Document Detail

A 5-year prospective, observational study of the withdrawal of antihypertensive treatment in elderly people.
MedLine Citation:
PMID:  8207364     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To observe blood pressure, cardiovascular events, and total mortality after withdrawing antihypertensive treatment for elderly patients. DESIGN: Multicentre observational study. SETTING: Sweden. A 5-year follow-up of 333 elderly hypertensive patients, aged 70-84 years (mean age 75.2 +/- SD 3.8 years, 68% females). In all, 74 out of the 333 patients (22%) died during the study period. METHOD: After withdrawal of the antihypertensive therapy, all patients started in the untreated state and during the 5-year follow-up they could then either remain in the untreated state, or be reverted to blood-pressure-lowering drug treatment because of hypertension or other diseases, e.g. angina pectoris, oedema, congestive heart failure, etc. RESULTS: The probability of remaining without treatment for 5 years was estimated to be 20%. During the state of no treatment the patients had a lower total mortality risk than that of the general Swedish population, matched for age and sex. They also had a lower risk of cardiovascular events than those in the treated states. Markers indicating a successful withdrawal were monotherapy in low doses and relatively low blood pressure before withdrawal. CONCLUSION: These results suggest that with frequent check-ups, withdrawal of antihypertensive therapy in the elderly can be tried without increased risk of cardiovascular events.
T Ekbom; L H Lindholm; A Od?n; B Dahl?f; L Hansson; P O Wester; B Scherst?n
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of internal medicine     Volume:  235     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-12     Completed Date:  1994-07-12     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  581-8     Citation Subset:  IM    
Health Sciences Centre, Lund University, Dalby/Lund, Sweden.
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MeSH Terms
Aged, 80 and over
Antihypertensive Agents / therapeutic use*
Cardiovascular Diseases / epidemiology*,  mortality
Follow-Up Studies
Hypertension / drug therapy*
Prospective Studies
Risk Factors
Reg. No./Substance:
0/Antihypertensive Agents
Comment In:
J Intern Med. 1994 Jun;235(6):577-9   [PMID:  8207363 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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