| The 5'VNTR proinsulin gene (INS) polymorphism and the functional reserve of β cells in the intravenous glucose tolerance test. | |
| | |
MedLine Citation:
|
PMID: 21507316 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Introduction: Proinsulin 5'VNTR polymorphism determines susceptibility to type 1 diabetes (T1DM). The authors tested whether it affects intravenous glucose tolerance test (IVGTT) results. Aim of the study: To evaluate a possible relationship between 5'VNTR proinsulin gene (INS) polymorphism and glucose, insulin and C-peptide levels during IVGTT among siblings of childen suffering from T1DM. Material and methods: Fourteen patients - siblings of children with type 1 diabetes, positive for at least one autoantibody, underwent IVGTT with glucose, insulin and C-peptide concentrations measurement. Results: Mean age of patients equaled 10.71±4.15 years. Eight individuals were homozygous for class I/I and six were class III/I heterozygotes. No significant differences in blood glucose levels during the IVGTT were observed (p=0.67). However, lower insulin (p=0.03) and C-peptide (p=0.01) levels were observed in I/I homozygotes in post-challenge timepoints. No significant differences were observed in baseline fasting insulin, glucose and C-peptide levels. Conclusions: The class III allele in the 5'VNTR promoter region of INS is associated with a greater functional reserve of β cells in response to a direct hyperglycemic stimulus in individuals with a familial background of T1DM. |
| | |
Authors:
|
Wojciech Fendler; Krystyna Wyka; Agnieszka Cieślik-Heinrich; Ewa Polakowska; Justyna Jastrzębska; Wojciech Młynarski |
Related Documents
:
|
22416896 - Does self monitoring of blood glucose as opposed to urinalysis provide additional benef... 7629286 - Comparative analysis of human papillomavirus detection by pcr and non-isotopic in situ ... 3044806 - Complement-mediated cytotoxic effects of islet cell surface antibodies in non-diabetic ... 2488686 - Lack of interaction of hla and igg heavy chain allotypes in insulin-dependent diabetes ... 12145346 - Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for i... 21525796 - Glucose meter accuracy and the impact on the care of diabetes in childhood and adolesce... |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: Pediatric endocrinology, diabetes, and metabolism Volume: 17 ISSN: 2081-237X ISO Abbreviation: - Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-4-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101518750 Medline TA: Pediatr Endocrinol Diabetes Metab Country: - |
Other Details:
|
Languages: ENG Pagination: 5-9 Citation Subset: - |
Vernacular Title:
|
Polimorfizm 5'VNTR genu proinsuliny (INS) a rezerwa czynnościowa komórek β trzustki podczas dożylnej próby obciążenia glukozą |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Signal transduction pathway mediated by thrombopoietin in the inflammation model of microglia.
Next Document: Coincidence of Poland's syndrome with Turner's syndrome.