Document Detail


A 5-year retrospective study assessing the association between seasonal and meteorological change and incidence of aneurysmal subarachnoid haemorrhage.
MedLine Citation:
PMID:  20726749     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: Seasonal variation in incidence of spontaneous subarachnoid haemorrhage (SAH) is well recognised. This retrospective single-centre study aimed to characterise seasonality of SAH in the temperate climate of London, UK and to determine associations of incidence with meteorological variables. We further investigated whether associations vary according to location of aneurysm.
METHODS: Admission data on 647 patients admitted with spontaneous SAH from December 2003 to August 2008 was analysed using our neurosurgical referrals database. Average monthly incidence of SAH was correlated with local temperature, atmospheric pressure and humidity data. In a subset of 467 patients, impact of aneurysm location on seasonal variation was evaluated.
RESULTS: A non-significant bi-annual peak incidence was observed in Spring and Autumn with a trough in Summer (chi(2) = 1.5, p = 0.47). This trend was particularly marked with middle cerebral and posterior communicating artery aneurysms. However, anterior communicating artery aneurysmal SAH peaked in Summer only. SAH incidence correlated significantly with average humidity (coefficient 0.213, CI (0.02-0.404), p = 0.035) and peak humidity (coefficient 0.128, CI (0.008-0.248), p = 0.041). Temperature and atmospheric pressure did not correlate with incidence.
CONCLUSIONS: This study illustrates a pattern of variation in SAH incidence similar to that seen in other populations and climates. However, our data suggests that this pattern differs according to aneurysm location. Unusually, we also find that humidity, and not temperature or atmospheric pressure, correlates with SAH incidence. Seasonal variability in aneurysm rupture is likely to be multifactorial, but meteorological factors may play an important role.
Authors:
Mark A Hughes; Patrick J Grover; Colin R Butler; Vivian A Elwell; Nigel D Mendoza
Related Documents :
1282769 - Cerebrovascular effects of substance p after experimental subarachnoid haemorrhage.
14620199 - Unilateral oculomotor nerve paresis associated with anterior communicating artery aneur...
2808899 - Two cases of sudden death by rupture of traumatic and bacterial aneurysms.
1423039 - Mechanism of cerebral vasospasm following subarachnoid hemorrhage in monkeys.
11486119 - Vasospasm in monkeys resolves because of loss of and encasement of subarachnoid blood c...
10642769 - Diffuse alveolar hemorrhage following administration of tirofiban or abciximab: a nemes...
3715819 - Thrombin uptake and inhibition on heparinized polytetrafluoroethylene (ptfe) grafts and...
16684069 - Cardiac tamponade caused by acute spontaneous coronary artery rupture.
23645649 - Use of heparin in aortic dissection: beware the misdiagnosis of acute pulmonary embolism.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of neurosurgery     Volume:  24     ISSN:  1360-046X     ISO Abbreviation:  Br J Neurosurg     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800054     Medline TA:  Br J Neurosurg     Country:  England    
Other Details:
Languages:  eng     Pagination:  396-400     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Charing Cross Hospital, London, UK. hughes81@gmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Patient safety and image transfer between referring hospitals and neuroscience centres: could we do ...
Next Document:  Standard intracranial in vivo animal models of delayed cerebral vasospasm.