Besalduch J,Splenic rupture after granulocyte-colony-stimulating factor mobilization in a peripheral blood progenitor cell donorTransfusionYear: 2004441260126110.1111/j.1537-2995.2004.00413.x15265137
Becker PS,Wagle M,Matous S,Swanson RS,Pihan G,Lowry PA,et al. Spontaneous splenic rupture following administration of granulocyte colony-stimulating factor (G-CSF): occurrence in an allogeneic donor of peripheral blood stem cellsBiol Blood Marrow TransplantYear: 1997345499209740
Stuart D,Wolfer R,Spontaneous splenic rupture following administration of granulocyte colony-stimulating factor (G-CSF): a rare but fatal complicationJ Surg ResYear: 2007137306307
Loizon P,Nahon P,Founti H,Delecourt P,Rodor F,Jouglard J,Spontaneous rupture of the spleen under ticlopidine. Apropos of two casesJ Chir (Paris)Year: 19941313713747844197
Mitchell C,Riley CA,Vahid B,Unusual Complication of Heparin-Induced Thrombocytopenia After Mitral Valve Surgery: Spontaneous Rupture of SpleenAnn Thorac SurgYear: 20078331172117410.1016/j.athoracsur.2006.08.04717307485
Buciuto R,Kald A,Borch K,Spontaneous rupture of the spleenEur J SurgYear: 199215821291301350216
Morrin FJ,Guiney E,Spontaneous rupture of the normal spleenIr J Med SciYear: 19603611500505
Rice JP,Sutter CM,Spontaneous splenic rupture in an active duty Marine upon return from Iraq: a case reportJ Med Case ReportsYear: 2010435310.1186/1752-1947-4-353
Arnold RE,Van Vooren A,Spontaneous rupture of the spleen with hematomaSouth Med JYear: 197568786386410.1097/00007611-197507000-000131154074
Grech A,Spontaneous rupture of spleenBr Med JYear: 1971157401115539167
Lennard TW,Burgess P,Vomiting and "spontaneous" rupture of the spleenBr J Clin PractYear: 1985394074104074631
Toubia NT,Tawk MM,Potts RM,Kinasewitz GT,Cough and spontaneous rupture of a normal spleenChestYear: 200512831884188610.1378/chest.128.3.188416162801
Wehbe E,Raffi S,Osborne D,Spontaneous splenic rupture precipitated by cough: a case report and a review of the literatureScand J GastroenterolYear: 200843563463710.1080/0036552070176347218415760
Wergowske GL,Carmody TJ,Splenic Rupture From CoughingArch SurgYear: 1983118101227-a6615207
Kara E,Kaya Y,Zeybek R,Coskun T,Yavuz C,A case of diaphragmatic rupture complicated with laceration of stomach and spleen caused by a violent cough presenting with mediastinal shiftAnn Acad Med SingaporeYear: 200433649650
Thomas WEG,Apparent spontaneous rupture of the spleenBr Med JYear: 197816110409410624033
Lorimer WS Jr,Occult Rupture of the SpleenAMA Arch SurgYear: 196489343444010.1001/archsurg.1964.0132003002400414167393
Vas W,Friend WD,Rupture of a normal spleen caused by vomiting following a metrizamide myelogramDiagn ImagingYear: 19815063093127327071
Lemon M,Dorsch M,Street K,Cohen R,Hale P,Splenic rupture after vomitingJRSMYear: 20019410527528
Badenoch DF,Maurice HD,Gilmore OJ,Spontaneous rupture of a normal spleenJ R Coll Surg EdinbYear: 19853053263274078788
Baker AM,Adair NE,Acute hypercapnia and hemodynamic collapse in a 54-year-old manChestYear: 199510826626810.1378/chest.108.1.2667606968
Behera A,Aggarwal S,Kaman L,Spontaneous rupture of normal spleenIndian J GastroenterolYear: 199716271729114582
Bird D,Kelly MJ,Baird RN,Spontaneous rupture of the normal spleen: Diagnosis by computerized tomographyBr J SurgYear: 197966859810.1002/bjs.1800660825486925
Brodman HR,Bautista J,Spontaneous rupture of the normal spleen: review of the literature and report of one caseAMA Arch SurgYear: 195978340640910.1001/archsurg.1959.0432003005000913626347
Ceulemans B,Les ruptures spléniques pathologiquesLouvain MedYear: 2002121125132
Choudhury AK,Spontaneous rupture of a normal spleenInjuryYear: 200435332532610.1016/S0020-1383(03)00238-915124804
Coote JM,Eyers PS,Walker A,Wells IP,Intra-abdominal bleeding caused by spontaneous rupture of an accessory spleen: the CT findingsClin RadiolYear: 19995468969110.1016/S0009-9260(99)91093-010541397
