| A 6-month, randomized, double-masked comparison of latanoprost with timolol in patients with open angle glaucoma or ocular hypertension. | |
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MedLine Citation:
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PMID: 8739678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intraocular pressure reducing effect and side-effects of latanoprost, a phenyl-substituted prostaglandin analogue, were compared with those of timolol, in a group of 31 glaucomatous or ocular hypertensive patients, divided into three subgroups. The study was randomized and double masked. At the end of 6 month's treatment with latanoprost 0.005% once daily, either as a morning dose or as an evening dose, there was a reduction in intraocular pressure of 33% (p < 0.001) and 36% (p < 0.001), respectively. The intraocular pressure reduction of timolol 0.5%, administered twice daily was 26% (p < 0.001). There was no significant difference in conjunctival hyperemia between the groups and there were few subjective symptoms in any of the patients. One patient with a light green-brown iris, treated with latanoprost in one eye only, exhibited an increase in iris colour in the treated eye at week 26, and did not show any signs of reversion 9 months after discontinuing the therapy. It may be concluded that latanoprost is well tolerated and at least as effective as timolol in reducing intraocular pressure in patients with glaucoma or ocular hypertension when applied once daily. The exact mechanism behind the increase in iris pigmentation and the clinical significance of this previously unknown side-effect needs to be investigated further. |
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Authors:
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B Friström |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta ophthalmologica Scandinavica Volume: 74 ISSN: 1395-3907 ISO Abbreviation: Acta Ophthalmol Scand Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-10-04 Completed Date: 1996-10-04 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 9507578 Medline TA: Acta Ophthalmol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 140-4 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Linköping, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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administration & dosage,
adverse effects,
therapeutic use* Adult Aged Aged, 80 and over Double-Blind Method Female Follow-Up Studies Glaucoma, Open-Angle / drug therapy*, physiopathology Humans Intraocular Pressure / drug effects Male Middle Aged Ocular Hypertension / drug therapy*, physiopathology Ophthalmic Solutions Prostaglandins F, Synthetic / administration & dosage, adverse effects, therapeutic use* Safety Scandinavia Timolol / administration & dosage, adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Ophthalmic Solutions; 0/Prostaglandins F, Synthetic; 130209-82-4/latanoprost; 26839-75-8/Timolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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