Document Detail


ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.
MedLine Citation:
PMID:  23392608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adaptation to nutrient scarcity depends on the activation of metabolic programs to efficiently use internal reserves of energy. Activation of these programs in abundant food regimens can extend life span. However, the common molecular and metabolic changes that promote adaptation to nutritional stress and extend life span are mostly unknown. Here we present a response to fasting, enrichment of ω-6 polyunsaturated fatty acids (PUFAs), which promotes starvation resistance and extends Caenorhabditis elegans life span. Upon fasting, C. elegans induces the expression of a lipase, which in turn leads to an enrichment of ω-6 PUFAs. Supplementing C. elegans culture media with these ω-6 PUFAs increases their resistance to starvation and extends their life span in conditions of food abundance. Supplementation of C. elegans or human epithelial cells with these ω-6 PUFAs activates autophagy, a cell recycling mechanism that promotes starvation survival and slows aging. Inactivation of C. elegans autophagy components reverses the increase in life span conferred by supplementing the C. elegans diet with these fasting-enriched ω-6 PUFAs. We propose that the salubrious effects of dietary supplementation with ω-3/6 PUFAs (fish oils) that have emerged from epidemiological studies in humans may be due to a similar activation of autophagic programs.
Authors:
Eyleen J O'Rourke; Petric Kuballa; Ramnik Xavier; Gary Ruvkun
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-02-07
Journal Detail:
Title:  Genes & development     Volume:  27     ISSN:  1549-5477     ISO Abbreviation:  Genes Dev.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-22     Completed Date:  2013-04-09     Revised Date:  2014-09-03    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autophagy / physiology*
Caenorhabditis elegans / metabolism,  physiology*
Caenorhabditis elegans Proteins / genetics,  metabolism
Cell Line
Fasting / physiology
Fatty Acids, Omega-6 / metabolism*
Gene Expression Regulation
HeLa Cells
Humans
Lipase / genetics,  metabolism
Lipolysis
Longevity / physiology*
Mice
Survival Analysis
Grant Support
ID/Acronym/Agency:
K99 DK087928/DK/NIDDK NIH HHS; K99DK087928/DK/NIDDK NIH HHS; P30 DK043351/DK/NIDDK NIH HHS; R01DK070147/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Fatty Acids, Omega-6; EC 3.1.1.3/LIPL-4 protein, C elegans; EC 3.1.1.3/Lipase
Comments/Corrections
Comment In:
Genes Dev. 2013 Feb 15;27(4):351-4   [PMID:  23431052 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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