| 5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents. | |
| | |
MedLine Citation:
|
PMID: 19303291 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Various functionalized mono- and diarylanthranilo-1,3-dinitriles were synthesized and evaluated for their in vitro antihyperglycemic activity against the PTP-1B, glucose-6-phosphatase, glycogen phosphorylase and alpha-glucosidase enzymes. Among various screened compounds, 5,6-diaryl substituted anthranilo-1,3-dinitriles 3a, 3b, and 3d showed good inhibitory activity against PTP-1B with IC(50) values of 58-72 microM. Three of the test compounds showed significant (25-37%) lowering of plasma glucose level at 24h in sucrose-challenged streptozotocin-induced diabetic Sprague-Dawley rat model. |
| | |
Authors:
|
Fateh V Singh; Amrita Parihar; Sumit Chaurasia; Amar B Singh; Salil P Singh; Akhilesh K Tamrakar; Arvind K Srivastava; Atul Goel |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-04 |
Journal Detail:
|
Title: Bioorganic & medicinal chemistry letters Volume: 19 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-04-03 Completed Date: 2009-08-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
|
Languages: eng Pagination: 2158-61 Citation Subset: IM |
Affiliation:
|
Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Diabetes Mellitus, Experimental / blood, drug therapy Hypoglycemic Agents / chemical synthesis*, classification*, therapeutic use Male Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
|
0/Hypoglycemic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for...
Next Document: Efficient synthesis of oligonucleotide conjugates on solid-support using an (aminoethoxycarbonyl)ami...