Document Detail


55th Bowditch Lecture: Effects of chronic hypoxia on the pulmonary circulation: role of HIF-1.
MedLine Citation:
PMID:  22923506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When exposed to chronic hypoxia (CH), the pulmonary circulation responds with enhanced contraction and vascular remodeling, resulting in elevated pulmonary arterial pressures. Our work has identified CH-induced alterations in the expression and activity of several ion channels and transporters in pulmonary vascular smooth muscle that contribute to the development of hypoxic pulmonary hypertension and uncovered a critical role for the transcription factor hypoxia-inducible factor-1 (HIF-1) in mediating these responses. Current work is focused on the regulation of HIF in the chronically hypoxic lung and evaluation of the potential for pharmacological inhibitors of HIF to prevent, reverse, or slow the progression of pulmonary hypertension.
Authors:
Larissa A Shimoda
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Publication Detail:
Type:  Lectures; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-23
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  113     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-05     Completed Date:  2013-04-12     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1343-52     Citation Subset:  IM    
Affiliation:
Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA. shimodal@welch.jhu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / complications,  drug therapy,  physiopathology*
Calcium / metabolism
Humans
Hydrogen-Ion Concentration
Hypertension, Pulmonary / etiology,  physiopathology,  prevention & control
Hypoxia-Inducible Factor 1 / antagonists & inhibitors,  physiology*
Lung / physiopathology
Muscle, Smooth, Vascular / physiopathology
Potassium Channels / metabolism
Pulmonary Artery / physiopathology
Pulmonary Circulation / physiology*
Chemical
Reg. No./Substance:
0/Hypoxia-Inducible Factor 1; 0/Potassium Channels; 7440-70-2/Calcium
Comments/Corrections

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