Delaney PV,Spontaneous rupture of a normal spleenJ Ir Med AssocYear: 19726582115024783
Gallerani M,Vanini A,Salmi R,Bertusi M,Spontaneous rupture of the spleenAm J Emerg MedYear: 19961433333348639218
Gedik E,Girgin S,Aldemir M,Keles C,Tuncer MC,Aktas A,Non-traumatic splenic rupture: Report of seven cases and review of the literatureWorld J GastroenterolYear: 200814436711671610.3748/wjg.14.671119034976
Graham JW,Spontaneous rupture of the normal spleenMed J AustYear: 196047129529613828813
Gue S,Spontaneous rupture of the normal spleenCeylon Med JYear: 19782312325752424
Huang JF,Hsieh YH,Chen HY,Spontaneous spleen rupture diagnosed by abdominal sonography in a patient without underlying spleen pathologyUltrasound Med BiolYear: 2006325 supplementP224
Kiev J,Rothenberg B,Nance FC,Atraumatic splenic rupture in a healthy adultAm SurgYear: 1991577277291746783
Kumar S,Gupta A,Shrivastava UK,Mathur SB,Spontaneous rupture of normal spleen: an enigma recalledBr J Clin PractYear: 199246167681419560
Laseter T,McReynolds T,Spontaneous splenic ruptureMil MedYear: 2004169867367415379083
Mockford BJ,Brown RJ,An unusual case of delayed rupture of the spleen associated with pectus excavatumUlster Med JYear: 200271606112137168
Moran JC,Shah U,Singer JA,Spontaneous rupture of a wandering spleen: case report and literature reviewCurr SurgYear: 200360331031210.1016/S0149-7944(02)00737-714972263
Perl JI,Darter RW,Milles G,Spontaneous rupture of a normal spleen: report of a caseJ Int Coll SurgYear: 195830442042413588094
Stewart GR,Braasch JW,Spontaneous occult rupture of a normal spleenMed J AustYear: 1971142032055541613
Vahid B,Bosanac A,Marik P,Spontaneous rupture of the normal spleen: A case reportSurgery On-line 2005Year: 2010
Carles J,Guegan H,Crozat T,Janvier G,Riant T,Videau J,Spontaneous rupture of the spleen disclosing pheochromocytomaJ ChirYear: 1990127464467
Sowers N,Aubrey-Bassler FK,Trivial trauma and delayed rupture of a normal spleen: a case reportJ Med Case ReportsYear: 2011559110.1186/1752-1947-5-591
Douglas GJ,Simpson JS,The conservative management of splenic traumaJ Pediatr SurgYear: 19716556557010.1016/0022-3468(71)90380-05126276
Sjövall A,Hirsch K,Blunt abdominal trauma in children: Risks of nonoperative treatmentJ Pediatr SurgYear: 19973281169117410.1016/S0022-3468(97)90676-X9269964
Kluger Y,Paul DB,Raves JJ,Fonda M,Young JC,Townsend RN,Diamond D,Delayed rupture of the spleen-myths, facts, and their importance: case reports and literature reviewJ TraumaYear: 199436456857110.1097/00005373-199404000-000198158722
Allen TL,Greenlee RR,Price RR,Delayed splenic rupture presenting as unstable angina pectoris: case report and review of the literatureJ Emerg MedYear: 200223216516910.1016/S0736-4679(02)00486-912359285
Petitjean ME,Riant T,Tentiller E,Simonnet G,Janvier G,Erny P,Spontaneous splenic rupture disclosing a pheochromocytomaCan J AnaesthYear: 19923949549810.1007/BF030087151596975
Fried K,Kaufman S,Congenital afibrinogenemia in 10 offspring of uncle-niece marriagesClin GenetYear: 1980172232277363509
Vaiberg D,Sidlovsky S,Chris SM,Spontaneous rupture of spleen: report of a caseCan J SurgYear: 196589614252142
Nicoll JAV,Splenic haematoma after spontaneous rupture of the spleenAm J SurgYear: 196811611711810.1016/0002-9610(68)90431-55652345
Crate ID,Payne MJ,Is the diagnosis of spontaneous rupture of a normal spleen valid?J R Army Med CorpsYear: 1991137150512023171
Husni EA,Turell D,Spontaneous Rupture of the Normal Spleen: Does It Occur Without Trauma or Antecedent Disease?AMA Arch SurgYear: 196183228629010.1001/archsurg.1961.01300140128024
Tataria M,Dicker RA,Melcher M,Spain DA,Brundage SI,Spontaneous splenic rupture: the masquerade of minor traumaJ Trauma-Injury Infection & Critical CareYear: 200559512281230
Fleisher GR, Marx JA, Walls RM, Grayzel J, Wiley JFPediatric and Adult Emergency Medicine): UpToDate: Version 18Year: 2011UpToDate, Waltham, MA www.uptodate.com.

