Document Detail

A 6-year clinical trial of methotrexate therapy in the treatment of ectopic pregnancy.
MedLine Citation:
PMID:  9720836     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our aim was to assess the efficiency of methotrexate therapy for unruptured ectopic pregnancy. STUDY DESIGN: From November 1990 to December 1996, 60 patients diagnosed with unruptured ectopic pregnancies were treated by the Departamento de Ginecología y Obstetricia at the Hospital Virgen Macarena of Seville. Of these, 14 patients received an intrasacular injection of 15 mg of methotrexate, 45 were given an intramuscular dose of 50 mg/m2 and only one received the drug by both routes. RESULTS: Forty-six patients (76.7%) responded successfully to treatment. Of these, 10 had been given the drug intrasacularly (10/15, 66.7%), while 36 had received the drug intramuscularly (36/46, 78.3%). Twenty patients (33.3%) had minor side effects, the most frequent being mild abdominal pain. Falling levels of leukocytes on the third day after initiation of treatment may serve as a fairly accurate criterion to predict the patient's response to the treatment. CONCLUSION: Our data support the use of methotrexate therapy as a reliable alternative to surgical intervention in the treatment of unruptured ectopic pregnancy. Intramuscular administration, without laparoscopy, appears to be the most convenient route as it is easily implemented and has comparatively few complications.
A Jiménez-Caraballo; G Rodríguez-Donoso
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  79     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-10-29     Completed Date:  1998-10-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  IM    
Departamento de Ginecología y Obstetricia, Hospital Universitario Virgen Macarena, Seville, Spain.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / therapeutic use*
Chorionic Gonadotropin, beta Subunit, Human / blood
Methotrexate / administration & dosage,  adverse effects,  therapeutic use*
Pregnancy, Ectopic / drug therapy*
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Chorionic Gonadotropin, beta Subunit, Human; 59-05-2/Methotrexate
Comment In:
Eur J Obstet Gynecol Reprod Biol. 1999 Feb;82(2):233   [PMID:  10206424 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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