Document Detail


6-Thioguanine for Crohn's disease during pregnancy: thiopurine metabolite measurements in both mother and child.
MedLine Citation:
PMID:  16334449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
6-Thioguanine is used as an escape thiopurine for treating inflammatory bowel disease patients intolerant or refractory to azathioprine, 6-mercaptopurine or methotrexate. Case reports show conflicting data on the use of 6-thioguanine throughout pregnancy. The administration of the standard thiopurines is believed to be relatively safe. We describe two patients with Crohn's disease treated with low-dose 6-thioguanine during all trimesters of their pregnancies. The pregnancies resulted in two healthy infants: without congenital abnormalities, laboratory signs of myelosuppression or hepatocellular injury. Thiopurine metabolites were measured in mother and infant. Significantly lower levels of 6-thioguaninenucleotides were found in the erythrocytes of the infant compared to the mother (ratio 1:12). Further studies are needed to determine the clinical importance of thiopurine metabolite measurements during pregnancy in mother and child.
Authors:
Nanne K H de Boer; Ruurd M Van Elburg; Abraham J Wilhelm; Adriana J Remmink; John M G Van Vugt; Chris J J Mulder; Adriaan A Van Bodegraven
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  40     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-12-07     Completed Date:  2006-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1374-7     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology and Hepatology, PO Box 7057, VU University Medical Centre, 1007 MB Amsterdam, The Netherlands. KHN.deBoer@vumc.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Crohn Disease / diagnosis*,  drug therapy*
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Follow-Up Studies
Gestational Age
Humans
Maternal-Fetal Exchange / drug effects*
Pregnancy
Pregnancy Complications / diagnosis,  drug therapy*
Pregnancy Outcome*
Pregnancy, High-Risk
Risk Assessment
Severity of Illness Index
Thioguanine / administration & dosage*,  adverse effects
Chemical
Reg. No./Substance:
154-42-7/Thioguanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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