Figures

[Figure ID: F1]
Figure 1 

PRISMA [7] flow diagram documenting number of references processed. Legend: *Only abstracts containing all necessary information were included. Abbreviations: Assoc = associated.



[Figure ID: F2]
Figure 2 

Categorization of all splenic rupture cases meeting inclusion criteria. Legend: * Non-haematologic only; haematologic neoplasms are contained in the haematologic category.



Tables
[TableWrap ID: T1] Table 1 

Cases of splenic rupture following a medical procedure


Procedure <48 hours References >48 hours References
Colonoscopy
79
[8-20]
8
[10,11,21-23]
ERCP
4
[24-27]
4
[28-31]
Liver surgery
5
[32-36]
 
 
Pulmonary Surgery
2
[37,38]
 
 
Gastroscopy
 
 
1
[39]
Displaced CAPD catheter
 
 
1
[40]
ESWL
1
[41]
 
 
ECT
1
[42]
 
 
Abdominal surgery
1
[43]
 
 
Laparoscopy
1
[44]
 
 
Hysterectomy
4
[45-48]
 
 
TOTAL 98   14  

[TableWrap ID: T2] Table 2 

Cases of splenic rupture associated with previously undiagnosed infiltrative or inflammatory pathology


Disease Cases References
Infectious
 
 
 
Malaria
65
[49-60]
 
Mononucleosis
42
[61-90]
 
CMV
6
[91-95]
 
Typhoid fever
4
[96,97]
 
Endocarditis with splenic embolism
3
[98-100]
 
Pneumonia
3
[101-103]
 
HIV
3
[104-106]
 
Q fever
2
[107,108]
 
Salmonella sp.
2
[109,110]
 
Splenic tuberculosis
2
[111,112]
 
Viral Hepatitis
2
[113,114]
 
EBV
1
[115]
 
Babesiosis
1
[116]
 
Brucellosis
1
[117]
 
Bartonella
1
[118]
 
Dengue fever
1
[119]
 
Enterobacter cloacae
1
[120]
 
Murine typhus
1
[121]
 
Rickettsia sp.
1
[122]
 
Varicella
1
[123]
Haematologic
 
Non-Hodgkin’s Lymphoma
25
[124-145]
 
Hodgkin’s Lymphoma
5
[146-150]
 
Undifferentiated Lymphoma
3
[151-153]
 
Acute Lymphoblastic Leukemia
18
[154-165]
 
Chronic Myelogenous Leukemia
7
[166-172]
 
