Document Detail


55Co-EDTA for renal imaging using positron emission tomography (PET): a feasibility study.
MedLine Citation:
PMID:  10755649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The feasibility of imaging renal function with 55Co-ethylene diamine tetraacetic acid (EDTA) and dynamic positron emission tomography was investigated. A group of normal Wistar rats was injected intravenously with 55Co-EDTA and underwent dynamic positron emission tomography (PET) imaging in order to study the biodistribution. The time-activity curves of the heart (blood pool), both kidneys, liver, and bladder were observed. In two animals, blood and urinary clearances of 55Co-EDTA were compared with those for 51Cr-EDTA. In one animal, unilateral reduction in kidney function was induced and the right/left ratio for the kidneys was determined. The time-activity curves showed that 55Co-EDTA cleared rapidly from the blood pool (heart), whereas prompt and high target-to-background ratios for both kidneys were obtained. The entire tracer was cleared from the renal parenchyma by urinary excretion and collection of the activity in the bladder. No specific activity uptake was noticed in any other organ or tissue. The clearances of 55Co-EDTA and 51Cr-EDTA in blood were not significantly different, showing that the nature of the M++ has no influence on the in vivo behavior of EDTA. 55Co can be produced easily by cyclotron irradiation and 55Co-EDTA is a promising physiological tracer for nephrological research using PET.
Authors:
P Goethals; A Volkaert; C Vandewielle; R Dierckx; N Lameire
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nuclear medicine and biology     Volume:  27     ISSN:  0969-8051     ISO Abbreviation:  Nucl. Med. Biol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-07-07     Completed Date:  2000-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9304420     Medline TA:  Nucl Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  77-81     Citation Subset:  IM    
Affiliation:
Institute for Nuclear Sciences, Gent, Flanders, Belgium. PatrickP.Goethals@rug.ac.be
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MeSH Terms
Descriptor/Qualifier:
Animals
Chelating Agents / chemical synthesis,  diagnostic use,  pharmacokinetics*
Chromium Radioisotopes / diagnostic use
Cobalt Radioisotopes / diagnostic use
Edetic Acid / chemical synthesis,  diagnostic use,  pharmacokinetics*
Feasibility Studies
Glomerular Filtration Rate
Injections, Intravenous
Kidney / drug effects,  metabolism*,  radionuclide imaging
Liver / metabolism
Male
Metabolic Clearance Rate
Myocardium / metabolism
Rats
Rats, Wistar
Tissue Distribution
Tomography, Emission-Computed
Urinary Bladder / metabolism
Chemical
Reg. No./Substance:
0/Chelating Agents; 0/Chromium Radioisotopes; 0/Cobalt Radioisotopes; 60-00-4/Edetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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