Document Detail

ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.
MedLine Citation:
PMID:  23392608     Owner:  NLM     Status:  MEDLINE    
Adaptation to nutrient scarcity depends on the activation of metabolic programs to efficiently use internal reserves of energy. Activation of these programs in abundant food regimens can extend life span. However, the common molecular and metabolic changes that promote adaptation to nutritional stress and extend life span are mostly unknown. Here we present a response to fasting, enrichment of ω-6 polyunsaturated fatty acids (PUFAs), which promotes starvation resistance and extends Caenorhabditis elegans life span. Upon fasting, C. elegans induces the expression of a lipase, which in turn leads to an enrichment of ω-6 PUFAs. Supplementing C. elegans culture media with these ω-6 PUFAs increases their resistance to starvation and extends their life span in conditions of food abundance. Supplementation of C. elegans or human epithelial cells with these ω-6 PUFAs activates autophagy, a cell recycling mechanism that promotes starvation survival and slows aging. Inactivation of C. elegans autophagy components reverses the increase in life span conferred by supplementing the C. elegans diet with these fasting-enriched ω-6 PUFAs. We propose that the salubrious effects of dietary supplementation with ω-3/6 PUFAs (fish oils) that have emerged from epidemiological studies in humans may be due to a similar activation of autophagic programs.
Eyleen J O'Rourke; Petric Kuballa; Ramnik Xavier; Gary Ruvkun
Related Documents :
7741208 - Mechanisms in adverse reactions to food. the ear.
24854238 - Comparing farmers' market revenue trends before and after the implementation of a monet...
20448908 - Microwave-assisted maillard reactions for the preparation of advanced glycation end pro...
7167418 - The selectivity of the anorectic effect of satietin. i. the ineffectiveness of satietin...
21896298 - Parent use of food to soothe infant/toddler distress and child weight status. an explor...
12163918 - Street foods in accra, ghana: how safe are they?
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-02-07
Journal Detail:
Title:  Genes & development     Volume:  27     ISSN:  1549-5477     ISO Abbreviation:  Genes Dev.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-22     Completed Date:  2013-04-09     Revised Date:  2014-09-03    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-40     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Autophagy / physiology*
Caenorhabditis elegans / metabolism,  physiology*
Caenorhabditis elegans Proteins / genetics,  metabolism
Cell Line
Fasting / physiology
Fatty Acids, Omega-6 / metabolism*
Gene Expression Regulation
HeLa Cells
Lipase / genetics,  metabolism
Longevity / physiology*
Survival Analysis
Grant Support
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Fatty Acids, Omega-6; EC protein, C elegans; EC
Comment In:
Genes Dev. 2013 Feb 15;27(4):351-4   [PMID:  23431052 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Downregulation of Serotonergic Gene Expression in the Raphe Nuclei of the Midbrain Under Chronic Soc...
Next Document:  Multiple roles for Piwi in silencing Drosophila transposons.