Acute Myelogenous Leukemia
6
[64,173-177]
 
Hairy Cell Leukemia
5
[178-182]
 
Acute T-cell Leukemia
1
[183]
 
Undfifferentiated Leukemia
1
[184]
 
Histiocytosis
6
[185-190]
 
Multiple Myeloma
2
[63,191]
 
Idiopathic Thrombocytic Purpura
1
[192]
 
Myelofibrosis
1
[193]
 
Polycythemia Vera
1
[194]
 
Sickle Cell Disease
1
[195]
 
Essential Thrombocythemia
1
[196]
Rheumatologic
 
 
 
Wegener’s Granulomatosis
3
[197-199]
 
Polyarteritis Nodosa
3
[200,201]
 
Systemic Lupus Erythematosis
3
[202-204]
 
Rheumatoid Arthritis
1
[205]
Other
 
 
 
Amyloidosis
24
[65,206-216]
 
Peliosis
8
[217-224]
 
Pancreatitis
5
[151,225-228]
 
Gaucher’s Disease
1
[80]
 
Wilson’s Disease
1
[229]
Total 276  

[TableWrap ID: T3] Table 3 

Cases of splenic rupture associated with the first diagnosis of a splenic or adjacent physical abnormality


Diseases Cases References
Splenic cyst
6
[6,61,230-233]
Splenic infarction
6
[234-238]
Splenic hamartoma
5
[239-243]
Hemangioma
3
[244-246]
Pancreatic pseudocyst
2
[247,248]
Thrombosed splenic vein
2
[249,250]
Splenic artery aneurysm
1
[251]
Empyema
1
[252]
Remote Pancreato-Renal Transplant
1
[253]
Cholesterol Embolism
1
[254]
Splenic granuloma
1
[255]
Congenital Diaphragmatic Hernia
1
[256]
Rib exostosis
1
[257]
TOTAL 31  

[TableWrap ID: T4] Table 4 

Pregnancy related causes of splenic rupture


Cause Cases References
Normal pregnancy
22
[257-278]
Splenic ectopic pregnancy
9
[279-287]
Post-vaginal delivery
2
[288,289]
Post-caesarean section
2
[290,291]
Preeclampsia
1
[292]
Ruptured ectopic pregnancy
1
[225]
Non-splenic
 
 
HELLP syndrome
1
[293]
Total 38  

Abbreviations: HELLP: Hemolysis, Elevated Liver Enzymes, Low Platelets.


[TableWrap ID: T5] Table 5 

Previously undiagnosed, non-hematologic neoplastic causes of spontaneous splenic rupture


Cause Cases References
Angiosarcoma
31
[294-309]
Choriocarcinoma
5
[310-315]
Pancreatic cancer
4
[316-319]
Gastric cancer
1
[320]
Lung cancer
4
[313,321-323]
Kaposi Sarcoma
1
[324]
Granulosa cell tumour
1
[325]
Myofibroblastic tumour
1
[326]
Total 48  

[TableWrap ID: T6] Table 6 

Other cases of splenic rupture


Cause Cases References
Medication related
 
 
 
Anticoagulant
21
[327-337]
 
Thrombolytic
13
[83,329,338-342]
 
Recombinant G-CSF
10
[343-352]
 
Anti-platelet agents
2
[353]
 
HIT
1
[354]
Internal trauma-related
 
 
 
Cough
12
[98,151,355-364]
 
Vomiting
4
[365-368]
 
Seizure
1
[249]
Miscellaneous
 
 
 
Spontaneous
35
[43,61,63-65,80,113,225,249,369-391]
 
>48h after minor external trauma
6
[249,392-396]
 
Pheochromocytoma
2
[397,398]
 
Afibrinogenemia
1
[399]
TOTAL 108  

Abbreviations: G-CSF: Granulocyte Colony Stimulating Factor; HIT: Heparin Induced Thrombocytopenia.



Article Categories:
  • Research Article

Keywords: Splenic rupture, Rupture, Spontaneous, Atraumatic, Presenting complaint, Initial manifestation.

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