Document Detail

6-Hydroxydopamine lesions of the ventral tegmentum abolish D-amphetamine and morphine analgesia in the formalin test but not in the tail flick test.
MedLine Citation:
PMID:  2118819     Owner:  NLM     Status:  MEDLINE    
The effect of bilateral 6-hydroxdopamine (with desipramine) lesions of the ventral tegmental area-substantia nigra region on analgesia produced by morphine and D-amphetamine was examined with the formalin and tail flick tests in rats. These lesions depleted dopamine, but not noradrenaline, in the ventral and anterior striatum. Morphine and D-amphetamine produced analgesia in the formalin test in sham lesioned rats but not in lesioned rats. In contrast, morphine produced the same degree of analgesia in the tail flick test in sham lesioned and lesioned rats while D-amphetamine did not produce analgesia in this test. These data suggest that morphine and D-amphetamine analgesia in the formalin test involves dopamine, whereas morphine analgesia in the tail flick test does not.
M J Morgan; K B Franklin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  519     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-10-16     Completed Date:  1990-10-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  144-9     Citation Subset:  IM    
Department of Psychology, McGill University, Montreal, Que., Canada.
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MeSH Terms
Corpus Striatum / physiology*
Dextroamphetamine / pharmacology*
Dopamine / physiology
Morphine / pharmacology*
Pain / physiopathology*
Substantia Nigra / physiology*
Reg. No./Substance:
0/Hydroxydopamines; 1199-18-4/Oxidopamine; 50-00-0/Formaldehyde; 51-64-9/Dextroamphetamine; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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