| The -514 C->T hepatic lipase promoter region polymorphism and plasma lipids: a meta-analysis. | |
| | |
MedLine Citation:
|
PMID: 15292318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Investigations of the -514 C-->T single nucleotide polymorphism (SNP) in the hepatic lipase (HL) gene promoter region (LIPC) have yielded contradictory results regarding its association with changes in plasma lipids. The current study is a meta-analysis of 25 publications on this SNP, comprising over 24,000 individuals, and its relationship with total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL), triglycerides, and HL activity. Significant decreases were observed in HL activity for both the CT and TT genotypes compared with the CC genotype [weighted mean difference (WMD), -5.83 mmol/liter.h (95% confidence interval, -8.48, -3.17) and -11.05 mmol/liter.h (95% confidence interval, -14.74, -7.36), respectively]. Moreover, significant increases in HDL were found; the CT to CC comparison showed an increase in WMD of 0.04 mmol/liter (95% confidence interval, 0.02, 0.05) mmol/liter, and the increase in the TT vs. CC difference was WMD of 0.09 mmol/liter (95% confidence interval, 0.07, 0.12). These changes appear to be stepwise, implying an allele dosage effect. All P values for these associations were less than 0.001. This meta-analysis demonstrates the importance of the -514C-->T SNP in determining HL activity and plasma HDL concentration and helps quantify the role that hepatic lipase plays in the metabolism of HDL. |
| | |
Authors:
|
Aaron Isaacs; Fakhredin A Sayed-Tabatabaei; Omer T Njajou; Jacqueline C M Witteman; Cornelia M van Duijn |
Related Documents
:
|
9660998 - Differences in the lipoprotein distribution of free and liposome-associated all-trans-r... 11507678 - Pre-heparin plasma lipoprotein lipase mass: correlation with intra-abdominal visceral f... 8735358 - The menopause and hormone replacement therapy: lipids, lipoproteins, coagulation and fi... 3675308 - Effect of gender, age, and lipid status on low density lipoprotein subfraction distribu... 19371448 - Evaluation of an ffq for assessment of antioxidant intake using plasma biomarkers in an... 3126738 - The glycopeptide moiety of vasopressin-neurophysin precursor is neurohypophysial prolac... |
Publication Detail:
|
Type: Journal Article; Meta-Analysis |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: 89 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2004 Aug |
Date Detail:
|
Created Date: 2004-08-04 Completed Date: 2004-09-03 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 3858-63 Citation Subset: AIM; IM |
Affiliation:
|
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cytosine Genotype Humans Lipase / genetics* Polymorphism, Single Nucleotide* Promoter Regions, Genetic / genetics* Thymine |
| Chemical | |
Reg. No./Substance:
|
65-71-4/Thymine; 71-30-7/Cytosine; EC 3.1.1.3/Lipase; EC 3.1.1.3/hepatic lipase, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intelligence quotient and iodine intake: a cross-sectional study in children.
Next Document: Intramuscular and liver triglycerides are increased in the elderly.