Document Detail

6-Hydroxydopamine lesions of the ventral tegmental area suppress ghrelin's ability to elicit food-reinforced behavior.
MedLine Citation:
PMID:  21640160     Owner:  NLM     Status:  MEDLINE    
While past research suggests that ghrelin stimulates appetite through an action on hypothalamic signaling, recent evidence indicates that the peptide acts via mesotelencephalic dopamine neurons to alter appetitive motivation. In the present study, rats were trained to operantly respond for food on a progressive ratio PR5 schedule until stable breakpoints were established. Ghrelin (30-300 pmol) was then injected directly into the ventral tegmental area (VTA) and the 300 pmol dose was observed to increase breakpoint. The dopaminergic neurotoxin 6-hydroxydopamine (6-OHDA, 6 μg) was subsequently administered into the VTA resulting in a significant depletion of striatal dopamine. Stable breakpoints were then re-established. When ghrelin's effects were reassessed, the peptide's ability to alter operant responding for food was reliably reduced. Our findings demonstrate that ghrelin induces food-reinforced behavior in the mesotelencephalic reward pathway and that this effect is dependent on intact dopaminergic signaling. We conclude that the metabolic peptide ghrelin interacts with dopamine, within reward circuitry, to modulate appetitive behavior.
Zachary Y Weinberg; Marjorie L Nicholson; Paul J Currie
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-23
Journal Detail:
Title:  Neuroscience letters     Volume:  499     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-27     Completed Date:  2012-05-14     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  70-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Conditioning, Operant / drug effects,  physiology
Dopamine / physiology
Eating / drug effects,  physiology*
Ghrelin / administration & dosage*,  antagonists & inhibitors
Injections, Intraventricular
Neural Pathways / drug effects,  physiology
Oxidopamine / toxicity*
Rats, Sprague-Dawley
Reinforcement Schedule*
Ventral Tegmental Area / drug effects,  physiology*
Reg. No./Substance:
0/Ghrelin; 8HW4YBZ748/Oxidopamine; VTD58H1Z2X/Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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