| A 6-month randomized pilot study of black tea and cardiovascular risk factors. | |
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MedLine Citation:
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PMID: 17892999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The effects of black tea consumption on cardiovascular risk factors have been inconsistent in previous randomized trials, all of which have been limited to a few weeks duration. METHODS: We conducted a pilot parallel-design randomized controlled trial among 31 adults aged 55 years and older with either diabetes or 2 other cardiovascular risk factors but no established clinical cardiovascular disease. Participants were randomized to drink 3 glasses daily of either a standardized black tea preparation or water for 6 months. Cardiovascular risk factors were measured at the beginning and conclusion of the study. RESULTS: Three participants dropped out of the study, leaving 14 participants assigned to tea and 14 assigned to water eligible for analyses. We found no statistically significant effects of black tea on cardiovascular biomarkers, including lipids, inflammatory markers, hemoglobin, adhesion molecules, prothrombotic and fibrinolytic parameters, and lipoprotein oxidizability. Assignment to tea did not appreciably influence blood pressure, and heart rate among participants assigned to tea was marginally higher than among control participants at 3 months (P = .07) but not 6 months. CONCLUSIONS: In this randomized trial of black tea intake over 6 months among older adults with known cardiovascular risk factors, black tea did not appreciably influence any traditional or novel biomarkers of cardiovascular risk. Longer randomized trials are needed to verify the inverse association of tea with risk of cardiovascular disease seen in cohort studies and identify potential candidate mechanisms for such an association. |
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Authors:
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Kenneth J Mukamal; Kristen MacDermott; Joe A Vinson; Noriko Oyama; Warren J Manning; Murray A Mittleman |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American heart journal Volume: 154 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-25 Completed Date: 2007-11-06 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 724.e1-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02446, USA. kmukamal@bidmc.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood Cardiovascular Diseases / blood*, epidemiology* Diabetes Mellitus / blood Female Humans Male Middle Aged Pilot Projects Risk Factors Tea* |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR001032-290863/RR/NCRR NIH HHS; M01 RR001032-30A10863/RR/NCRR NIH HHS; R21 AT001899-01A1/AT/NCCAM NIH HHS; R21 AT001899-02/AT/NCCAM NIH HHS; R21AT01899/AT/NCCAM NIH HHS; RR01032/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Tea |
| Comments/Corrections | |
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